Making preventive medicine more personalized. Implications for exercise-related research.
Open accessAbstract
Objective This commentary offers a discussion of the need to consider behavioral interventions such as physical exercise as integral components of personalized medicine. Methods We discuss the concept of personalized medicine and review existing evidence of variability in response to exercise training. Results We argue that increased understanding is needed regarding sources of variability in exercise responsiveness, and that such understanding should lead to more tailored, often multimodal interventions. Conclusion Studies of personalized medicine to date have primarily investigated heterogeneity in drug responsiveness; we believe it is time to begin considering preventive strategies such as exercise within a broader scope of personalized care.
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There is large interindividual heterogeneity in psychophysiological responses to acute physical exercises and in long-term adaptations to physical training.
“Based on the large interindividual heterogeneity (i) in psychophysiological responses to acute physical exercises and (ii) in long-term adaptions to a physical training”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Buford and Pahor, 2012
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- Authors
- Buford, T. W., & Pahor, M.
- Affiliations
- University of Florida (US)
- Corresponding author
- Buford, Thomas W.
- ORCID
- Buford, Thomas W.
- Venue
- Preventive Medicine
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 55
- Issue
- 1
- Pages
- 34-36
- ISSN
- 0091-7435 (ISSN-L)
- PMC
- PMC3612277
- OpenAlex
- W2058615952
- Cited by
- 28
- References
- 25
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 7 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 2
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Preventive Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH
- University of Florida Claude D. Pepper Older Americans Independence Center (1P30AG028740)
- Clinical and Translational Science Institute (1KL2RR029888)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- personalized medicine, physical activity, behavioral interventions, multimodal intervention, personalized interventions
- MeSH terms
- Community-Institutional Relations, Health Policy, Health Promotion, Health Services Research, Humans, Organizational Innovation, Outcome and Process Assessment, Health Care, Pharmacogenetics, Physician-Patient Relations, Preventive Medicine, United States, Health Behavior, Exercise, Guideline Adherence, Genomics, Precision Medicine
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