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Cited by 48Exercise and Physiological ResponsesCardiovascular and exercise physiologyCardiac Fibrosis and Remodeling

Interleukin-6 and tumor necrosis factor-α levels increase in response to maximal exercise in patients with chronic heart failure

Kinugawa, Toru, Kato, Masahiko, Ogino, Kazuhide, Osaki, Shuichi, Tomikura, Yoko, Igawa, Osamu, Hisatome, Ichiro, Shigemasa, Chiaki·2003·International Journal of Cardiology
DOI 10.1016/s0167-5273(02)00200-0
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Abstract

Chronic heart failure (CHF) is characterized by the activation of neurohormones and cytokines. Strenuous exercise causes activation of both systems but the effect of acute bouts of exercise on cytokines is not known in patients with CHF. This study determined whether maximal exercise induces activation of cytokines in CHF. Plasma interleukin-6 (IL-6), tumor necrosis factor (TNF)-alpha, epinephrine, norepinephrine, and atrial and brain natriuretic peptides (ANP and BNP) were determined before and after symptom-limited cardiopulmonary exercise testing in 80 patients with CHF (LVEF=38+/-1%, peak VO(2)=18.8+/-0.5 ml/min/kg) and age-matched 33 controls. Resting IL-6 (Controls vs. CHF: 1.3+/-0.2 vs. 2.5+/-0.3 pg/ml, P<0.001) and TNF-alpha (2.7+/-0.2 vs. 3.8+/-0.2 pg/ml, P<0.01) were elevated in CHF. LogIL-6 and logTNF-alpha were positively correlated (r=0.34 and r=0.35, respectively) with logplasma norepinephrine, and were negatively correlated (r=-0.39 and r=-0.32, respectively) with peak VO(2). Maximal exercise increased IL-6 and TNF-alpha both in controls and CHF (all P<0.01). Changes in IL-6 (DeltaIL-6) correlated with Deltaepinephrine (r=0.63, P<0.0001) and Deltanorepinephrine (r=0.57, P=0.0006) in controls, but not in CHF. DeltaTNF-alpha correlated with DeltaANP (r=0.28, P=0.01) only in CHF. In summary, cytokine activation at rest was associated with high plasma norepinephrine and exercise intolerance. Maximal exercise caused increases in IL-6 and TNF-alpha concentrations. Sympathetic activation seems to be important for the IL-6 increase during exercise in controls. In CHF, changes in ANP during exercise were associated with the exercise-induced increase in TNF-alpha, but still unknown mechanisms are involved for the cytokine activation during exercise.

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Crossref · 10.1016/s0167-5273(02)00200-0

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  • IL-6, CCL2 (MCP1), and TNF-α are activated acutely after exercise, partially due to oxidative stress and the DDR, but basal levels are reduced after exercise intervention.

    “For example, recognized proinflammatory SASP factors, interleukin-6 (IL-6), CCL2 (MCP1), and tumor necrosis factor α (TNF-α) are activated acutely after exercise (30), partially due to oxidative stress and the DDR, but basal levels are reduced after exercise intervention.”

    From Exercise Counters the Age-Related Accumulation of Senescent Cells (2022) · cites this paper as [30]

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Authors
Kinugawa, T., Kato, M., Ogino, K., Osaki, S., Tomikura, Y., Igawa, O., Hisatome, I., & Shigemasa, C.
Affiliations
Tottori University Hospital (JP)
Corresponding author
Kinugawa, Toru
ORCID
Venue
International Journal of Cardiology
Publisher
Elsevier BV
Published
2003-01
Volume
87
Issue
1
Pages
83-90
ISSN
0167-5273 (ISSN-L)
DOI
10.1016/s0167-5273(02)00200-0
OpenAlex
W2000731251
Cited by
48
References
44
Citations by year
2025: 2 · 2023: 1 · 2022: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 5 · 2015: 2 · 2014: 1 · 2013: 6 · 2012: 4
FWCI
2.72
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • International Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
chronic heart failure, interleukin-6, TNF-α, cytokines, maximal exercise, cardiopulmonary exercise testing, norepinephrine, epinephrine, atrial natriuretic peptide, brain natriuretic peptide, exercise intolerance, sympathetic activation, neurohormones, peak oxygen uptake, neuroinflammation
MeSH terms
Chronic Disease, Epinephrine, Exercise Test, Female, Heart Failure, Humans, Male, Middle Aged, Atrial Natriuretic Factor, Norepinephrine, Tumor Necrosis Factor-alpha, Interleukin-6, Linear Models, Case-Control Studies, Statistics, Nonparametric, Natriuretic Peptide, Brain

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