Low-density lipoprotein particle size, triglycerides, and high-density lipoprotein cholesterol as risk factors for coronary heart disease in older Japanese-American men

Austin, Melissa A; Rodriguez, Beatriz L; McKnight, Barbara; McNeely, Marguerite J; Edwards, Karen L; Curb, J.David; Sharp, Dan S

doi:10.1016/s0002-9149(00)00956-5

Cited by 129Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsLipid metabolism and disorders

Low-density lipoprotein particle size, triglycerides, and high-density lipoprotein cholesterol as risk factors for coronary heart disease in older Japanese-American men

Austin, Melissa A, Rodriguez, Beatriz L, McKnight, Barbara, McNeely, Marguerite J, Edwards, Karen L, Curb, J.David, Sharp, Dan S·2000·The American Journal of Cardiology

DOI 10.1016/s0002-9149(00)00956-5

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Abstract

Decreased low-density lipoprotein (LDL) particle size is associated with coronary heart disease (CHD) risk among middle-aged Caucasian populations, and has been consistently correlated with increased plasma levels of triglyceride and decreased levels of high-density lipoprotein (HDL) cholesterol. This study examines whether these risk factors predict CHD among older Japanese-American men. With use of the Honolulu Heart Program Lipoprotein Exam 3 (1980 to 1982) as baseline, and 12-year follow-up for CHD events, a nested, case-control study was designed. One hundred forty-five incident CHD cases were identified and matched to 2 controls each. LDL particle diameter (size) was determined by gradient gel electrophoresis. A 10-angstrom (A) decrease in LDL size at baseline was associated with increased risk of incident CHD (relative risk 1.28, 95% confidence interval 1.01 to 1.63). After adjustment for baseline risk factors, the LDL size association was no longer statistically significant (relative risk 1.13, 95% confidence interval 0.86 to 1.49). When principal components analysis was used to define a composite variable for LDL size, triglycerides, and HDL cholesterol, this component predicted CHD independent of smoking, alcohol consumption, physical activity, body mass index, hypertension, diabetes, and beta-blocker use (p <0.01). Therefore, this prospective analysis of data from older, Japanese-American men demonstrated that decreased LDL size is a univariate predictor of incident CHD, and that a composite risk factor of LDL size, triglyceride, and HDL cholesterol was a risk factor for CHD independent of other risk factors.

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Authors: Austin, M. A., Rodriguez, B. L., McKnight, B., McNeely, M. J., Edwards, K. L., Curb, J. D., & Sharp, D. S.
Affiliations: University of Washington (US)
University of Hawaiʻi at Mānoa (US)
National Institutes of Health (US)
ORCID: Austin, Melissa A
Edwards, Karen L
Venue: The American Journal of Cardiology
Publisher: Elsevier BV
Published: 2000-08
Volume: 86
Issue: 4
Pages: 412-416
ISSN: 0002-9149 (ISSN-L)
DOI: 10.1016/s0002-9149(00)00956-5
OpenAlex: W1975051427
Cited by: 129
References: 31
Citations by year: 2024: 3 · 2023: 4 · 2022: 2 · 2021: 2 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 5 · 2012: 6
FWCI: 7.91
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The American Journal of Cardiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01hl050268-09)
National Heart, Lung, and Blood Institute (R01 HL50268)
National Cancer Institute (R01CA149051)
Topics: Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: triglycerides, HDL cholesterol, coronary artery disease, cardiovascular risk factors, Japanese-American men, older men, Honolulu Heart Program, incident coronary heart disease, lipoprotein metabolism
MeSH terms: Aged, Asian, Coronary Disease, Hawaii, Humans, Japan, Cholesterol, HDL, Lipoproteins, LDL, Male, Middle Aged, Particle Size, Prospective Studies, Risk Factors, Smoking, Triglycerides, Logistic Models, Case-Control Studies, Electrophoresis, Gel, Pulsed-Field

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Low-density lipoprotein particle size, triglycerides, and high-density lipoprotein cholesterol as risk factors for coronary heart disease in older Japanese-American men

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