Normal human right and left ventricular mass, systolic function, and gender differences by cine magnetic resonance imaging
Abstract
Our objective was to establish normal ranges of left and right ventricular mass and function with cine magnetic resonance imaging (MRI) and to determine gender differences. Seventy-five healthy subjects (age range 8-55, mean 28 yr) were studied with cine MRI. Ten dogs were imaged for autopsy validation with a mean difference between actual and MRI-determined mass of 0.2 A +/- 8.4 g. Intraobserver and interobserver variability and interstudy variability were 5-6%. All parameters were significantly different between males and females except ejection fraction and the left ventricular mass to end-diastolic volume ratio. Agreement with published autopsy series, including gender differences, was excellent. This study presents normative MRI data that can be used for comparing individual patients and for further study of right and left ventricular interaction.
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Women are known to have on average smaller hearts and have differences in electrophysiology, and this relationship between heart size and tissue properties may not be explicitly represented in a model.
“For example, women are known to have on average smaller hearts and have differences in electrophysiology [69, 70], and this relationship between heart size and tissue properties may not be explicitly represented in a model.”
From Credibility assessment of in silico clinical trials for medical devices (2024) · cites this paper as [69]
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Credibility assessment of in silico clinical trials for medical devices
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“For example, women are known to have on average smaller hearts and have differences in electrophysiology [69, 70], and this relationship between heart size and tissue properties may not be explicitly represented in a model.”
- Authors
- Lorenz, C., Walker, E., Morgan, V., Klein, S., & Graham, T.
- Affiliations
- Washington University Medical Center (US)
- Vanderbilt University Medical Center (US)
- Venue
- Journal of Cardiovascular Magnetic Resonance
- Published
- 1999-01-01
- Volume
- 1
- Issue
- 1
- Pages
- 7-21
- ISSN
- 1097-6647 (ISSN-L)
- OpenAlex
- W2120945511
- Semantic Scholar
- bdc7d05ecf2a043010ea073d45dac42fa15ecaff
- Cited by
- 717
- References
- 36
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 12 · 2021: 14 · 2020: 16 · 2019: 16 · 2018: 21 · 2017: 12 · 2016: 27 · 2015: 32 · 2014: 34 · 2013: 30 · 2012: 36
- FWCI
- 16.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cardiovascular Magnetic Resonance (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2s07rr005424-30)
- National Center for Research Resources (2S07-RR05424)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- left ventricular mass, right ventricular mass, systolic function, ejection fraction, reference values, gender differences, cine MRI
- MeSH terms
- Adolescent, Adult, Animals, Cardiac Volume, Child, Dogs, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Reference Values, Sex Characteristics, Systole, Observer Variation, Linear Models, Ventricular Function, Left, Ventricular Function, Right, Magnetic Resonance Imaging, Cine
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