Cited by 717Cardiovascular Function and Risk FactorsCardiac Imaging and DiagnosticsAdvanced MRI Techniques and Applications

Normal human right and left ventricular mass, systolic function, and gender differences by cine magnetic resonance imaging

Lorenz, Christine, Walker, Eloisa, Morgan, Victoria, Klein, Stacy, Graham, Thomas·1999·Journal of Cardiovascular Magnetic Resonance

Abstract

Our objective was to establish normal ranges of left and right ventricular mass and function with cine magnetic resonance imaging (MRI) and to determine gender differences. Seventy-five healthy subjects (age range 8-55, mean 28 yr) were studied with cine MRI. Ten dogs were imaged for autopsy validation with a mean difference between actual and MRI-determined mass of 0.2 A +/- 8.4 g. Intraobserver and interobserver variability and interstudy variability were 5-6%. All parameters were significantly different between males and females except ejection fraction and the left ventricular mass to end-diastolic volume ratio. Agreement with published autopsy series, including gender differences, was excellent. This study presents normative MRI data that can be used for comparing individual patients and for further study of right and left ventricular interaction.

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Crossref · 10.3109/10976649909080829

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36 of 36 references verified0 citation errors · 0 not checkable

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  • Women are known to have on average smaller hearts and have differences in electrophysiology, and this relationship between heart size and tissue properties may not be explicitly represented in a model.

    “For example, women are known to have on average smaller hearts and have differences in electrophysiology [69, 70], and this relationship between heart size and tissue properties may not be explicitly represented in a model.”

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Authors
Lorenz, C., Walker, E., Morgan, V., Klein, S., & Graham, T.
Affiliations
  • Washington University Medical Center (US)
  • Vanderbilt University Medical Center (US)
Venue
Journal of Cardiovascular Magnetic Resonance
Published
1999-01-01
Volume
1
Issue
1
Pages
7-21
ISSN
1097-6647 (ISSN-L)
OpenAlex
W2120945511
Cited by
717
References
36
Citations by year
2026: 7 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 12 · 2021: 14 · 2020: 16 · 2019: 16 · 2018: 21 · 2017: 12 · 2016: 27 · 2015: 32 · 2014: 34 · 2013: 30 · 2012: 36
FWCI
16.48
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cardiovascular Magnetic Resonance (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (2s07rr005424-30)
  • National Center for Research Resources (2S07-RR05424)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
left ventricular mass, right ventricular mass, systolic function, ejection fraction, reference values, gender differences, cine MRI
MeSH terms
Adolescent, Adult, Animals, Cardiac Volume, Child, Dogs, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Reference Values, Sex Characteristics, Systole, Observer Variation, Linear Models, Ventricular Function, Left, Ventricular Function, Right, Magnetic Resonance Imaging, Cine

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