Oral Gavage of Ginger Nanoparticle-Derived Lipid Vectors Carrying Dmt1 siRNA Blunts Iron Loading in Murine Hereditary Hemochromatosis

AIN-93 Purified Diets for Laboratory Rodents: Final Report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet

Reeves, P. G., Nielsen, F. H., & Fahey, G. C., Jr. (1993) · Journal of Nutrition · doi:10.1093/jn/123.11.1939 · Cited by 8,730 · see citing works

Iron bioavailability and dietary reference values

Hurrell, R., & Egli, I. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.28674f · Cited by 1,359 · see citing works

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

Fleming, M. D., Trenor, C. C., Su, M. A., Foernzler, D., Beier, D. R., Dietrich, W. F., & Andrews, N. C. (1997) · Nature Genetics · doi:10.1038/ng0897-383 · Cited by 1,159 · see citing works

Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer

Zhang, M., Viennois, É., Prasad, M. A., Zhang, Y., Wang, L., Zhang, Z., Han, M. K., Xiao, B., Xu, C., Srinivasan, S., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.018 · Cited by 1,037 · see citing works

<i>Nramp</i> <i>2</i> is mutated in the anemic Belgrade ( <i>b</i> ) rat: Evidence of a role for Nramp2 in endosomal iron transport

Fleming, M. D., Romano, M. A., Su, M. A., Garrick, L. M., Garrick, M. D., & Andrews, N. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1148 · Cited by 936 · see citing works

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

Roetto, A., Papanikolaou, G., Politou, M., Alberti, F., Girelli, D., Christakis, J., Loukopoulos, D., & Camaschella, C. (2003) · Nature Genetics · doi:10.1038/ng1053 · Cited by 860 · see citing works

Identification of an Intestinal Folate Transporter and the Molecular Basis for Hereditary Folate Malabsorption

Qiu, A., Jansen, M., Sakaris, A., Min, S. H., Chattopadhyay, S., Tsai, E., Sandoval, C., Zhao, R., Akabas, M. H., & Goldman, I. D. (2006) · Cell · doi:10.1016/j.cell.2006.09.041 · Cited by 847 · see citing works

Interspecies communication between plant and mouse gut host cells through edible plant derived exosome‐like nanoparticles

Mu, J., Zhuang, X., Wang, Q., Jiang, H., Deng, Z., Wang, B., Zhang, L., Kakar, S. S., Jun, Y., Miller, D. M., et al. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300729 · Cited by 731 · see citing works

An immunoradiometric assay for ferritin in the serum of normal subjects and patients with iron deficiency and iron overload

Addison, G. M., Beamish, M. R., Hales, C. N., Hodgkins, M., Jacobs, A. J., & Llewellin, P. (1972) · Journal of Clinical Pathology · doi:10.1136/jcp.25.4.326 · Cited by 595 · see citing works

Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells

Liuzzi, J. P., Aydemir, F., Nam, H., Knutson, M. D., & Cousins, R. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606424103 · Cited by 577 · see citing works

Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids

Wang, Q., Zhuang, X., Mu, J., Deng, Z., Jiang, H., Zhang, L., Xiang, X., Wang, B., Yan, J., Miller, D., et al. (2013) · Nature Communications · doi:10.1038/ncomms2886 · Cited by 528 · see citing works

HFE gene knockout produces mouse model of hereditary hemochromatosis

Zhou, X. Y., Tomatsu, S., Fleming, R. E., Parkkila, S., Waheed, A., Jiang, J., Fei, Y., Brunt, E. M., Ruddy, D. A., Prass, C. E., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2492 · Cited by 519 · see citing works

Biochemical Markers and Hematologic Indices in the Diagnosis of Functional Iron Deficiency

Thomas, C., & Thomas, L. (2002) · Clinical Chemistry · doi:10.1093/clinchem/48.7.1066 · Cited by 491 · see citing works

Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver

Gunshin, H., Fujiwara, Y., Custodio, A. O., DiRenzo, C., Robine, S., & Andrews, N. C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24356 · Cited by 419 · see citing works

A guide to Ussing chamber studies of mouse intestine

Clarke, L. L. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90649.2008 · Cited by 419 · see citing works

Nramp2 is mutated in the anemic Belgrade (b) rat : evidence of a role for Nramp2 in endosomal iron transport

Flemming (1998) · Medical Entomology and Zoology · Cited by 412 · see citing works

Mechanistic and regulatory aspects of intestinal iron absorption

Gulec, S., Anderson, G. J., & Collins, J. F. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00348.2013 · Cited by 406 · see citing works

The SLC39 family of metal ion transporters

Eide, D. J. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1074-3 · Cited by 405 · see citing works

ZIP8 Is an Iron and Zinc Transporter Whose Cell-surface Expression Is Up-regulated by Cellular Iron Loading

Wang, C., Jenkitkasemwong, S., Duarte, S., Sparkman, B. K., Shawki, A., Mackenzie, B., & Knutson, M. D. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.367284 · Cited by 381 · see citing works

Grapefruit-Derived Nanovectors Use an Activated Leukocyte Trafficking Pathway to Deliver Therapeutic Agents to Inflammatory Tumor Sites

Wang, Q., Ren, Y., Mu, J., Egilmez, N. K., Zhuang, X., Deng, Z., Zhang, L., Yan, J., Miller, D. M., & Zhang, H. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3095 · Cited by 371 · see citing works

Plant derived edible nanoparticles as a new therapeutic approach against diseases

Zhang, M., Viennois, E., Xu, C., & Merlin, D. (2016) · Tissue Barriers · doi:10.1080/21688370.2015.1134415 · Cited by 311 · see citing works

Oral Administration of ginger-derived Nanolipids Loaded With siRNA As a Novel Approach for Efficient siRNA Drug Delivery to Treat Ulcerative Colitis

Zhang, M., Wang, X., Han, M. K., Collins, J. F., & Merlin, D. (2017) · Nanomedicine · doi:10.2217/nnm-2017-0196 · Cited by 305 · see citing works

Iron-dependent regulation of the divalent metal ion transporter

Gunshin, H., Allerson, C. R., Polycarpou-Schwarz, M., Rofts, A., Rogers, J. T., Kishi, F., Hentze, M. W., Rouault, T. A., Andrews, N. C., & Hediger, M. A. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03189-1 · Cited by 305 · see citing works

Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: Increased duodenal expression of the iron transporter DMT1

Fleming, R. E., Migas, M. C., Zhou, X., Jiang, J., Britton, R. S., Brunt, E. M., Tomatsu, S., Waheed, A., Bacon, B. R., & Sly, W. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3143 · Cited by 269 · see citing works

Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis

Lesbordes-Brion, J.-C., Viatte, L., Bennoun, M., Lou, D.-Q., Ramey, G., Houbron, C., Hamard, G., Kahn, A., & Vaulont, S. (2006) · Blood · doi:10.1182/blood-2006-02-003376 · Cited by 257 · see citing works

Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis

Zhang, M., Xu, C., Liu, D., Han, M. K., Wang, L., & Merlin, D. (2017) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjx115 · Cited by 229 · see citing works

Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload

Mims, M. P., Guan, Y., Pospı́šilová, D., Priwitzerova, M., Indrák, K., Ponka, P., Divoký, V., & Prchal, J. T. (2005) · Blood · doi:10.1182/blood-2004-07-2966 · Cited by 219 · see citing works

Genes that modify the hemochromatosis phenotype in mice

Levy, J. E., Montross, L. K., & Andrews, N. C. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9635 · Cited by 212 · see citing works

Folic Acid Functionalized Nanoparticles for Enhanced Oral Drug Delivery

Roger, E., Kalscheuer, S., Kirtane, A. R., Guru, B. R., Grill, A. E., Whittum‐Hudson, J. A., & Panyam, J. (2012) · Molecular Pharmaceutics · doi:10.1021/mp2005388 · Cited by 178 · see citing works

Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease

Xiao, B., & Merlin, D. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.730517 · Cited by 156 · see citing works

Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese

Shawki, A., Anthony, S., Nose, Y., Engevik, M. A., Niespodzany, E. J., Barrientos, T., Öhrvik, H., Worrell, R. T., Thiele, D. J., & Mackenzie, B. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00160.2015 · Cited by 156 · see citing works

Erythropoietic regulators of iron metabolism

Ganz, T. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.07.003 · Cited by 153 · see citing works

Food iron absorption in idiopathic hemochromatosis

Lynch, S., SKIKNE, B. S., & Cook, J. (1989) · Blood · doi:10.1182/blood.v74.6.2187.bloodjournal7462187 · Cited by 148 · see citing works

Microcytic anemia and hepatic iron overload in a child with compound heterozygous mutations in DMT1 (SCL11A2)

Iolascon, A., D’Apolito, M., Servedio, V., Cimmino, F., Piga, A. G., & Camaschella, C. (2005) · Blood · doi:10.1182/blood-2005-06-2477 · Cited by 143 · see citing works

Cellular localization of divalent metal transporter DMT-1 in rat kidney

Ferguson, C. J., Wareing, M., Ward, D. T., Green, R., Smith, C. P., & Riccardi, D. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.280.5.f803 · Cited by 135 · see citing works

Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload

Beaumont, C. (2006) · Blood · doi:10.1182/blood-2005-10-4269 · Cited by 124 · see citing works

Diagnostic Test Equivalent Hemoglobin Reticulocyte in Iron Deficiency Anemia

Sanyoto, A., Suega, K., Adnyana, W. L., & Bakta, I. M. (2017) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v9i3.267 · Cited by 104 · see citing works

Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice

Canonne‐Hergaux, F., & Gros, P. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00405.x · Cited by 96 · see citing works

Comparison of mammalian cell lines expressing distinct isoforms of divalent metal transporter 1 in a tetracycline-regulated fashion

Garrick, M. D., Kuo, H.-C., Vargas, F. P., Singleton, S. T., Zhao, L., Smith, J. J., Paradkar, P. N., Roth, J. A., & Garrick, L. M. (2006) · Biochemical Journal · doi:10.1042/bj20051987 · Cited by 80 · see citing works

In vivo characterization of renal iron transport in the anaesthetized rat

Wareing, M., Ferguson, C. J., Green, R., Riccardi, D., & Smith, C. P. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00581.x · Cited by 79 · see citing works

Non-transferrin-bound iron uptake in Belgrade and normal rat erythroid cells

Garrick, L. M., Dolan, K. G., Romano, M. A., & Garrick, M. D. (1999) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199903)178:3 · Cited by 78 · see citing works

A THALASSEMIA‐LIKE DISORDER IN BELGRADE LABORATORY RATS*

Sladić-Simić, D., Martinovitch, P. N., Z̆ivković, N., PavicA, D., Martinović, J. V., Kahn, M., & Ranney, H. M. (1969) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1969.tb27779.x · Cited by 78 · see citing works

A novel N491S mutation in the human SLC11A2 gene impairs protein trafficking and in association with the G212V mutation leads to microcytic anemia and liver iron overload

Bardou‐Jacquet, E., Island, M., Jouanolle, A., Détivaud, L., Fatih, N., Ropert, M., Brissot, É., Mosser, A., Maisonneuve, H., Brissot, P., et al. (2011) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2011.07.004 · Cited by 61 · see citing works

Phenotypic analysis of hemochromatosis subtypes reveals variations in severity of iron overload and clinical disease

Sandhu, K., Flintoff, K., Chatfield, M. D., Dixon, J. L., Ramm, L. E., Ramm, G. A., Powell, L. W., Subramaniam, V. N., & Wallace, D. F. (2018) · Blood · doi:10.1182/blood-2018-02-830562 · Cited by 61 · see citing works

Iron absorption by heterozygous carriers of the HFE C282Y mutation associated with hemochromatosis

Hunt, J. R., & Zeng, H. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.4.924 · Cited by 58 · see citing works

High-Iron Consumption Impairs Growth and Causes Copper-Deficiency Anemia in Weanling Sprague-Dawley Rats

Ha, J., Doğuer, Ç., Wang, X., Flores, S. R., & Collins, J. F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161033 · Cited by 57 · see citing works

Characterization and genetic studies of microcytic anemia in house mouse.

RUSSELL, E. S., NASH, D. J., BERNSTEIN, S. E., KENT, E. L., MCFARLAND, E. C., MATTHEWS, S. M., & NORWOOD, M. S. (1970) · Blood · doi:10.1182/blood.v35.6.838.838 · Cited by 51 · see citing works

A novel R416C mutation in human DMT1 (SLC11A2) displays pleiotropic effects on function and causes microcytic anemia and hepatic iron overload

Lam-Yuk-Tseung, S., Camaschella, C., Iolascon, A., & Gros, P. (2006) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2006.01.011 · Cited by 50 · see citing works

Functional consequences of the human DMT1 (SLC11A2) mutation on protein expression and iron uptake

Priwitzerova, M., Nie, G., Sheftel, A. D., Pospı́šilová, D., Divoký, V., & Ponka, P. (2005) · Blood · doi:10.1182/blood-2005-04-1550 · Cited by 46 · see citing works

Investigation of Iron Metabolism in Mice Expressing a Mutant Menke’s Copper Transporting ATPase (Atp7a) Protein with Diminished Activity (Brindled; MoBr/y)

Güleç, Ş., & Collins, J. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066010 · Cited by 42 · see citing works

Relevance of dietary iron intake and bioavailability in the management of HFE hemochromatosis: a systematic review

Moretti, D., van Doorn, G. M., Swinkels, D. W., & Melse‐Boonstra, A. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.048264 · Cited by 40 · see citing works

Do Ginger-Derived Nanoparticles Represent an Attractive Treatment Strategy for Inflammatory Bowel Diseases?

Zhang, M., Collins, J. F., & Merlin, D. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0353 · Cited by 37 · see citing works

Silencing the Menkes Copper-Transporting ATPase (Atp7a) Gene in Rat Intestinal Epithelial (IEC-6) Cells Increases Iron Flux via Transcriptional Induction of Ferroportin 1 (Fpn1)

Güleç, Ş., & Collins, J. F. (2013) · Journal of Nutrition · doi:10.3945/jn.113.183160 · Cited by 35 · see citing works

Functional characterization of the E399D DMT1/NRAMP2/SLC11A2 protein produced by an exon 12 mutation in a patient with microcytic anemia and iron overload

Lam-Yuk-Tseung, S., Mathieu, M., & Gros, P. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.05.008 · Cited by 33 · see citing works

An Amino Acid Mixture Mitigates Radiation-induced Gastrointestinal Toxicity

Yin, L., Vijaygopal, P., Menon, R., Vaught, L. A., Zhang, M., Zhang, L., Okunieff, P. G., & Vidyasagar, S. (2014) · Health Physics · doi:10.1097/hp.0000000000000117 · Cited by 31 · see citing works

Regulation of Body Iron Content Through Excretion in the Mouse

Chappelle, E. H., Gabrio, B. W., STEVENS, A. R., & Finch, C. A. (1955) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1955.182.2.390 · Cited by 26 · see citing works

Impaired renal function and development in Belgrade rats

Veuthey, T., Hoffmann, D., Vaidya, V. S., & Wessling‐Resnick, M. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00285.2013 · Cited by 23 · see citing works

Progressive Increases in Dietary Iron Are Associated with the Emergence of Pathologic Disturbances of Copper Homeostasis in Growing Rats

Ha, J., Doğuer, Ç., Flores, S. R., Wang, T., & Collins, J. F. (2018) · Journal of Nutrition · doi:10.1093/jn/nxx070 · Cited by 23 · see citing works

Acute inflammation alters bicarbonate transport in mouse ileum

Zhang, H., Ameen, N. A., Melvin, J. E., & Vidyasagar, S. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.129262 · Cited by 20 · see citing works

Intestinal absorption of iron in HFE-1 hemochromatosis: local or systemic process?

Brissot, P., Troadec, M., & Loréal, O. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.01.020 · Cited by 15 · see citing works

Modeling the dynamics of mouse iron body distribution: hepcidin is necessary but not sufficient

Parmar, J. H., Davis, G., Shevchuk, H., & Mendes, P. (2017) · BMC Systems Biology · doi:10.1186/s12918-017-0431-3 · Cited by 12 · see citing works

Radiation decreases murine small intestinal HCO 3 − secretion

Zhang, K., Yin, L., Zhang, M., Parker, M. D., Binder, H. J., Salzman, P., Zhang, L., Okunieff, P. G., & Vidyasagar, S. (2011) · International Journal of Radiation Biology · doi:10.3109/09553002.2011.583314 · Cited by 10 · see citing works

Iron metabolism and iron disorders revisited in the hepcidin era

Camaschella, C., Nai, A., & Silvestri, L. (2020) · Haematologica · doi:10.3324/haematol.2019.232124 · Cited by 734 · see citing works

Plant-derived exosome-like nanoparticles and their therapeutic activities

Kim, J., Li, S., Zhang, S., & Wang, J. (2021) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2021.05.006 · Cited by 412 · see citing works

Extracellular Vesicles—Connecting Kingdoms

Woith, E., Fuhrmann, G., & Melzig, M. F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225695 · Cited by 331 · see citing works

Technology insight: Plant-derived vesicles—How far from the clinical biotherapeutics and therapeutic drug carriers?

Cong, M., Tan, S., Li, S., Gao, L., Huang, L., Zhang, H.-G., & Qiao, H. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114108 · Cited by 311 · see citing works

Characterization of the MicroRNA Profile of Ginger Exosome-like Nanoparticles and Their Anti-Inflammatory Effects in Intestinal Caco-2 Cells

Yin, L., Yan, L., Yu, Q., Wang, J., Liu, C., Wang, L., & Zheng, L. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c07306 · Cited by 209 · see citing works

Plant Extracellular Vesicles and Nanovesicles: Focus on Secondary Metabolites, Proteins and Lipids with Perspectives on Their Potential and Sources

Woith, E., Guerriero, G., Hausman, J.-F., Renaut, J., Leclercq, C. C., Weise, C., Legay, S., Weng, A., & Melzig, M. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073719 · Cited by 201 · see citing works

A cost-effective polyethylene glycol-based method for the isolation of functional edible nanoparticles from ginger rhizomes

Kalarikkal, S. P., Prasad, D., Kasiappan, R., Chaudhari, S. R., & Sundaram, G. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-61358-8 · Cited by 185 · see citing works

Plant-Derived Extracellular Vesicles and Their Exciting Potential as the Future of Next-Generation Drug Delivery

Alzahrani, F. A., Khan, M. I., Kameli, N., Alsahafi, E., & Riza, Y. M. (2023) · Biomolecules · doi:10.3390/biom13050839 · Cited by 143 · see citing works

Bioactive compounds and biological functions of medicinal plant-derived extracellular vesicles

Hao, S., Yang, H., Hu, J., Luo, L., Yuan, Y., & Liu, L. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107062 · Cited by 110 · see citing works

Focusing on Future Applications and Current Challenges of Plant Derived Extracellular Vesicles

Wang, Y., Wang, J., Ma, J., Zhou, Y., & Lu, R. (2022) · Pharmaceuticals · doi:10.3390/ph15060708 · Cited by 98 · see citing works

Engineering Strategies of Plant-Derived Exosome-Like Nanovesicles: Current Knowledge and Future Perspectives

Li, Y., Wang, Y., Zhao, H., Pan, Q., & Chen, G. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s496664 · Cited by 97 · see citing works

Low pH-Based Method to Increase the Yield of Plant-Derived Nanoparticles from Fresh Ginger Rhizomes

Suresh, A. P., Kalarikkal, S. P., Pullareddy, B., & Sundaram, G. M. (2021) · ACS Omega · doi:10.1021/acsomega.1c02162 · Cited by 94 · see citing works

Nanovesicles from Organic Agriculture-Derived Fruits and Vegetables: Characterization and Functional Antioxidant Content

Logozzi, M., Raimo, R. D., Mizzoni, D., & Fais, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158170 · Cited by 79 · see citing works

Development of nanoparticles derived from corn as mass producible bionanoparticles with anticancer activity

Sasaki, D., Kusamori, K., Takayama, Y., Itakura, S., Todo, H., & Nishikawa, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-02241-y · Cited by 79 · see citing works

Application of plant-derived exosome-like nanoparticles in drug delivery

Barzin, M., Bagheri, A. M., Ohadi, M., Abhaji, A. M., Salarpour, S., & Dehghannoudeh, G. (2023) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2023.2202242 · Cited by 83 · see citing works

Edible pueraria lobata-derived exosome-like nanovesicles ameliorate dextran sulfate sodium-induced colitis associated lung inflammation through modulating macrophage polarization

Lu, Y., Xu, J., Tang, R., Zeng, P., Li, Z., You, J., Li, T., Zhang, T., Ma, X., He, Y., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116098 · Cited by 63 · see citing works

Iron, Copper, and Zinc Homeostasis: Physiology, Physiopathology, and Nanomediated Applications

Szabó, R., Bodolea, C., & Mocan, T. (2021) · Nanomaterials · doi:10.3390/nano11112958 · Cited by 59 · see citing works

Plant-derived nanovesicles: Promising therapeutics and drug delivery nanoplatforms for brain disorders

Wang, R., Zhang, Y., Guo, Y., Zeng, W., Li, J., Wu, J. J., Li, N., Zhu, A., Li, J., Di, L., et al. (2023) · Fundamental Research · doi:10.1016/j.fmre.2023.09.007 · Cited by 59 · see citing works

DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration

Ingrassia, R., Garavaglia, B., & Memo, M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00575 · Cited by 60 · see citing works

Cell‐type‐specific insights into iron regulatory processes

Mleczko‐Sanecka, K., & Silvestri, L. (2020) · American Journal of Hematology · doi:10.1002/ajh.26001 · Cited by 59 · see citing works

Ligand-modified nanocarriers for oral drug delivery: Challenges, rational design, and applications

Zhang, Y., Wang, Y., Li, X., Nie, D., Liu, C., & Gan, Y. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.11.010 · Cited by 50 · see citing works

Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment

Yi, C., Lu, L., Li, Z., Guo, Q., Ou, L., Wang, R., & Tian, X. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01621-x · Cited by 52 · see citing works

RNAi therapies: Expanding applications for extrahepatic diseases and overcoming delivery challenges

Lee, J. W., Shim, M. K., Kim, H., Jang, H., Lee, Y., & Kim, S. H. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.115073 · Cited by 46 · see citing works

Plant-derived exosomes in therapeutic nanomedicine, paving the path toward precision medicine

Zheng, M., Chavda, V. P., Vaghela, D. A., Bezbaruah, R., Gogoi, N. R., Patel, K., Kulkarni, M., Shen, B., & Singla, R. K. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156087 · Cited by 46 · see citing works

Unlocking the Medicinal Potential of Plant-Derived Extracellular Vesicles: current Progress and Future Perspectives

Liu, X., Lou, K., Zhang, Y. ‐. P., Li, C., Wei, S., & Feng, S. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s463145 · Cited by 46 · see citing works

Plant-derived nanovesicles as an emerging platform for cancer therapy

Liu, H., Luo, G., & Shang, Z. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.08.033 · Cited by 43 · see citing works

Innovative Strategies to Combat 5-Fluorouracil Resistance in Colorectal Cancer: The Role of Phytochemicals and Extracellular Vesicles

Barathan, M., Zulpa, A. K., Ng, S. L., Lokanathan, Y., Ng, M. H., & Law, J. X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137470 · Cited by 43 · see citing works

Chinese herbal medicine-derived extracellular vesicles as novel biotherapeutic tools: present and future

Zhang, J., Tian, S., Guo, L., Zhao, H., Mao, Z., & Miao, M. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05892-3 · Cited by 42 · see citing works

Therapeutic potential and pharmacological significance of extracellular vesicles derived from traditional medicinal plants

Wu, P., Wu, W., Zhang, S., Han, J., Liu, C., Han, Y., Chen, X., & Chen, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1272241 · Cited by 41 · see citing works

Plant Derived Exosome-Like Nanoparticles and Their Therapeutic Applications in Glucolipid Metabolism Diseases

Liu, R., Zhang, F., He, X., & Huang, K. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c12480 · Cited by 41 · see citing works

Advancing glioblastoma treatment through iron metabolism: A focus on TfR1 and Ferroptosis innovations

Caverzán, M. D., & Ibarra, L. E. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134777 · Cited by 40 · see citing works

Mechanism of ferroptosis in breast cancer and research progress of natural compounds regulating ferroptosis

Ge, A., He, Q., Da, Z., Li, Y., Chen, J., Deng, Y., Xiang, W., Fan, H., Wu, S., Li, Y., et al. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18044 · Cited by 38 · see citing works

Plant Exosome-like Nanovesicles and Their Role in the Innovative Delivery of RNA Therapeutics

Chen, Y., & Cai, Q. (2023) · Biomedicines · doi:10.3390/biomedicines11071806 · Cited by 38 · see citing works

Extracellular vesicles and exosome-like nanovesicles as pioneering oral drug delivery systems

Mondal, J., Pillarisetti, S., Junnuthula, V., Surwase, S. S., Hwang, S. R., Park, I., & Lee, Y.-K. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1307878 · Cited by 38 · see citing works

Plant-derived exosome-like nanoparticles in tissue repair and regeneration

Gao, C., Chen, Y., Wen, X., Han, R., Qin, Y., Li, S., Tang, R., Zhou, W., Zhao, J., Sun, J., et al. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb02394c · Cited by 38 · see citing works

The use of plant-derived exosome-like nanoparticles as a delivery system of CRISPR/Cas9-based therapeutics for editing long non-coding RNAs in cancer colon cells

Hillman, T. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1194350 · Cited by 38 · see citing works

Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in Hamp KO Mice

Wang, X., Zhang, M., Woloshun, R. R., Yu, Y., Lee, J. K., Flores, S. R., Merlin, D., & Collins, J. F. (2021) · Nutrients · doi:10.3390/nu13051686 · Cited by 37 · see citing works

Plant-derived nanoparticles and plant virus nanoparticles: Bioactivity, health management, and delivery potential

Liu, C., Yu, Y., Fang, L., Wang, J., Sun, C., Li, H., Zhuang, J., & Sun, C. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2204375 · Cited by 34 · see citing works

Animal Models of Normal and Disturbed Iron and Copper Metabolism

Wang, X., Garrick, M. D., & Collins, J. F. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz172 · Cited by 35 · see citing works

Curcumae Rhizoma Exosomes-like nanoparticles loaded Astragalus components improve the absorption and enhance anti-tumor effect

Yang, X., Peng, Y., Wang, Y.-E., Yuxiu, Z., He, Y., Pan, J., Liu, N., Xu, Y., Ma, R., Zhai, J., et al. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104274 · Cited by 33 · see citing works

Engineered plant extracellular vesicles for natural delivery across physiological barriers

Wang, Y., Wu, Y., Shen, S. Q., Liu, Y., Xia, Y., Xia, H., Xie, Z., & Xu, Y. (2024) · Food & Function · doi:10.1039/d3fo03503d · Cited by 31 · see citing works

Efficacy of Rose Stem Cell‐Derived Exosomes ( RSCEs ) in Skin Treatment: From Healing to Hyperpigmentation Management: Case Series and Review

Majewska, L., Dorosz, K., & Kijowski, J. (2025) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16776 · Cited by 30 · see citing works

Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles

Tinnirello, V., Ganji, N. R., Lousa, C. D. M., Alessandro, R., & Raimondo, S. (2023) · Plants · doi:10.3390/plants12061207 · Cited by 29 · see citing works

Development of rice bran-derived nanoparticles with excellent anti-cancer activity and their application for peritoneal dissemination

Sasaki, D., Suzuki, H., Kusamori, K., Itakura, S., Todo, H., & Nishikawa, M. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02381-z · Cited by 31 · see citing works

Gouqi-derived Nanovesicles (GqDNVs) promoted MC3T3-E1 cells proliferation and improve fracture healing

Xu, S., Zhang, Z., Zhou, X., Liao, Y., Peng, Z., Meng, Z., Nussler, A. K., Ma, L., Xia, H., Liu, L., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156755 · Cited by 29 · see citing works

Ginger-derived exosome-like nanoparticles: a representative of plant-based natural nanostructured drug delivery system

Liu, H., Deng, Y., Li, J., Lin, W., Liu, C., Yang, X., Zhou, Z., & Jiang, Y. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1569889 · Cited by 29 · see citing works

Iron uptake mediated by the plant-derived chelator nicotianamine in the small intestine

Murata, Y., Yoshida, M., Sakamoto, N., Morimoto, S., Watanabe, T., & Namba, K. (2021) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015861 · Cited by 29 · see citing works

Prospects of plant-derived exosome-like nanocarriers in oncology and tissue engineering

Rahmati, S., Karimi, H., Alizadeh, M., Khazaei, A. H., Paiva‐Santos, A. C., Rezakhani, L., & Sharifi, E. (2023) · Human Cell · doi:10.1007/s13577-023-00994-4 · Cited by 29 · see citing works

Unleashing the Potential of Oral Deliverable Nanomedicine in the Treatment of Inflammatory Bowel Disease

Yang, C., Sharma, K., Mow, R. J., Bolay, E., Srinivasan, A., & Merlin, D. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.03.005 · Cited by 25 · see citing works

Characterization and Duodenal Transcriptome Analysis of Chinese Beef Cattle With Divergent Feed Efficiency Using RNA-Seq

Yang, C., Han, L., Li, P., Ding, Y., Zhu, Y., Huang, Z., Dan, X., Shi, Y., & Kang, X. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.741878 · Cited by 24 · see citing works

Inhibitors of Human Divalent Metal Transporters DMT1 (SLC11A2) and ZIP8 (SLC39A8) from a GDB‐17 Fragment Library

Pujol‐Giménez, J., Poirier, M., Bühlmann, S., Schuppisser, C., Bhardwaj, R., Awale, M., Visini, R., Javor, S., Hediger, M. A., & Reymond, J. (2021) · ChemMedChem · doi:10.1002/cmdc.202100467 · Cited by 21 · see citing works

Advances in Plant-Derived Extracellular Vesicles: Implications for Apple-Derived EVs

Fu, H., Yong, S., Song, Y., Dang, J., Jing, D., Wu, D., & Guo, Q. (2025) · Plants · doi:10.3390/plants14223425 · Cited by 19 · see citing works

The emerging role of medical foods and therapeutic potential of medical food-derived exosomes

Hur, J.-Y., Lee, S., Shin, W.-R., Kim, Y.-H., & Ahn, J.-Y. (2023) · Nanoscale Advances · doi:10.1039/d3na00649b · Cited by 7 · see citing works

Four AAs increase DMT1 abundance in duodenal brush-border membrane vesicles and enhance iron absorption in iron-deprived mice

Woloshun, R. R., Yu, Y., Xu, X., Lee, J. K., Zhu, S., Shine, J. S., Ebea, P. O., Stevens, B. R., Vidyasagar, S., & Collins, J. F. (2022) · Blood Advances · doi:10.1182/bloodadvances.2021005111 · Cited by 12 · see citing works

Prevention of Ulcerative Colitis by Autologous Metabolite Transfer from Colitogenic Microbiota Treated with Lipid Nanoparticles Encapsulating an Anti-Inflammatory Drug Candidate

Yang, C., Sung, J. J., Long, D., Alghoul, Z., & Merlin, D. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061233 · Cited by 12 · see citing works

Cloudberry-derived nanovesicles as stable oral drug delivery systems: gastrointestinal stability and age-related biodistribution in mice

Shanthi, K. B., Pratiwi, F. W., Naillat, F., Mammadova, R., Sarpola, M., Wu, S., Suokas, M., Jokipii‐Lukkari, S., Kaisto, S., Samoylenko, A., et al. (2025) · Nanoscale · doi:10.1039/d4nr04694c · Cited by 11 · see citing works

Frontiers of Plant-derived Exosomes from Research Methods to Pharmaceutical Applications in Plant-based Therapeutics

Fu, W., Zhang, P., Wang, W., Du, M., Ni, R., & Sun, Y. (2024) · Current Drug Delivery · doi:10.2174/0115672018305953240606063911 · Cited by 11 · see citing works

Advances in plant-derived vesicle like nanoparticles-based therapies for inflammatory diseases

Cheng, Z., Lu, W., Shao, W., Zhang, C., She, Y., Song, R., Qi, R., Song, J., Zhang, W., Chang, X., et al. (2025) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2025.101052 · Cited by 11 · see citing works

Glycochenodeoxycholate Affects Iron Homeostasis via Up-Regulating Hepcidin Expression

Wang, L.-J., Zhao, G., Wang, X.-F., Liu, X., Li, Y., Qiu, L.-L., Wang, X., & Ren, F. (2022) · Nutrients · doi:10.3390/nu14153176 · Cited by 12 · see citing works

Site-specific intestinal DMT1 silencing to mitigate iron absorption using pH-sensitive multi-compartmental nanoparticulate oral delivery system

Fan, Y., Dhaliwal, H. K., Menon, A. V., Chang, J., Choi, J. E., Amiji, M. M., & Kim, J. (2019) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2019.102091 · Cited by 11 · see citing works

Plant-derived extracellular vesicles in diabetic wound healing: mechanisms, therapeutic implications and future perspectives

Xu, J., Zimo, Y., Yuhan, D., Zhongyu, X., Kewei, Z., & Xiaolan, C. (2025) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-025-06961-9 · Cited by 12 · see citing works

Advances of Chinese medicine-derived exosomes in disease intervention and drug delivery system

Zhang, X., Chen, M., Zhu, H., Zhang, J., Wang, X., Chen, W., Mao, Y. V., Jiang, M., Wang, H.-N., Xu, P., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157104 · Cited by 10 · see citing works

Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation

Poirier, M., Pujol‐Giménez, J., Manatschal, C., Bühlmann, S., Embaby, A., Javor, S., Hediger, M. A., & Reymond, J. (2020) · RSC Medicinal Chemistry · doi:10.1039/d0md00085j · Cited by 9 · see citing works

Atomic Force Microscopy to Characterize Ginger Lipid-Derived Nanoparticles (GLDNP)

Long, D., Yang, C., Sung, J. J., & Merlin, D. (2021) · BIO-PROTOCOL · doi:10.21769/bioprotoc.3969 · Cited by 8 · see citing works

Food-derived exosomes as the future of drug delivery

Yang, B., Zhang, M., Yue, L., Zhang, N., Wei, H., Zhang, H., Wang, B., & Liu, P. (2024) · Nano Research · doi:10.1007/s12274-024-6961-2 · Cited by 7 · see citing works

An investigation of nano- and micron-sized carriers based on calcium carbonate and polylactic acid for oral administration of siRNA

Akhmetova, D. R., Rogova, A. S., Tishchenko, Y. A., Mitusova, K. A., Postovalova, A. S., Dovbysh, O. V., Gavrilova, N. V., Epifanovskaya, O. S., Pyatiizbyantsev, T. A., Shakirova, A. I., et al. (2024) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2024.2393244 · Cited by 6 · see citing works

Plant-derived extracellular vesicles as bioactive nanoplatforms: Biogenesis, therapeutic evidence, and translational challenges

Yu, J., Shen, Y., & Jia, H. (2026) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2026.102688 · Cited by 5 · see citing works

Intestinal iron absorption is appropriately modulated to match physiological demand for iron in wild-type and iron-loaded Hamp (hepcidin) knockout rats during acute colitis

Flores, S. R., Nelson, S., Woloshun, R. R., Wang, X., Ha, J., Lee, J. K., Yu, Y., Merlin, D., & Collins, J. F. (2021) · PLoS ONE · doi:10.1371/journal.pone.0252998 · Cited by 5 · see citing works

Extracellular vesicles (exosomes) in prokaryotic organisms: role in their biology and realization of their pathogen potential

Ba, S., Sinitsa, A. B., Zakharchenko, M. M., & Ei, T. (2020) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-179-7-118-130 · Cited by 5 · see citing works

Prevention of Colitis-Associated Cancer via Oral Administration of M13-Loaded Lipid Nanoparticles

Long, D., Alghoul, Z., Sung, J. J., Yang, C., & Merlin, D. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15092331 · Cited by 5 · see citing works

Engineered Plant-Derived Extracellular Vesicles: A Novel Strategy for Tumor-Targeted Therapy

Zuo, Y., Zhang, J. J., Wang, X., Sun, B., Tian, S., & Miao, M. S. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18050577 · Cited by 4 · see citing works

Exploring the Impact of Iron Overload on Mitochondrial DNA in β-Thalassemia: A Comprehensive Review

Narahari, J. M., Guruswamy, P., Jagadeesha, N. M., Shivashakar, K. K., Kumar, D. P., Narayana, P. S., Vishwanath, P. M., & Prashant, A. (2024) · Gene Expression · doi:10.14218/ge.2023.00128 · Cited by 4 · see citing works

Oral Epimedium nanovesicles promote hematopoietic stem cell regeneration via gut-microbiota-bone marrow axis to mitigate chemotherapy-induced myelosuppression

Xie, J., Lan, H., Ma, H., Jiang, D., Yao, H., Su, Y., He, J., Huang, W., Li, T., Shen, Y., et al. (2025) · Nano Research · doi:10.26599/nr.2025.94908148 · Cited by 3 · see citing works

Plant-derived extracellular vesicles: emerging carriers for ingestible nucleotide delivery

Li, Z., Jin, W., Zhu, M., Feng, Y., Fan, G., Zhao, J., Lee, J. S., Li, X., Li, Y., Lu, Y., et al. (2025) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2025.2591237 · Cited by 3 · see citing works

Uric Acid Induces Hepatocytes Ferroptosis Through HIF-2α/DMT1-Mediated Iron Overload

Wang, T., Zheng, W., Guo, M., Cao, J., Wang, L., How, M. S. K., Xu, Y., & Lu, W. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062833 · Cited by 3 · see citing works

Treatment of Obesity Through Glial Cell-Derived Neurotrophic Factor Lipid Nanoparticle Delivery in Mice

Yang, C., Mwangi, S. M., Balasubramaniam, A., Li, G., Merlin-Zhang, O., Liu, Y., & Srinivasan, S. (2023) · Gastro Hep Advances · doi:10.1016/j.gastha.2023.08.012 · Cited by 3 · see citing works

In vivo silencing of intestinal DMT1 mitigates iron loading in β-thalassemia intermedia (Hbbth3/+) mice

Yu, Y., Woloshun, R. R., Lee, J. K., Ebea, P. O., Shine, J. S., Zhu, S., He, Y., & Collins, J. F. (2024) · Blood Advances · doi:10.1182/bloodadvances.2024013333 · Cited by 3 · see citing works

A brief overview on current status of nanomedicines for treatment of pancytopenia: Focusing on chemotherapeutic regime

Karwasra, R., Singh, S., Raza, K., Sharma, N., & Varma, S. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.102159 · Cited by 3 · see citing works

Managing Iron Overload: A Gut Check

Garrick, M. D. (2023) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.123.001645 · Cited by 3 · see citing works

Mono-metallic, Bi-metallic and Tri-metallic Biogenic Nanoparticles Derived from Garlic and Ginger with their Applications

Farooq, S., Munawar, M. A., & Ngaini, Z. (2023) · Current Organic Chemistry · doi:10.2174/1385272827666230915103130 · Cited by 3 · see citing works

Indoor Dust Increases the Risk of Iron-Loading Anemia in Mice through Exogenous Iron-Induced Ineffective Erythropoiesis

Ren, L., Hou, G., Ma, L., Wang, H., Ku, T., Li, G., & Sang, N. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c03663 · Cited by 2 · see citing works

Plant-Derived Exosomes in Aesthetic Medicine

Chen, R., Wei, S., Dan, X., Li, S. S., Chen, H., Pu, Y., Liu, X., Li, T., Lei, L., Li, Y., et al. (2026) · Biomaterials Research · doi:10.34133/bmr.0397 · Cited by 2 · see citing works

Iron Overload Accompanying Extracellular Acidosis and NeurodegenerationPreprint

Ingrassia, R., & Garrick, M. D. (2024) · Preprints.org · doi:10.20944/preprints202406.0882.v1 · Cited by 1 · see citing works

High intestinal iron absorption induced by decreased hepcidin leads to imbalance of iron metabolism in aging mice

Qiu, L., Xiong, W., Qin, X., Zhou, J., Zhu, Y., & Wang, X. (2025) · Biogerontology · doi:10.1007/s10522-025-10374-0 · Cited by 1 · see citing works

Unveiling the Potential of Plant-derived Exosomes: A Comprehensive Review

Jaiswal, S., Sethi, M., Rana, R., Tripathi, S., Trivedi, A. K., & Chourasia, M. K. (2026) · AAPS PharmSciTech · doi:10.1208/s12249-026-03407-5 · Cited by 1 · see citing works

Plant-Derived Nanovesicles: A Comprehensive Review from Isolation to Clinical Translation—Unlocking Natural Nanocarriers for Biomedical Applications

Wang, X., Yuan, C., & Lu, R. (2026) · Biomolecules · doi:10.3390/biom16050705 · Cited by 1 · see citing works

Impact of Biscuit Fortified with Iron Nanoparticles as Food Supplement on Anemia in Albino Rat Model

Morsy, M. K., Osman, A. G. M., El-Desouky, A., Mohamed, M. M., & Aboud, A. A. (2022) · Egyptian Journal of Chemistry · doi:10.21608/ejchem.2022.118578.5338 · Cited by 1 · see citing works

Development of Corn-Derived Nanoparticles as Mass-Producible Bionanoparticles with Anticancer ActivityPreprint

Sasaki, D., Kusamori, K., & Nishikawa, M. (2021) · Research Square · doi:10.21203/rs.3.rs-709895/v1

Recent Progress in Nanoemulsion Technology for the Management of Hepatic Diseases

Sarthi, S., Bhardwaj, H., & Jangde, R. (2024) · Current Nanomedicine · doi:10.2174/0124681873323497240922153222

The therapeutic potential of nanoencapsulated anti-inflammatory drugs delivered to the gut

Li, W., Qiu, L., & Wang, X. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2457321

An amino acid transporter in the small intestine mediates basolateral efflux of plant-derived nicotianamine iron complexes

Murata, Y., Fujisawa, M., Watanabe, T., Matsubara, S., Takase, Y., Takahashi, T., Namba, K., Yamagata, A., & Terada, T. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110731

Additional file 1 of Development of rice bran-derived nanoparticles with excellent anti-cancer activity and their application for peritoneal dissemination

Sasaki, D., Suzuki, H., Kusamori, K., Itakura, S., Todo, H., & Nishikawa, M. (2024) · Figshare · doi:10.6084/m9.figshare.26694252

Plant-Derived Extracellular Vesicles: Sustainable Nanocarriers for Drug Delivery

Bhutta, N. K., Shah, S. S. T. H., Javeed, A., & Han, B. (2026) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/s44411-026-00560-y

Comparative analysis of horsetail and lavender-derived nanovesicles in wound healing and antioxidant defense

Aşık, S., Okay, A., Karaca, B., Derkuş, B., Eylem, C. C., Nemutlu, E., Aras, E. S., & Büyük, İ. (2026) · BMC Biotechnology · doi:10.1186/s12896-026-01146-w

Plant‐Derived Exosome‐Like Nanoparticle miRNAs Can Prevent and Treat Colorectal Cancer by Modulating the Gut Microbiota

Hillman, T. (2026) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1155/jcpt/9727196

From Paramural Structures to Re-Engineered Nanocarriers: Progress and Limitations of Green Nanovesicles in Drug Delivery

Shabbir, A. S., & Dad, H. A. (2026) · ACS Nano Medicine · doi:10.1021/acsnanomed.5c00205

Plant-derived extracellular vesicles as emerging cardioprotective agents for cardiovascular diseases

Li, Q., Wang, Z., Huang, Q.-Y., Zheng, N., Zhai, B., Guo, D., Zou, J., Shi, Y., & Luan, F. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04765-9 · Cited by 2 · see citing works

Nature-derived exosome-like nanoparticles (NELNs) for intracellular transport and targeted RNA delivery

Xu, B., Yang, H., Chen, K. X., Wang, L., Fan, J., 杜垬, Guo, W., Ruan, R. R., Yan, X., Yin, Y., et al. (2026) · Biotechnology Advances · doi:10.1016/j.biotechadv.2026.108979

Emerging role of plant-derived extracellular vesicles in human health and disease

Charishma, K., Musarikandy, R. M., Palanisamy, B., & Mandal, A. K. A. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119953

BindingDB Entry 50012008: Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation.

BindingDB (2022) · UC San Diego · doi:10.7270/q2j96b1j

Oral Delivery of Dmt1 siRNAs by Ginger Nanoparticle‐derived Lipid Vectors Mitigates Iron Loading in Hepcidin KO Mice

Wang, X., Zhang, M., Flores, S. R., Woloshun, R. R., Yang, C., Yin, L., Xiang, P., Xu, X., Garrick, M. D., Vidyasagar, S., et al. (2019) · The FASEB Journal · doi:10.1096/fasebj.2019.33.1_supplement.lb551

Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in Hamp KO Mice

Wang, X., Zhang, M., Woloshun, R. R., Yu, Y., Lee, J. K., Flores, S. R., Merlin, D., & Collins, J. F. (2021) · Nutrients · doi:10.3390/nu13051686 · Cited by 37 · see citing works

Intestinal Dmt1 is Required for Iron Loading in Mice Modeling β‐Thalassemia Intermedia

Yu, Y., Yang, C., Shine, J. S., Lee, J. K., Ebea, P. O., Zhu, S., Merlin, D., & Collins, J. F. (2022) · The FASEB Journal · doi:10.1096/fasebj.2022.36.s1.r1912

Site-specific intestinal DMT1 silencing to mitigate iron absorption using pH-sensitive multi-compartmental nanoparticulate oral delivery system

Fan, Y., Dhaliwal, H. K., Menon, A. V., Chang, J., Choi, J. E., Amiji, M. M., & Kim, J. (2019) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2019.102091 · Cited by 11 · see citing works

In vivo silencing of intestinal DMT1 mitigates iron loading in β-thalassemia intermedia (Hbbth3/+) mice

Yu, Y., Woloshun, R. R., Lee, J. K., Ebea, P. O., Shine, J. S., Zhu, S., He, Y., & Collins, J. F. (2024) · Blood Advances · doi:10.1182/bloodadvances.2024013333 · Cited by 3 · see citing works