Metabolic syndrome and coronary angiographic disease progression: the Women’s Angiographic Vitamin & Estrogen trial
Abstract
Background The metabolic syndrome is a cluster of clinical characteristics thought to be associated with increased coronary risk. This analysis evaluates angiographic progression of coronary disease in women who are postmenopausal with and without the metabolic syndrome enrolled in the Women's Angiographic Vitamin & Estrogen (WAVE) trial, a randomized, controlled trial of hormone therapy and antioxidant vitamins.Methods A total of 425 women who are postmenopausal and have angiographic coronary disease were enrolled at 7 clinics between July 1997 and August 1999. Women were categorized as having the metabolic syndrome when they met the National Cholesterol Education Program Adult Treatment Panel III definition. Coronary angiograms were performed at baseline and after 2.8 +/- 0.9 years (mean +/- SD). Quantitative coronary angiographic analysis was performed at a core laboratory.Results Women with the metabolic syndrome (177/294, 60%) were more likely to be taking cholesterol-lowering medication (65% vs 51%, P =.01) and had higher body mass index (33 +/- 6 vs 28 +/- 6 kg/m(2), P <.001). The mean reduction in minimum lumen diameter was greater (-0.041 +/- 0.151 vs -0.023 +/- 0.148 mm/year, P =.33) and new lesions were more frequent (34% vs 23%, P =.054) in women with the metabolic syndrome. In multivariate analysis, the metabolic syndrome was not an independent predictor of angiographic disease progression. However, clinical events (myocardial infarction, stroke, or coronary death) were more frequent among women with the metabolic syndrome (P =.02).Conclusion The metabolic syndrome was prevalent among postmenopausal women with coronary disease enrolled in the WAVE trial. Having the metabolic syndrome was not independently associated with changes in minimum lumen diameter or the development of new or progressing coronary lesions, but did confer an increased risk of clinical cardiovascular events.
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In the WAVE trial, women with MS experienced significantly more cardiac events.
“However, women in the WAVE trial with the MS did experience significantly more cardiac events.”
From Diabetes, the Metabolic Syndrome, and Angiographic Progression of Coronary Arterial Disease in Postmenopausal Women (2006) · cites this paper as [28]
In the WAVE trial, the presence of MS was not significantly associated with angiographic progression in postmenopausal women with coronary artery disease.
“Conversely, in the Women's Angiographic Vitamin and Estrogen trial (WAVE), an angiographic study involving a cohort of postmenopausal women with coronary artery disease, the presence of the MS was not significantly associated with angiographic progression.28”
From Diabetes, the Metabolic Syndrome, and Angiographic Progression of Coronary Arterial Disease in Postmenopausal Women (2006) · cites this paper as [28]
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- Authors
- Hsia, J., Bittner, V., Tripputi, M., & Howard, B. V.
- Affiliations
- George Washington University (US)
- University of Alabama at Birmingham (US)
- MedStar Health Research Institute (US)
- Corresponding author
- Hsia, Judith
- Venue
- American Heart Journal
- Publisher
- Elsevier BV
- Published
- 2003-09
- Volume
- 146
- Issue
- 3
- Pages
- 439-445
- ISSN
- 0002-8703 (ISSN-L)
- OpenAlex
- W2065227060
- Cited by
- 43
- References
- 20
- Citations by year
- 2026: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 1
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hv068170-006, n01hv068169-012, n01hv068165-011, n01hv068166-006, n01hv068168-012, n01hv068167-005)
- National Heart, Lung, and Blood Institute (N01-HV-68165, N01-HV68169, N01-HV-68166, N01-HV-68168, N01-HV-68167, N01-HV-68170)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- metabolic syndrome, postmenopausal women, coronary artery disease, minimal lumen diameter, hormone therapy, antioxidant vitamins
- MeSH terms
- Aged, Anticholesteremic Agents, Coronary Disease, Female, Humans, Middle Aged, Regression Analysis, Multivariate Analysis, Coronary Angiography, Postmenopause, Disease Progression, Metabolic Syndrome
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