Normal Human Left and Right Ventricular and Left Atrial Dimensions Using Steady State Free Precession Magnetic Resonance Imaging
Abstract
Purpose The aim of this project was to establish a database of left and right ventricular and left atrial dimensions in healthy volunteers using steady-state free precession cardiac magnetic resonance imaging, the clinical technique of choice, across a wide age range.Methods 108 healthy volunteers (63 male, 45 female) underwent cardiac magnetic resonance imaging using steady-state free precession sequences. Manual analysis was performed by 2 experienced observers.Results Left and right ventricular volumes and left ventricular mass were larger in males than females: LV end-diastolic volume 160 +/- 29 mL vs. 135 +/- 26 mL, LV end-systolic volume 50 +/- 16 mL vs. 42 +/- 12 mL; RV end-diastolic volume 190 +/- 33 mL vs. 148 +/- 35 mL, RV end-systolic volume 78 +/- 20 mL vs. 56 +/- 18 mL (p < .05 for all). Normalization of values to body surface area removed the statistical differences for LV volumes, but not for LV mass or RV volumes. With increased age, males showed a significant decrease in volume and mass indices for both ventricles, while female values remained unchanged. Compared to females, males had significantly larger maximal left atrial volumes (103 +/- 30 mL vs. 89 +/- 21 mL, p = .01) and left atrial stroke volumes (58 +/- 23 mL vs. 48 +/- 15 mL, p = .01). There was no difference in left atrial ejection fraction between the sexes.Conclusion We have produced a large database of age-related normal ranges for left and right ventricular function and left atrial function in males and females. This will allow accurate interpretation of clinical and research datasets.
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The link between female sex and stroke might vary across populations and age groups.
“The link between female sex and stroke might vary across populations and age groups.75–84”
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- Authors
- Hudsmith†, L., Petersen†, S., Francis, J., Robson, M., & Neubauer, S.
- Affiliations
- John Radcliffe Hospital (GB)
- Venue
- Journal of Cardiovascular Magnetic Resonance
- Publisher
- Elsevier BV
- Published
- 2005-10-01
- Volume
- 7
- Issue
- 5
- Pages
- 775-782
- ISSN
- 1097-6647 (ISSN-L)
- 1532-429X
- OpenAlex
- W2060292275
- Cited by
- 627
- References
- 16
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 19 · 2023: 14 · 2022: 21 · 2021: 42 · 2020: 44 · 2019: 44 · 2018: 35 · 2017: 27 · 2016: 46 · 2015: 50 · 2014: 39 · 2013: 48 · 2012: 34
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cardiovascular Magnetic Resonance (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- reference values, left ventricular dimensions, right ventricular size, left atrial diameter, left ventricular mass, ventricular volume, left atrial ejection fraction, sex differences, age-related changes, body surface area normalization, healthy volunteers
- MeSH terms
- Adult, Age Factors, Aged, Female, Heart Atria, Heart Ventricles, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Sex Factors, Stroke Volume, Reproducibility of Results, Observer Variation, Ventricular Function, Atrial Function, Left, Hypertrophy, Left Ventricular
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