Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis
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We previously reported that mice made deficient for the transcriptional factor USF2 fail to express hepcidin 1 and hepcidin 2 genes as a consequence of targeted disruption of the Usf2 gene lying just upstream in the locus. These mice developed an iron overload phenotype with excess iron deposition in parenchymal cells and decreased reticuloendothelial iron. At that time, although the role of USF2 was still confounding, we proposed for the first time the role of hepcidin as a negative regulator of iron absorption and iron release from macrophages. Accordingly, we subsequently demonstrated that hyperexpression of hepcidin 1, but not hepcidin 2, resulted in a profound hyposideremic anemia. To analyze the consequences of hepcidin 1 deletion on iron metabolism without any disturbance due to USF2 deficiency, we disrupted the hepcidin 1 gene by targeting almost all the coding region. Confirming our prior results, Hepc1–/– mice developed early and severe multivisceral iron overload, with sparing of the spleen macrophages, and demonstrated increased serum iron and ferritin levels as compared with their controls.
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Hepcidin acts as a negative regulator of iron efflux by causing internalisation of ferroportin.
“that acts in part as a negative regulator of iron efflux [328] by causing the internalisation of ferroportin [329-333].”
Hamp−/− mice present higher hematocrit (60%) and higher concentrations of iron and ferritin in blood compared to WT mice.
“As previously described (14), Hamp−/− mice present a higher hematocrit (60%) and a higher concentration of iron and ferritin in the blood when compared to WT (Figures 3A–C).”
From Iron- and Hepcidin-Independent Downregulation of the Iron Exporter Ferroportin in Macrophages during Salmonella Infection (2017) · cites this paper as [14]
Hamp−/− mice develop a specific iron phenotype with high serum iron concentration, excess iron deposition in hepatocytes, and low iron levels in tissue macrophages.
“Hamp−/− mice have been shown to develop a specific iron phenotype with high serum iron concentration, excess iron deposition in hepatocytes, and low iron levels in tissue macrophages (14).”
From Iron- and Hepcidin-Independent Downregulation of the Iron Exporter Ferroportin in Macrophages during Salmonella Infection (2017) · cites this paper as [14]
Suppression of hepcidin alone cannot fully explain the polycythemia associated with testosterone administration.
“The suppression of hepcidin alone cannot fully explain the polycythemia associated with testosterone administration because hemochromatosis patients with inactivating mutations in the hepcidin gene (hAMP) and mice with disruption of the hepcidin gene expression do not display a phenotype of polycythemia (27,28).”
From Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point (2014) · cites this paper as [27]
Inactivation of the hepcidin gene in mice is associated with severe iron overload.
“The functional effects of altered hepcidin expression in vivo were apparent when Nicolas, Lesbordes-Brion, and colleagues showed that inactivation of the hepcidin gene in mice was associated with severe iron overload.101,102”
From Forging a field: the golden age of iron biology. (2008) · cites this paper as [102]
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Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803 · see citing works
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650 · see citing works
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168 · see citing works
Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., & Loréal, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008923200 · Cited by 1,697 · see citing works
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
Ganz, T. (2003) · Blood · doi:10.1182/blood-2003-03-0672 · Cited by 1,544 · see citing works
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., & Ganz, T. (2003) · Blood · doi:10.1182/blood-2002-10-3235 · Cited by 1,417 · see citing works
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
Krause, A., Neitz, S., Mägert, H.-J., Schulz, A., Forssmann, W.-G., Schulz-Knappe, P., & Adermann, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01920-7 · Cited by 1,324 · see citing works
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
Donovan, A., Lima, C. A., Pinkus, J. L., Pinkus, G. S., Zon, L. I., Robine, S., & Andrews, N. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.003 · Cited by 1,275 · see citing works
Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A., & Vaulont, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151179498 · Cited by 1,233 · see citing works
Self-citationNicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215686 · Cited by 1,214 · see citing works
Self-citationSevere iron deficiency anemia in transgenic mice expressing liver hepcidin
Nicolas, G., Bennoun, M., Porteu, A., Mativet, S., Beaumont, C., Grandchamp, B., Sirito, M., Sawadogo, M., Kahn, A., & Vaulont, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072632499 · Cited by 880 · see citing works
Self-citationKnutson, M. D., Oukka, M., Koss, L. M., Aydemir, F., & Wessling-Resnick, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409409102 · Cited by 479 · see citing works
Hepcidin—a regulator of intestinal iron absorption and iron recycling by macrophages
GANZ, T. (2005) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2004.08.020 · Cited by 393 · see citing works
Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
Niederkofler, V. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25683 · Cited by 368 · see citing works
A mouse model of juvenile hemochromatosis
Huang, F. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25049 · Cited by 363 · see citing works
Hepcidin, A New Iron Regulatory Peptide
Nicolas, G., Viatte, L., Bennoun, M., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2002.0573 · Cited by 348 · see citing works
Self-citationDelaby, C., Pilard, N., Gonçalves, A. S., Beaumont, C., & Canonne-Hergaux, F. (2005) · Blood · doi:10.1182/blood-2005-06-2398 · Cited by 283 · see citing works
Torrance, J. D. (1980) · Medical Entomology and Zoology · Cited by 219 · see citing works
Functional differences between hepcidin 1 and 2 in transgenic mice
Lou, D.-Q., Nicolas, G., Lesbordes, J.-C., Viatte, L., Grimber, G., Szajnert, M.-F., Kahn, A., & Vaulont, S. (2004) · Blood · doi:10.1182/blood-2003-07-2524 · Cited by 123 · see citing works
Self-citationRegulation of iron absorption in Hfe mutant mice
Ajioka, R. S., Levy, J. E., Andrews, N. C., & Kushner, J. P. (2002) · Blood · doi:10.1182/blood-2001-11-0037 · Cited by 95 · see citing works
Kress, C., Vandormael‐Pournin, S., Baldacci, P. A., Cohen‐Tannoudji, M., & Babinet, C. (1998) · Mammalian Genome · doi:10.1007/s003359900914 · Cited by 78 · see citing works
New insights into iron homeostasis through the study of non-HFE hereditary haemochromatosis
Roetto, A., & Camaschella, C. (2005) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2004.09.004 · Cited by 55 · see citing works
Flagged first, then by citations
1 of the 23 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Two to tango: Regulation of Mammalian iron metabolism
Hentze, M. W., Muckenthaler, M. U., Galy, B., & Camaschella, C. (2010) · Cell · doi:10.1016/j.cell.2010.06.028 · Cited by 2,120 · see citing works
Ganz, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00008.2013 · Cited by 1,122 · see citing works
The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease
Fang, X., Ardehali, H., Min, J., & Wang, F. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00735-4 · Cited by 1,096 · see citing works
Drakesmith, H., Nemeth, E., & Ganz, T. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.09.006 · Cited by 638 · see citing works
Forging a field: the golden age of iron biology.
Andrews, N. C. (2008) · Blood · doi:10.1182/blood-2007-12-077388 · Cited by 623 · see citing works
Lack of the bone morphogenetic protein BMP6 induces massive iron overload
Meynard, D., Kautz, L., Darnaud, V., Canonne-Hergaux, F., Coppin, H., & Roth, M.-P. (2009) · Nature Genetics · doi:10.1038/ng.320 · Cited by 587 · see citing works
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works
Regulation of the Iron Homeostatic Hormone Hepcidin
Sangkhae, V., & Nemeth, E. (2017) · Advances in Nutrition · doi:10.3945/an.116.013961 · Cited by 446 · see citing works
Kautz, L., Meynard, D., Monnier, A., Darnaud, V., Bouvet, R., Wang, R.-H., Deng, C., Vaulont, S., Mosser, J., Coppin, H., et al. (2008) · Blood · doi:10.1182/blood-2008-03-143354 · Cited by 437 · see citing works
Self-citationBachman, E., Travison, T. G., Basaria, S., Davda, M. N., Guo, W., Li, M., Connor Westfall, J., Bae, H., Gordeuk, V., & Bhasin, S. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glt154 · Cited by 426 · see citing works
Iron uptake and metabolism in the new millennium
Dunn, L., Rahmanto, Y. S., & Richardson, D. R. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.12.003 · Cited by 419 · see citing works
Iron metabolism in the anemia of chronic disease
Weiss, G. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.08.006 · Cited by 322 · see citing works
Hepcidin: from discovery to differential diagnosis
Kemna, E., Tjalsma, H., Willems, H. L., & Swinkels, D. W. (2007) · Haematologica · doi:10.3324/haematol.11705 · Cited by 313 · see citing works
Miura, K., Taura, K., Kodama, Y., Schnabl, B., & Brenner, D. A. (2008) · Hepatology · doi:10.1002/hep.22486 · Cited by 270 · see citing works
Taylor, M., Qu, A., Anderson, E. R., Matsubara, T., Martin, A., Gonzalez, F. J., & Shah, Y. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.03.007 · Cited by 265 · see citing works
The Regulation of Iron Absorption and Homeostasis.
Wallace, D. F. (2016) · PubMed Central · Cited by 255 · see citing works
Sasu, B. J., Cooke, K. S., Arvedson, T. L., Plewa, C., Ellison, A. R., Sheng, J., Winters, A., Juan, T., Li, H., Begley, C. G., et al. (2010) · Blood · doi:10.1182/blood-2009-09-245977 · Cited by 251 · see citing works
Jenkitkasemwong, S., Wang, C.-Y., Coffey, R., Zhang, W., Chan, A., Biel, T., Kim, J.-S., Hojyo, S., Fukada, T., & Knutson, M. D. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.002 · Cited by 245 · see citing works
Molecular Mechanisms of Hepcidin Regulation: Implications for the Anemia of CKD
Babitt, J. L., & Lin, H. Y.-F. (2010) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2009.12.030 · Cited by 236 · see citing works
Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function
Lakhal-Littleton, S., Wolna, M., Carr, C. A., Miller, J. J. J., Christian, H. C., Ball, V., Santos, A., Diaz, R., Biggs, D., Stillion, R., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422373112 · Cited by 234 · see citing works
Preza, G. C., Ruchala, P., Pinon, R., Ramos, E., Qiao, B., Peralta, M. A., Sharma, S., Waring, A., Ganz, T., & Nemeth, E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57693 · Cited by 234 · see citing works
Arezes, J., Jung, G., Gabayan, V., Valore, E., Ruchala, P., Gulig, P. A., Ganz, T., Nemeth, E., & Bulut, Y. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2014.12.001 · Cited by 227 · see citing works
Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia
Ramos, P., Casu, C., Gardenghi, S., Breda, L., Crielaard, B. J., Guy, E., Marongiu, M. F., Gupta, R., Levine, R. L., Abdel-Wahab, O., et al. (2013) · Nature Medicine · doi:10.1038/nm.3126 · Cited by 227 · see citing works
Anderson, E. R., & Shah, Y. M. (2012) · Comprehensive physiology · doi:10.1002/cphy.c120016 · Cited by 249 · see citing works
Lawen, A., & Lane, D. J. R. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4271 · Cited by 217 · see citing works
Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice
Canali, S., Zumbrennen‐Bullough, K. B., Core, A. B., Wang, C., Nairz, M., Bouley, R., Świrski, F. K., & Babitt, J. L. (2016) · Blood · doi:10.1182/blood-2016-06-721571 · Cited by 214 · see citing works
Minihepcidins prevent iron overload in a hepcidin-deficient mouse model of severe hemochromatosis
Ramos, E., Ruchala, P., Goodnough, J. B., Kautz, L., Preza, G. C., Nemeth, E., & Ganz, T. (2012) · Blood · doi:10.1182/blood-2012-07-440743 · Cited by 213 · see citing works
Singh, N., Haldar, S., Tripathi, A. K., Horback, K., Wong, J., Sharma, D., Beserra, A., Suda, S., Anbalagan, C., Dev, S., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4931 · Cited by 205 · see citing works
Effects of maternal iron status on placental and fetal iron homeostasis
Sangkhae, V., Fisher, A. L., Wong, S., Koenig, M. D., Tussing-Humphreys, L., Chu, A., Lelić, M., Ganz, T., & Nemeth, E. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127341 · Cited by 198 · see citing works
Hepcidin targets ferroportin for degradation in hepatocytes
Ramey, G., Deschemin, J., Durel, B., Canonne‐Hergaux, F., Nicolas, G., & Vaulont, S. (2009) · Haematologica · doi:10.3324/haematol.2009.014399 · Cited by 193 · see citing works
Self-citationIron homeostasis: An anthropocentric perspective
Coffey, R., & Ganz, T. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.781823 · Cited by 189 · see citing works
Hypoxia-inducible factors link iron homeostasis and erythropoiesis
Shah, Y. M., & Xie, L. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.12.031 · Cited by 187 · see citing works
Role of iron metabolism in heart failure: From iron deficiency to iron overload
Zhang, H., Zhabyeyev, P., Wang, S., & Oudit, G. Y. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.030 · Cited by 185 · see citing works
Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice
Steinbicker, A. U., Bartnikas, T. B., Isbell, L. K., Leyton, P., Mayeur, C., Kao, S. M., Pappas, A. E., Peterson, R. T., Bloch, D. B., Yu, P. B., et al. (2011) · Blood · doi:10.1182/blood-2011-03-339952 · Cited by 181 · see citing works
Regulation of Iron Metabolism by Hepcidin under Conditions of Inflammation
Schmidt, P. J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.650150 · Cited by 181 · see citing works
Regulation of Hepcidin and Iron-Overload Disease
Lee, P. L., & Beutler, E. (2009) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092205 · Cited by 174 · see citing works
The FBXL5-IRP2 Axis Is Integral to Control of Iron Metabolism In Vivo
Moroishi, T., Nishiyama, M., Takeda, Y., Iwaï, K., & Nakayama, K. I. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.07.011 · Cited by 163 · see citing works
Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia
Nai, A., Pagani, A., Mandelli, G., Lidonnici, M. R., Silvestri, L., Ferrari, G., & Camaschella, C. (2012) · Blood · doi:10.1182/blood-2012-01-401885 · Cited by 161 · see citing works
Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin
Lim, P. J., Duarte, T. L., Arezes, J., Garcia-Santos, D., Hamdi, A., Pasricha, S.-R., Armitage, A. E., Mehta, H., Wideman, S., Santos, A. G., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0063-6 · Cited by 147 · see citing works
A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin
Kim, A., Fung, E., Parikh, S. G., Valore, E. V., Gabayan, V., Nemeth, E., & Ganz, T. (2014) · Blood · doi:10.1182/blood-2013-08-521419 · Cited by 145 · see citing works
Hepcidin Mitigates Renal Ischemia-Reperfusion Injury by Modulating Systemic Iron Homeostasis
Scindia, Y., Dey, P., Thirunagari, A., Liping, H., Rosin, D. L., Floris, M., Okusa, M. D., & Swaminathan, S. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014101037 · Cited by 141 · see citing works
Porto, G. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i35.4707 · Cited by 140 · see citing works
The Regulation of Hepcidin and Its Effects on Systemic and Cellular Iron Metabolism
Fleming, M. D. (2008) · Hematology · doi:10.1182/asheducation-2008.1.151 · Cited by 131 · see citing works
Hepcidin, the hormone of iron metabolism, is bound specifically to α-2-macroglobulin in blood
Pešlová, G., Petrák, J., Kuželová, K., Hrdý, I., Halada, P., Kuchel, P. W., Soe-Lin, S., Ponka, P., Šuťák, R., Becker, E., et al. (2009) · Blood · doi:10.1182/blood-2009-01-201590 · Cited by 127 · see citing works
RETRACTED: The Hepcidin-Binding Site on Ferroportin Is Evolutionarily Conserved
Domenico, I. D., Nemeth, E., Nelson, J. M., Phillips, J. D., Ajioka, R. S., Kay, M. S., Kushner, J. P., Ganz, T., Ward, D. M., & Kaplan, J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.002 · Cited by 127 · see citing works
RetractedIron homeostasis and eye disease
Loh, A. R., Hadziahmetovic, M., & Dunaief, J. L. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.11.001 · Cited by 125 · see citing works
Altamura, S., Kessler, R., Gröne, H.-J., Gretz, N., Hentze, M. W., Galy, B., & Muckenthaler, M. U. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.007 · Cited by 119 · see citing works
Regulation of TMPRSS6 by BMP6 and iron in human cells and mice
Meynard, D., Vaja, V., Sun, C. C., Corradini, E., Chen, S., López-Otı́n, C., Grgurević, L., Hong, C. C., Stirnberg, M., Gütschow, M., et al. (2011) · Blood · doi:10.1182/blood-2011-04-348698 · Cited by 123 · see citing works
Hepcidin – central regulator of iron metabolism
Atanasiu, V., Manolescu, B. N., & Stoian, I. A.-M. (2006) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2006.00772.x · Cited by 123 · see citing works
The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions
Mastrogiannaki, M., Matak, P., & Peyssonnaux, C. (2013) · Blood · doi:10.1182/blood-2012-11-427765 · Cited by 116 · see citing works
Zebrafish in the sea of mineral (iron, zinc, and copper) metabolism
Zhao, L., Xia, Z., & Wang, F. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00033 · Cited by 114 · see citing works
Macrophages and Iron Metabolism
Ganz, T. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0037-2016 · Cited by 108 · see citing works
Gardenghi, S., Renaud, T. M., Meloni, A., Casu, C., Crielaard, B. J., Bystrom, L. M., Greenberg-Kushnir, N., Sasu, B. J., Cooke, K. S., & Rivella, S. (2014) · Blood · doi:10.1182/blood-2013-08-521625 · Cited by 107 · see citing works
Current Approaches to the Management of Hemochromatosis
Brissot, P., & BELS, F. D. (2006) · Hematology · doi:10.1182/asheducation-2006.1.36 · Cited by 107 · see citing works
Wallace, D. F. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i35.4690 · Cited by 101 · see citing works
Wang, X., Zhang, M., Flores, S. R. L., Woloshun, R. R., Yang, C., Yin, L., Xiang, P., Xu, X., Garrick, M. D., Vidyasagar, S., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.01.003 · Cited by 99 · see citing works
Age-Dependent Retinal Iron Accumulation and Degeneration in Hepcidin Knockout Mice
Hadziahmetovic, M., Song, Y., Ponnuru, P., Iacovelli, J., Hunter, A. A., Haddad, N., Beard, J., Connor, J. R., Vaulont, S., & Dunaief, J. L. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6113 · Cited by 98 · see citing works
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Michels, K. R., Zhang, Z., Bettina, A. M., Cagnina, R. E., Stefanova, D., Burdick, M. D., Vaulont, S., Nemeth, E., Ganz, T., & Mehrad, B. (2017) · JCI Insight · doi:10.1172/jci.insight.92002 · Cited by 93 · see citing works
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Lee, D. W., Rajagopalan, S., Siddiq, A., Gwiazda, R. H., Yang, L., Beal, M. F., Ratan, R. R., & Andersen, J. K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.000638 · Cited by 97 · see citing works
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Daher, R., Manceau, H., & Karim, Z. (2017) · La Presse Médicale · doi:10.1016/j.lpm.2017.10.006 · Cited by 91 · see citing works
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Self-citationThe function of heme-regulated eIF2α kinase in murine iron homeostasis and macrophage maturation
Liu, S., Suragani, R. N. V. S., Wang, F., Han, A., Zhao, W., Andrews, N. C., & Chen, J.-J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32084 · Cited by 90 · see citing works
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Qian, Z.-M., He, X., Liang, T., Wu, K.-C., Yan, Y.-C., Lu, L.-N., Yang, G., Luo, Q. Q., Yung, W.-H., & Ke, Y. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8671-3 · Cited by 89 · see citing works
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Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype
Zumerle, S., Mathieu, J. R. R., Delga, S., Heinis, M., Viatte, L., Vaulont, S., & Peyssonnaux, C. (2014) · Blood · doi:10.1182/blood-2014-01-550467 · Cited by 87 · see citing works
Self-citationSchwarz, P., Kübler, J., Strnad, P., Müller, K., Barth, T. F. E., Gerloff, A., Feick, P., Peyssonnaux, C., Vaulont, S., Adler, G., et al. (2011) · Gut · doi:10.1136/gut.2011.241208 · Cited by 86 · see citing works
Self-citationAn important role of the hepcidin–ferroportin signaling in affecting tumor growth and metastasis
Guo, W., Zhang, S., Chen, Y., Zhang, D., Yuan, L., Cong, H., & Liu, S. (2015) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmv063 · Cited by 84 · see citing works
Regulators of hepcidin expression
Roth, M., Meynard, D., & Coppin, H. (2019) · Vitamins and hormones · doi:10.1016/bs.vh.2019.01.005 · Cited by 84 · see citing works
Fan, Y., Liu, B., Chen, F., Song, Z., Han, B., Meng, Y., Hou, J., Cao, P., Chang, Y., & Tan, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.612144 · Cited by 84 · see citing works
Intestinal Iron Homeostasis and Colon Tumorigenesis
Xue, X., & Shah, Y. M. (2013) · Nutrients · doi:10.3390/nu5072333 · Cited by 83 · see citing works
Regulation of Hepcidin by Erythropoiesis: The Story So Far
Pasricha, S., McHugh, K., & Drakesmith, H. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050731 · Cited by 81 · see citing works
Zumbrennen‐Bullough, K. B., & Babitt, J. L. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft443 · Cited by 80 · see citing works
Leishmania-Mediated Inhibition of Iron Export Promotes Parasite Replication in Macrophages
Ben-Othman, R., Flannery, A. R., Miguel, D. C., Ward, D. M., Kaplan, J., & Andrews, N. W. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003901 · Cited by 76 · see citing works
Mayeur, C., Leyton, P. A., Kolodziej, S. A., Yu, B., & Bloch, K. D. (2014) · Blood · doi:10.1182/blood-2014-04-572644 · Cited by 74 · see citing works
Maternal hepcidin determines embryo iron homeostasis in mice
Sangkhae, V., Fisher, A. L., Chua, K. J., Ruchala, P. P., Ganz, T., & Nemeth, E. (2020) · Blood · doi:10.1182/blood.2020005745 · Cited by 73 · see citing works
Lipiński, P., Styś, A., & Starzyński, R. R. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1018-1 · Cited by 73 · see citing works
Stefanova, D., Raychev, A., Deville, J., Humphries, R., Campeau, S., Ruchala, P., Nemeth, E., Ganz, T., & Bulut, Y. (2018) · Infection and Immunity · doi:10.1128/iai.00253-18 · Cited by 68 · see citing works
Hepcidin Deficiency Protects Against Atherosclerosis
Malhotra, R. K., Wunderer, F., Barnes, H. J., Bagchi, A., Buswell, M. D., O’Rourke, C., Slocum, C. L., Ledsky, C. D., Peneyra, K. M., Sigurslid, H. H., et al. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.312215 · Cited by 68 · see citing works
Iron homeostasis: new players, newer insights
Edison, E. S., Bajel, A. R., & Chandy, M. (2008) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2008.01143.x · Cited by 67 · see citing works
Lunová, M., Goehring, C., Kuscuoglu, D., Mueller, K., Chen, Y., Walther, P., Deschemin, J., Vaulont, S., Haybaeck, J., Lackner, C., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.04.034 · Cited by 66 · see citing works
Self-citationCHEN, B., Li, G., Shen, Y., Huang, X., & Xu, Y. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2484 · Cited by 64 · see citing works
Nieuwenhuizen, L., Schutgens, R. E. G., van Asbeck, B. S., Wenting, M. J. G., van Veghel, K., Roosendaal, G., Biesma, D. H., & Lafeber, F. P. J. G. (2013) · Haemophilia · doi:10.1111/hae.12208 · Cited by 63 · see citing works
Catapano, A., Cimmino, F., Petrella, L., Pizzella, A., D’Angelo, M., Ambrosio, K., Marino, F., Sabbatini, A., Petrelli, M. D., Paolini, B., et al. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.109888 · Cited by 66 · see citing works
Song, D., Zhao, L., Li, Y., Hadziahmetovic, M., Song, Y., Connelly, J., Spino, M., & Dunaief, J. L. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-14568 · Cited by 58 · see citing works
Mastrogiannaki, M., Matak, P., Delga, S., Deschemin, J.-C., Vaulont, S., & Peyssonnaux, C. (2012) · Blood · doi:10.1182/blood-2011-09-380337 · Cited by 57 · see citing works
Self-citationDisorders associated with systemic or local iron overload: from pathophysiology to clinical practice
Sebastiani, G., & Pantopoulos, K. (2011) · Metallomics · doi:10.1039/c1mt00082a · Cited by 57 · see citing works
Fader, K. A., Nault, R., Kirby, M. P., Markous, G., Matthews, J., & Zacharewski, T. R. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.02.006 · Cited by 48 · see citing works
Shen, G. S., Yang, Q., Jian, J. L., Zhao, G. Y., Liu, L. L., Wang, X., Zhang, W., Huang, X., & Xu, Y. J. (2014) · Calcified Tissue International · doi:10.1007/s00223-014-9845-8 · Cited by 51 · see citing works
Brown, D. E., Libby, S. J., Moreland, S. M., McCoy, M. W., Brabb, T., Stepanek, A., Fang, F. C., & Detweiler, C. S. (2013) · Veterinary Pathology · doi:10.1177/0300985813478213 · Cited by 48 · see citing works
Lefèbvre, T., Dessendier, N., Houamel, D., Ialy-Radio, N., Kannengiesser, C., Manceau, H., Beaumont, C., Nicolas, G., Gouya, L., Puy, H., et al. (2015) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2014-1093 · Cited by 50 · see citing works
Yuan, Y., Feng, Z., & Wang, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.599439 · Cited by 48 · see citing works
Molecular basis of HFE-hemochromatosis
Vujić, M. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00042 · Cited by 47 · see citing works
Iron at the Interface of Hepatocellular Carcinoma
Paganoni, R., Lechel, A., & Spasić, M. V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084097 · Cited by 48 · see citing works
Regulation of Intestinal Iron Absorption: The Mucosa Takes Control?
Simpson, R. J., & McKie, A. T. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.06.009 · Cited by 47 · see citing works
Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes
Brahmachary, M., Schönbach, C., Yang, L., Huang, E., Tan, S. L., Chowdhary, R., Krishnan, S., Lin, C., Hume, D. A., Kai, C., et al. (2006) · BMC Bioinformatics · doi:10.1186/1471-2105-7-s5-s8 · Cited by 47 · see citing works
Hadziahmetovic, M., Song, Y., Wolkow, N., Iacovelli, J., Kautz, L., Roth, M., & Dunaief, J. L. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.03.033 · Cited by 46 · see citing works
Willemetz, A., Beatty, S., Richer, E., Rubio, A., Auriac, A., Milkereit, R. J., Thibaudeau, O., Vaulont, S., Malo, D., & Canonne-Hergaux, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00498 · Cited by 45 · see citing works
Self-citationMaggio, M. G., Vita, F. D., Fisichella, A., Lauretani, F., Ticinesi, A., Ceresini, G., Cappola, A. R., Ferrucci, L., & Ceda, G. P. (2015) · International Journal of Endocrinology · doi:10.1155/2015/292574 · Cited by 44 · see citing works
Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels
Sterling, J. K., Guttha, S., Song, Y., Song, D., Hadziahmetovic, M., & Dunaief, J. L. (2017) · Experimental Eye Research · doi:10.1016/j.exer.2016.12.008 · Cited by 45 · see citing works
- Authors
- Lesbordes-Brion, J.-C., Viatte, L., Bennoun, M., Lou, D.-Q., Ramey, G., Houbron, C., Hamard, G., Kahn, A., & Vaulont, S.
- Affiliations
- From the Institut Cochin, Département de Génétique, Développement et Pathologie Moléculaire; Institut National de la Santé et de la Recherche Médicale (INSERM) U567; Centre National de la Recherche Scientifique (CNRS); and Université Paris Descartes, Faculté de Médecine René Descartes, Paris, France.
- Centre National de la Recherche Scientifique (FR)
- ORCID
- Vaulont, Sophie
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2006-08-15
- Volume
- 108
- Issue
- 4
- Pages
- 1402-1405
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1987067683
- Cited by
- 257
- References
- 23
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 8 · 2023: 4 · 2022: 9 · 2021: 9 · 2020: 19 · 2019: 13 · 2018: 8 · 2017: 21 · 2016: 16 · 2015: 16 · 2014: 21 · 2013: 19 · 2012: 13
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Keywords
- hemochromatosis, iron overload, iron metabolism, knockout mice, USF2, serum iron, ferritin, splenic macrophages
- MeSH terms
- Animals, Ferritins, Hemochromatosis, Iron, Macrophages, Spleen, Open Reading Frames, Gene Deletion, Mice, Knockout, Antimicrobial Cationic Peptides, Quantitative Trait Loci, Mice, Upstream Stimulatory Factors, Hepcidins
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