Cited by 311Extracellular vesicles in diseaseNanoparticle-Based Drug DeliveryNanoparticles: synthesis and applications

Plant derived edible nanoparticles as a new therapeutic approach against diseases

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Zhang, Mingzhen, Viennois, Emilie, Xu, Changlong, Merlin, Didier·2016·Tissue Barriers

Abstract

In plant cells, nanoparticles containing miRNA, bioactive lipids and proteins serve as extracellular messengers to mediate cell-cell communication in a manner similar to the exosomes secreted by mammalian cells. Notably, such nanoparticles are edible. Moreover, given the proper origin and cargo, plant derived edible nanoparticles could function in interspecies communication and may serve as natural therapeutics against a variety of diseases. In addition, nanoparticles made of plant-derived lipids may be used to efficiently deliver specific drugs. Plant derived edible nanoparticles could be more easily scaled up for mass production, compared to synthetic nanoparticles. In this review, we discuss recent significant developments pertaining to plant derived edible nanoparticles and provide insight into the use of plants as a bio-renewable, sustainable, diversified platform for the production of therapeutic nanoparticles.

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Crossref · 10.1080/21688370.2015.1134415

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  1. [66][66].Fevrier B, Raposo G. Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr Opin Cell Biol 2004; 16:415-21; PMID:15261674; http://dx.doi.org/ 10.1016/j.ceb.2004.06.003 [DOI] [PubMed] [Google Scholar] · DOI

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Authors
Zhang, M., Viennois, E., Xu, C., & Merlin, D.
Affiliations
Georgia State University (US)
Corresponding author
Zhang, Mingzhen
Venue
Tissue Barriers
Published
2016-02-11
Volume
4
Issue
2
Pages
e1134415
ISSN
  • 2168-8362 (ISSN-L)
  • 2168-8370
OpenAlex
W2340580991
Cited by
311
References
78
Citations by year
2026: 34 · 2025: 32 · 2024: 43 · 2023: 44 · 2022: 46 · 2021: 48 · 2020: 27 · 2019: 14 · 2018: 13 · 2017: 5 · 2016: 5
FWCI
1.11
Type
journal article
Language
en
Open access
Locations
  • Tissue Barriers (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Crohn's and Colitis Foundation (329228)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK071594)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
Keywords
extracellular vesicles, microRNA, bioactive lipids, plant proteins, interspecies communication, drug delivery, plant-based therapeutics
MeSH terms
Administration, Oral, Animals, Humans, Plant Extracts, Nanoparticles, Exosomes

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