Usefulness of corticosteroid therapy in decreasing epinephrine requirements in critically ill infants with congenital heart disease
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The use of glucocorticoids for catecholamine-resistant shock in the neonatal and pediatric population may be of benefit, including following cardiac surgery.
“The use of glucocorticoids for catecholamine-resistant shock in the neonatal and pediatric population is another strategy that may be of benefit, including following cardiac surgery [19-21].”
From Management of the Low Cardiac Output Syndrome Following Surgery for Congenital Heart Disease (2016) · cites this paper as [20]
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Early Use of Polymyxin B Hemoperfusion in Abdominal Septic Shock
Cruz, D. N., Antonelli, M. M., Fumagalli, R., Foltran, F., Brienza, N., Donati, A., Malcangi, V., Petrini, F., Volta, G., Pallavicini, F. M. B., et al. (2009) · JAMA · doi:10.1001/jama.2009.856 · Cited by 841 · see citing works
Cheung, M., Kharbanda, R., Konstantinov, I., Shimizu, M., Frndova, H., Li, J., Holtby, H., Cox, P., Smallhorn, J., Arsdell, G. V., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.01.066 · Cited by 572 · see citing works
Joannès-Boyau, O., Honoré, P. M., Perez, P., Bagshaw, S. M., Grand, H., Canivet, J.-L., Dewitte, A., Flamens, C., Pujol, W., Grandoulier, A. A., et al. (2013) · Intensive Care Medicine · doi:10.1007/s00134-013-2967-z · Cited by 423 · see citing works
“The dosages of vasoactive/vasopressor agents were expressed as the inotropic score [36, 37], a dimensionless variable calculated as (dopamine dosage 9 1) ? (dobutamine dosage 9 1) ? (adrenaline dosage 9 100) ? (noradrenaline dosage 9 100), wherein all dosages are expressed as micrograms per kilogram per minute.”
BackgroundDent, C., Spaeth, J., Jones, B., Schwartz, S. M., Glauser, T., Hallinan, B., Pearl, J., Khoury, P., & Kurth, C. (2005) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2005.07.051 · Cited by 194 · see citing works
“1524 The Journal of Thoracic and Cardiovascular Surgery ● Dec overall status, a preoperative inotropic score was calculated as the sum of all inotrope doses, correcting for potency.(15,16) Preoperative”
MethodSelf-citationRetractedCardiopulmonary Resuscitation in Infants and Children With Cardiac Disease
Marino, B. S., Tabbutt, S., MacLaren, G., Hazinski, M. F., Adatia, I., Atkins, D. L., Checchia, P. A., DeCaen, A., Fink, E. L., Hoffman, G. M., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000524 · Cited by 204 · see citing works
Dent, C., Spaeth, J., Jones, B., Schwartz, S. M., Glauser, T., Hallinan, B., Pearl, J., Khoury, P., & Kurth, C. (2005) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2005.10.003 · Cited by 154 · see citing works
Self-citationRetractedSchroeder, V. A., Pearl, J. M., Schwartz, S., Shanley, T., Manning, P., & Nelson, D. (2003) · Circulation · doi:10.1161/01.cir.0000070955.55636.25 · Cited by 146 · see citing works
Self-citationGastrointestinal morbidity after Norwood palliation for hypoplastic left heart syndrome.
Jeffries, H., Wells, W., Starnes, V., Wetzel, R., & Moromisato, D. (2006) · Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2005.09.001 · Cited by 133
Li, L., Luo, W., Huang, L.-J., Zhang, W., Gao, Y., Jiang, H., Zhang, C.-F., Long, L., & Chen, S.-X. (2010) · Journal of Surgical Research · doi:10.1016/j.jss.2010.06.016 · Cited by 113
“The first postoperative 24 h quantitative measures of inotropes were evaluated by inotropic score with the formula: ([dopamineþ dobutamine] 3 1)þ (milrinone 3 15)þ ([epinephrine þ norepinephrine þ isoproterenol] 3 100) [15].”
MethodEffect of ischemic postconditioning in adult valve replacement.
Luo, W., Li, B., Chen, R., Huang, R., & Lin, G.-Q. (2008) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/j.ejcts.2007.11.010 · Cited by 107
“The first postoperative 24 h quantitative measures of inotropes were evaluated by inotropic score with the formula [8]: ([dopamine + dobutamine]”
Ricci, Z., Luciano, R., Favia, I., Garisto, C., Muraca, M., Morelli, S., di Chiara, L., Cogo, P., & Picardo, S. (2011) · Critical Care · doi:10.1186/cc10295 · Cited by 103 · see citing works
Steroid supplementation: a legitimate pharmacotherapy after neonatal open heart surgery.
Ando, M., Park, I.-S., Wada, N., & Takahashi, Y. (2005) · Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2005.04.035 · Cited by 97
Acute renal failure in children undergoing cardiopulmonary bypass.
Skippen, P. W., & Krahn, G. (2005) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)02017-3 · Cited by 93 · see citing works
Burkhardt, B. E., Rücker, G., & Stiller, B. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009515.pub2 · Cited by 81 · see citing works
Yang, L.-F., Yang, J., Wang, Q., Chen, M., Lu, Z.-H., Chen, S.-Y., & Xiong, L. (2010) · Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2009.12.003 · Cited by 77
Bonacchi, M., Spina, R., Torracchi, L., Harmelin, G., Sani, G., & Peris, A. (2013) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2012.08.046 · Cited by 76
Management of the Low Cardiac Output Syndrome Following Surgery for Congenital Heart Disease
K. Chandler, H., & Kirsch, R. (2016) · Current Cardiology Reviews · doi:10.2174/1573403x12666151119164647 · Cited by 74 · see citing works
“The use of glucocorticoids for catecholamine-resistant shock in the neonatal and pediatric population is another strategy that may be of benefit, including following cardiac surgery [19-21].”
BackgroundProcalcitonin and C-reactive protein kinetics in postoperative pediatric cardiac surgical patients.
Arkader, R., Troster, E., Abellan, D. M., Lopes, M., Raiz, R., Carcillo, J., & Okay, T. (2004) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2004.01.021 · Cited by 72
Suominen, P. K., Dickerson, H. A., Moffett, B. S., Ranta, S. O., Mott, A. R., Price, J. F., Heinle, J. S., McKenzie, E. D., Fraser, C. D., & Chang, A. C. (2005) · Pediatric Critical Care Medicine · doi:10.1097/01.pcc.0000185487.69215.29 · Cited by 67 · see citing works
“In 2001, investigators reported that low-dose hydrocortisone significantly reduced inotropic requirements in children with congenital heart disease (3).”
BackgroundMethodResultInfluentialSrisawat, N., Tungsanga, S., Lumlertgul, N., Komaenthammasophon, C., Peerapornratana, S., Thamrongsat, N., Tiranathanagul, K., Praditpornsilpa, K., Eiam‐Ong, S., Tungsanga, K., et al. (2018) · Critical Care · doi:10.1186/s13054-018-2077-y · Cited by 95 · see citing works
Humphreys, N., Bays, S., Parry, A., Pawade, A., Heyderman, R., & Wolf, A. (2005) · Anesthesiology · doi:10.1097/00000542-200512000-00003 · Cited by 59
Robert, S. M., Borasino, S., Dabal, R., Cleveland, D., Hock, K. M., & Alten, J. (2015) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000000426 · Cited by 57 · see citing works
Li, Y., Dong, H., Chen, M., Liu, J.-C., Yang, L.-F., Chen, S.-Y., & Xiong, L. (2011) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2011.06.017 · Cited by 57
Gut permeability in paediatric cardiac surgery.
Malagon, I., Onkenhout, W., Klok, G., van der Poel, P. V. D., Bovill, J. G., & Hazekamp, M. (2005) · British Journal of Anaesthesia · doi:10.1093/bja/aei014 · Cited by 57 · see citing works
Management of the postoperative pediatric cardiac surgical patient
Bronicki, R. A., & Chang, A. C. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e31821b82a6 · Cited by 55 · see citing works
McNally, J. D., Menon, K., Chakraborty, P. K., Fisher, L., Williams, K., Al-Dirbashi, O. Y., Girolamo, T., Maharajh, G., & Doherty, D. R. (2013) · Anesthesiology · doi:10.1097/aln.0b013e31828ce817 · Cited by 60 · see citing works
Malagon, I., Hogenbirk, K., van Pelt, J., Hazekamp, M., & Bovill, J. G. (2005) · British Journal of Anaesthesia · doi:10.1093/bja/aei142 · Cited by 51
Yeh, Y., Lee, C.-T., Wang, C.-H., Tu, Y.-K., Lai, C., Wang, Y.-C., Chao, A., Huang, C.-H., Cheng, Y., & Chen, Y.-S. (2018) · Critical Care · doi:10.1186/s13054-018-2081-2 · Cited by 50
Gajarski, R., Stefanelli, C. B., Graziano, J. N., Kaciroti, N., Charpie, J., & Vazquez, D. (2010) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e3181a64743 · Cited by 49 · see citing works
“Refractory hypotension has been noted in neonates undergoing cardiac repair, and previous investigators have cited improvement in blood pressure with decreased vasopressor use following steroid treatment in a subset of these infants (15, 16).”
BackgroundFenoldopam in newborn patients undergoing cardiopulmonary bypass: controlled clinical trial.
Ricci, Z., Stazi, G., di Chiara, L., Morelli, S., Vitale, V., Giorni, C., Ronco, C., & Picardo, S. (2008) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1510/icvts.2008.185025 · Cited by 48
Postconditioning the human heart with adenosine in heart valve replacement surgery.
Jin, Z.-X., Zhou, J.-J., Xin, M., Peng, D., Wang, X.-M., Bi, S., Wei, X.-F., & Yi, D. (2007) · Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2006.12.031 · Cited by 48
Cheung, M. M. H., Smallhorn, J. F., Vogel, M., Arsdell, G. V., & Redington, A. N. (2006) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2005.09.056 · Cited by 49 · see citing works
“Postoperatively, patients were studied at 3, 6, 12, and 24 hours, provided the patients remained intubated, sedated, and ventilated.”
BackgroundMultiorgan protection of remote ischemic perconditioning in valve replacement surgery.
Hu, Q.-H., Luo, W., Huang, L.-J., Huang, R., Chen, R., & Gao, Y. (2016) · Journal of Surgical Research · doi:10.1016/j.jss.2015.06.053 · Cited by 41
“[15] Shore S, Nelson DP, Pearl JM, et al.”
BackgroundMethodGlucocorticoid Therapy for Hypotension in the Cardiac Intensive Care Unit
Millar, K. J., Thiagarajan, R., & Laussen, P. (2007) · Pediatric Cardiology · doi:10.1007/s00246-006-0053-9 · Cited by 38 · see citing works
“We therefore chose 12 hours before and 24 hours after glucocorticoid administration, although there are reports of dramatic responses to steroid treatment within 12 hours [30].”
BackgroundMethodHamilton, B., Honjo, O., Alghamdi, A., Caldarone, C., Schwartz, S., Arsdell, G. V., & Holtby, H. (2014) · Seminars in Cardiothoracic and Vascular Anesthesia · doi:10.1177/1089253213519291 · Cited by 35 · see citing works
“A version of the Vasoactive-Inotrope Score was used to calculate postoperative use of inotropes as follows: 1 × dopamine dose (μg/ kg/min) + 15 × milrinone dose (μg/kg/min) + 100 × epinephrine dose (μg/kg/min) + 100 × norepinephrine dose (μg/kg/min).(8-10) Repeated variables were assessed every 8 hours for 48 hours po…”
MethodSelf-citationThe effect of cardiopulmonary bypass on the hypothalamic-pituitary-adrenal axis in children*
Wald, E. L., Preze, E., Eickhoff, J., & Backer, C. (2011) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e3181f36d17 · Cited by 35 · see citing works
“Two pediatric studies have shown that there may be a benefit to postoperative glucocorticoid supplementation after congenital heart surgery, noting improved left ventricular shortening fraction, decreased inotrope scores, as well as trends toward decreased fluid requirements, improved oxygenation, and decreased ventil…”
BackgroundNeonatal cardiac care, a perspective.
Krishnamurthy, G., Ratner, V., & Bacha, E. (2013) · Seminars in Thoracic and Cardiovascular Surgery Pediatric Cardiac Surgery Annual · doi:10.1053/j.pcsu.2013.01.007 · Cited by 35 · see citing works
Jin, Z.-X., Zhang, S.-L., Wang, X.-M., Bi, S., Xin, M., Zhou, J.-J., Cui, Q., Duan, W., Wang, H.-B., & Yi, D. (2008) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2008.03.025 · Cited by 32
Chang, A., & McKenzie, E. D. (2004) · Pediatric Cardiology · doi:10.1007/s00246-004-0715-4 · Cited by 35 · see citing works
Effect of morphine-induced postconditioning in corrections of tetralogy of fallot
Zhang, R.-F., Shen, L., Xie, Y., Gen, L., Li, X., & Ji, Q. (2013) · Journal of Cardiothoracic Surgery · doi:10.1186/1749-8090-8-76 · Cited by 28
“The first postoperative 24-hour quantitative measures of inotropes were evaluated by the inotropic score according to the following formula [22]:”
MethodBottiroli, M., Monti, G., Pinciroli, R., Vecchi, I., Terzi, V., Ortisi, G., Casella, G., & Fumagalli, R. (2017) · Journal of critical care · doi:10.1016/j.jcrc.2017.04.030 · Cited by 25
“The need for vasoactive support was measured as “inotropic score” [11,12]: (dopamine dose × 1) + (dobutamine dose × 1) + (adrenaline dose × 100) + (noradrenaline dose × 100) + (phenylephrine dose × 100), wherein agents' doses are expressed as μg/kg/min.”
BackgroundLim, H. S. (2016) · European heart journal. Acute cardiovascular care · doi:10.1177/2048872615610865 · Cited by 24
“5(7) 82 –88 © The European Society of Cardiology 2015 Reprints and permissions: sagepub.”
BackgroundInfluentialManuri, L., Morelli, S., Agati, S., Saitta, M. B., Oreto, L., Mandraffino, G., Iannace, E., Iorio, F., & Guccione, P. (2016) · Cardiology in the Young · doi:10.1017/s1047951116000275 · Cited by 24
Póvoa, P. M. S. R., Salluh, J. I., Martínez, M. L., Guillamat‐Prats, R., Gallup, D. S., Al‐Khalidi, H. R., Thompson, B., Ranieri, V. M., & Artigas, A. (2015) · Critical Care · doi:10.1186/s13054-015-0921-x · Cited by 23 · see citing works
“(mcg/kg/min) × 1) + (epinephrine dose (mcg/kg/min) × 100) + (norepinephrine dose (mcg/kg/min) × 100) + (phenylephrine dose (mcg/kg/min) × 100 + (vasopressin dose (mcg/ kg/min) × 100) [20-22]; whether or not the patient had an abdominal infection, and whether or not the patient had a lung infection.”
BackgroundInotropic support and peritoneal dialysis adequacy in neonates after cardiac surgery.
Ricci, Z., Morelli, S., Ronco, C., Polito, A., Stazi, G., Giorni, C., di Chiara, L., & Picardo, S. (2008) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1510/icvts.2007.165118 · Cited by 23
Hemodynamic correlates of serum cortisol in neonates after cardiopulmonary bypass*
Mackie, A., Gauvreau, K., Booth, K., Newburger, J., Laussen, P., & Roth, S. (2011) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0b013e3181f36929 · Cited by 19
“When administered following CPB, three small, uncontrolled studies have suggested a benefit from corticosteroids, including an increase in blood pressure (BP) and a reduction of inotrope requirements among neonates (6) and young children (2, 7) with refractory hypotension on high-dose epinephrine.”
BackgroundInfluentialPostoperative management: The role of mixed venous oxygen saturation monitoring
Bradley, S. M., & Atz, A. M. (2005) · Seminars in Thoracic and Cardiovascular Surgery Pediatric Cardiac Surgery Annual · doi:10.1053/j.pcsu.2005.01.002 · Cited by 22 · see citing works
Stuth, E., Berens, R., Staudt, S. R., Robertson, F. A., Scott, J., Stucke, A., Hoffman, G., Troshynski, T. J., Tweddell, J., & Zuperku, E. (2011) · Paediatric anaesthesia · doi:10.1111/j.1460-9592.2011.03527.x · Cited by 18
Kumar, G., & Iyer, P. (2010) · Annals of Pediatric Cardiology · doi:10.4103/0974-2069.74045 · Cited by 18 · see citing works
“[45] In a retrospective study of critically ill postoperative cardiac neonates, low dose corticosteroids reduced the epinephrine requirement as well as the inotrope score within 24 hours.[46] We administer hydrocortisone 50 mg/m2/day to sick neonates and infants with LCOS.”
BackgroundBaek, S. D., Yu, H., Shin, S., Park, H.-S., Kim, M.-S., Kim, S. M., Lee, E. K., & Chang, J. W. (2016) · Journal of Critical Care · doi:10.1016/j.jcrc.2016.12.014 · Cited by 15 · see citing works
“The inotropic score was calculated as follows [19]: (dopamine dose × 1) + (dobutamine dose × 1) + (adrenaline dose × 100) + (noradrenaline × 100) + (phenylephrine dose × 100).”
Impacts of intensive insulin therapy in patients undergoing heart valve replacement.
Zheng, R.-H., Gu, C., Wang, Y.-Y., Yang, Z.-Y., Dou, K., Wang, J., Yu, S.-Q., Wang, H.-B., Xie, J., Wang, Y.-M., et al. (2010) · Heart Surgery Forum · doi:10.1532/hsf98.20101017 · Cited by 17
Burkhardt, B. E. U., Hummel, J., Rücker, G., & Stiller, B. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013707 · Cited by 4 · see citing works
Verweij, E. J., Hogenbirk, K., Roest, A. A. W., van Brempt, R., Hazekamp, M. G., & de Jonge, E. (2012) · Interactive CardioVascular and Thoracic Surgery · doi:10.1093/icvts/ivs292 · Cited by 16 · see citing works
“hydrocortisone administration may improve haemodynamic stability in case of resistant LCOS in children and adults [1, 3, 5–10, 14, 15].”
BackgroundDirect hemoperfusion with polymyxin B immobilized fiber for abdominal sepsis in Europe
Sato, K., Maekawa, H., Sakurada, M., Orita, H., & Komatsu, Y. (2011) · Surgery today (Print) · doi:10.1007/s00595-010-4504-9 · Cited by 16
“The dose of vasoactive/vasopressor agents was expressed as the inotropic score.(52,53) This score has also been referred to as the vasopressor score(54) or catecholamine index.”
"Early" delayed sternal closure following pediatric cardiac surgery.
Riphagen, S., McDougall, M., Tibby, S., Alphonso, N., Anderson, D., Austin, C., Durward, A., & Murdoch, I. (2005) · Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2005.02.040 · Cited by 16 · see citing works
WITHDRAWN: Prophylactic steroids for pediatric open heart surgery.
Elbarbary, M., Madani, W., & Robertson-Malt, S. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005550.pub3 · Cited by 14
Adrenocortical function in the postoperative pediatric cardiac surgical patient
Green, M. L., & Koch, J. (2012) · Current opinion in pediatrics · doi:10.1097/mop.0b013e3283532d12 · Cited by 14 · see citing works
“[34] retrospectively reviewed 21 infants and children on highdose epinephrine, 10 of whom were treated with corticosteroids.”
BackgroundPostoperative Care of the Pediatric Cardiac Surgical Patient
Krawczeski, C. D., & Schwartz, S. M. (2008) · Springer eBooks · doi:10.1007/978-1-84800-923-3_16 · Cited by 10 · see citing works
“Supplementation with corticosteroids in particular has shown some promise in treating refractory hypotension [ 63 ].”
BackgroundSelf-citationEffects of polymyxin B hemoperfusion on hemodynamics and prognosis in septic shock patients
Lee, C.-T., Tu, Y.-K., Yeh, Y.-C., Chang, T., Shih, P., Chao, A., Huang, H.-H., Cheng, Y., & Yeh, Y. (2018) · Journal of critical care · doi:10.1016/j.jcrc.2017.04.035 · Cited by 13
Ding, W.-J., Ji, Q., Wei, Q., Shi, Y.-Q., Ma, R.-H., & Wang, C.-S. (2015) · The Cardiology · doi:10.1159/000377720 · Cited by 13
Sasser, W. C., Robert, S. M., Carlo, W. F., Borasino, S., Dabal, R., Kirklin, J., & Alten, J. (2012) · World journal for pediatric & congenital heart surgery · doi:10.1177/2150135111431268 · Cited by 13 · see citing works
“Much of the support for CIRCI as a contributor to LCOS after congenital heart surgery originates from small clinical studies that demonstrate benefit of exogenous steroid supplementation on various short-term clinical and laboratory outcomes (ie, decreased inotrope requirements, decreased fluid requirements, improved…”
BackgroundKrishnamurthy, G. (2019) · Seminars in Thoracic and Cardiovascular Surgery Pediatric Cardiac Surgery Annual · doi:10.1053/j.pcsu.2019.02.009 · Cited by 13 · see citing works
Adrenal insufficiency in hemodynamically unstable neonates after open-heart surgery.
Garcia, X., Bhutta, A., Dyamenahalli, U., Imamura, M., Jaquiss, R., & Prodhan, P. (2010) · Congenital Heart Disease · doi:10.1111/j.1747-0803.2010.00447.x · Cited by 12 · see citing works
Wei, T., Wang, C.-H., Chan, W.-S., Huang, C.-H., Lai, C., Wang, M.-J., Chen, Y.-S., Ince, C., Lin, T.-Y., & Yeh, Y. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.649263 · Cited by 11
“The inotropic score was calculated as 100 × epinephrine dose (mcg/kg/min) + 100 × norepinephrine dose (mcg/kg/min) + dopamine dose (mcg/kg/min) + dobutamine dose (mcg/kg/min) (18).”
MethodPediatric Cardiac Intensive Care Society 2014 Consensus Statement
Soto-Rivera, C. L., Agus, M. S. D., Sawyer, J. E., & Macrae, D. J. (2016) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000000625 · Cited by 13 · see citing works
“Retrospective analyses have shown a positive hemodynamic response to steroids (75, 76) which in some series has been associated with improved survival (75).”
BackgroundHeart Failure Treatment in the Intensive Care Unit in Children
Jefferies, J. L., Hoffman, T. M., & Nelson, D. P. (2010) · Heart Failure Clinics · doi:10.1016/j.hfc.2010.06.001 · Cited by 15 · see citing works
Self-citationGaristo, C., Favia, I., Ricci, Z., Chiara, L. D., Morelli, S., Giorni, C., Vitale, V., Picardo, S. G., & Donato, R. M. D. (2010) · World Journal for Pediatric and Congenital Heart Surgery · doi:10.1177/2150135110378310 · Cited by 9 · see citing works
“A few age-related myocyte histopathologic features might explain this poor contractile efficiency: (1) decreased sympathetic innervation on downregulated and insensitive adrenergic receptors, (2) immaturity of the dyads with impaired mechanism of calcium-induced calcium release, (3) poor control of intracytosolic calc…”
BackgroundRETRACTED: Dexamethasone reduces gut permeability in pediatric cardiac surgery
Malagon, I., Onkenhout, W., Klok, M., Linthorst, L., van der Poel, P. F. H., Bovill, J., & Hazekamp, M. (2005) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2005.02.047 · Cited by 11 · see citing works
RetractedBaek, S. D., Kang, J.-Y., Shin, S., Park, H.-S., Kim, M.-S., Kim, S. M., Lee, E. K., & Chang, J. W. (2019) · Shock · doi:10.1097/shk.0000000000001328 · Cited by 10 · see citing works
“The inotropic score was calculated the same as in a previous study (13): (dopamine dose 1)þ (dobutamine dose 1) þ (adrenaline dose 100) þ (noradrenaline 100) þ (phenylephrine dose 100).”
MethodWald, E. L., Backer, C., Dearani, J., Li, Z., Oliver, W. C., & Crow, S. S. (2017) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2016.11.030 · Cited by 10 · see citing works
Schiller, O., Dagan, O., Birk, E., Bitan, S., Amir, G., Frenkel, G., & Nahum, E. (2013) · Pediatric Cardiology · doi:10.1007/s00246-013-0728-y · Cited by 10
Prophylactic steroids for paediatric open‐heart surgery: a systematic review
Robertson-Malt, S., & Barbary, M. E. E. (2008) · International Journal of Evidence-Based Healthcare · doi:10.1111/j.1744-1609.2008.00112.x · Cited by 10
Cheng, C.-F., Chen, Y.-Y., Shih, M.-C., Huang, Y.-M., Tseng, L.-J., Lai, C., Lan, T.-Y., Lu, C.-H., Hsieh, S.-C., Li, K.-J., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.755147 · Cited by 9 · see citing works
“The inotropic score was calculated as 100 × epinephrine dose (μg/kg/min) + 100 × norepinephrine dose (μg/kg/min) + dopamine dose (μg/kg/min)+ dobutamine dose (μg/kg/min) (23).”
MethodExtracorporeal life support in polytraumatized patients.
Bonacchi, M. (2016) · International Journal of Surgery · doi:10.1016/j.ijsu.2015.11.001 · Cited by 9
“If cardiopulmonary resuscitation was performed befo re ECLS and brain injury was suspected the integrated heater exchanger allows for therapeutic hypothermia for 48-72 hours to reduce brain lesions [18, 19, 24-26].”
MethodSteroids Improve Hemodynamics in Infants With Adrenal Insufficiency After Cardiac Surgery.
Maeda, T., Takeuchi, M., Tachibana, K., Nishida, T., Kagisaki, K., & Imanaka, H. (2016) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2015.11.025 · Cited by 9 · see citing works
Advances in cardiac intensive care
Cooper, D., & Nichter, M. (2006) · Current opinion in pediatrics · doi:10.1097/01.mop.0000245350.30089.69 · Cited by 9 · see citing works
Steroids for Adult and Pediatric Cardiac Surgery: A Clinical Update.
Crawford, J., & Townsley, M. M. (2018) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2018.11.023 · Cited by 8 · see citing works
Suominen, P., Keski-Nisula, J., Tynkkynen, P., Kantoluoto, S., Olkkola, K., & Mildh, L. (2012) · Perfusion · doi:10.1177/0267659112442237 · Cited by 8
First nights, the adrenal axis, and steroids
Graham, E., & Bradley, S. (2017) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2016.12.013 · Cited by 7
“In patients with postoperative catecholamine-res istant hypotension, rescue steroid therapy 115 can be effective, regardless of cortisol levels (18 ,19).”
BackgroundMatsukuma, S., Sakamoto, K., Nishiyama, M., Tamesa, T., Yoshino, S., Hazama, S., Oshibuchi, R., Matsuda, N., Matsumoto, S., Wakamatsu, H., et al. (2015) · Journal of Intensive Care · doi:10.1186/s40560-015-0078-3 · Cited by 7
“The inotropic score [21,22] is the most commonly used index in critical care medicine for expressing hemodynamic dysfunction and is calculated as follows (all doses are expressed as μg/kg/min): (dopamine dose × 1) + (dobutamine dose × 1) + (adrenaline dose × 100) + (noradrenaline dose × 100) + (phenylephrine dose × 10…”
MethodJi, Q., Ding, W., Mei, Y., Wang, X., Feng, J., & Cai, J. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.05.020 · Cited by 7 · see citing works
Extracorporeal membrane oxygenation for treatment of cardiac failure in adult patients.
Luo, X.-J., Wang, W., Hu, S.-S., Sun, H.-S., Gao, H.-W., Long, C., Song, Y.-H., & Xu, J.-P. (2009) · Interactive Cardiovascular and Thoracic Surgery · doi:10.1510/icvts.2008.197681 · Cited by 7
Ando, M., Takahashi, Y., & Kikuchi, T. (2005) · Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2005.02.087 · Cited by 7
“The indexed catecholamine dose was alculated as dopamine ( 1) epinephrine ( 100) [6].”
MethodTanaka, Y., Okano, K., Tsuchiya, K., Yamamoto, M., & Nitta, K. (2016) · doi:10.21767/2472-5056.100004 · Cited by 7
“The inotropic score calculated as follows [11-12].”
Baek, S. D., Kang, J.-Y., Yu, H., Shin, S., Park, H.-S., Kim, M.-S., Lee, E. K., Kim, S. M., & Chang, J. (2018) · BMC Nephrology · doi:10.1186/s12882-018-1028-9 · Cited by 6
Neunhoeffer, F., Renk, H., Hofbeck, M., Grenz, C., Haller, C., Heimberg, E., Gerbig, I., Schlensak, C., & Kumpf, M. (2015) · Pediatric Cardiology · doi:10.1007/s00246-014-1059-3 · Cited by 6 · see citing works
“However, the mechanisms of this vasoactive effect remain unclear and absence of vascular response to hydrocortisone does not necessarily imply an inadequate adrenal response [24, 28].”
BackgroundInfluentialBenken, S. T., Hutson, T., Gardiner, R. L., & Wheeler, D. (2010) · Open Critical Care Medicine Journal · doi:10.2174/1874828701003010051 · Cited by 6
“In addition, we excluded those children who received CRT following cardiopulmonary bypass for repair or palliation of congenital heart disease [15, 16].”
Rossano, J., & Chang, A. C. (2006) · Cardiology in the Young · doi:10.1017/s1047951105002325 · Cited by 6 · see citing works
Lee, C.-T., Wang, C.-H., Chan, W.-S., Tsai, Y.-Y., Wei, T., Lai, C., Wang, M.-J., Chen, Y.-S., & Yeh, Y. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.772413 · Cited by 4
“The inotropic score (IE) was calculated at the four time points as 100 × epinephrine dose (μg/kg/min) + 100 × norepinephrine dose (μg/kg/min)+ dopamine dose (μg/kg/min)+ dobutamine dose (μg/kg/min) (12).”
MethodYou, J.-O., Lim, J. Y., & Jung, S.-H. (2018) · The Korean journal of thoracic and cardiovascular surgery · doi:10.5090/kjtcs.2018.51.2.109 · Cited by 4 · see citing works
“Several studies reported hydrocortisone administration to be effective in cases of persistent LCOS, mostly in pediatric patients [2,14-18].”
BackgroundGeorgiev, S., Latcheva, A. Z., Pilossoff, V., Lazarov, S. D., & Mitev, P. (2012) · World journal for pediatric & congenital heart surgery · doi:10.1177/2150135111424294 · Cited by 4
“13 Aortic cross clamp time (min) (INTRA) 30 (4-87) 20 (0-87) .”
Sahulee, R., & McKinstry, J. (2022) · Vessel Plus · doi:10.20517/2574-1209.2021.94 · Cited by 2 · see citing works
Lee, J. M., Baek, S. D., Kim, T. H., Jeon, H. R., Han, J., & Chang, J. W. (2021) · Shock · doi:10.1097/shk.0000000000001752 · Cited by 5 · see citing works
“, need for RRT) for more than 4 weeks Inotropic score was calculated as follows (21): (dopamine dose 1) þ (dobutamine dose 1) þ (adrenaline dose 100) þ (noradrenaline dose 100)þ (phenylephrine dose 100).”
MethodClinical significance of serum cortisol levels following surgery for congenital heart disease
Teagarden, A. M., & Mastropietro, C. (2016) · Cardiology in the Young · doi:10.1017/s104795111600055x · Cited by 3 · see citing works
Endocrinopathies in the Cardiac ICU
Schwartz, S., Anand, K., Portman, M., Crow, S. S., Nelson, D., & Zimmerman, J. (2011) · World journal for pediatric & congenital heart surgery · doi:10.1177/2150135111406941 · Cited by 3 · see citing works
“The smaller pediatric studies looking specifically at postoperative hydrocortisone found no significant difference in blood glucose levels before and after hydrocortisone initiation or between the hydrocortisone and placebo groups.(107,108,110) The large pediatric cohort in the Pasquali et al study had higher frequenc…”
BackgroundSelf-citationCritical Illness-Related Corticosteroid Insufficiency (CIRCI) After Pediatric Cardiac Surgery
Ahmed, A., Kesman, R. A., & Lee, M. E. (2024) · World journal for pediatric & congenital heart surgery · doi:10.1177/21501351231221455 · Cited by 2
“3,10,21 Short-Term and Long-Term Implications of Corticosteroid Use The short-and medium-term implications of corticosteroids after congenital heart surgery continue to be fi ercely debated.”
BackgroundPark, Y. J., & Kim, E. Y. (2020) · doi:10.17479/jacs.2020.10.1.13 · Cited by 2
“wherein all doses are expressed as μg/kg/min [10].”
Huff, C., Mastropietro, C. W., Riley, C. M., Byrnes, J. W., Kwiatkowski, D. M., Ellis, M., Schuette, J. J., & Justice, L. B. (2018) · World Journal for Pediatric and Congenital Heart Surgery · doi:10.1177/2150135118779072 · Cited by 1 · see citing works
Calcitriol trend following pediatric cardiac surgery and association with clinical outcome
Acharya, N., Doherty, D., Barrowman, N., Maharajh, G., Girolamo, T., O'Hearn, K., & McNally, J. (2018) · Pediatric Research · doi:10.1038/s41390-018-0049-1 · Cited by 2
Useful References in Pediatric Cardiac Intensive Care: The 2017 Update*
Uzark, K. C., Costello, J. M., DeSena, H. C., Thiagajaran, R., Smith-Parrish, M., & Gist, K. M. (2018) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000001523 · Cited by 1 · see citing works
- Authors
- Shore, S., Nelson, D. P., Pearl, J. M., Manning, P. B., Wong, H., Shanley, T. P., Keyser, T., & Schwartz, S. M.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Schwartz, Steven M
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2001-09
- Volume
- 88
- Issue
- 5
- Pages
- 591-594
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2172221324
- Cited by
- 141
- References
- 0
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 11 · 2017: 7 · 2016: 9 · 2015: 11 · 2014: 5 · 2013: 8 · 2012: 6
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
- Keywords
- glucocorticoids, epinephrine requirement, congenital heart disease, critically ill infants, inotropic requirement, hemodynamic instability, neonatal cardiac surgery, adrenal insufficiency, stress response
- MeSH terms
- Adrenal Cortex Hormones, Dose-Response Relationship, Drug, Drug Interactions, Drug Therapy, Combination, Epinephrine, Female, Follow-Up Studies, Heart Defects, Congenital, Hemodynamics, Humans, Infant, Infant, Newborn, Intensive Care Units, Neonatal, Male, Retrospective Studies, Severity of Illness Index, Critical Illness, Treatment Outcome
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