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Cited by 245Smoking Behavior and CessationDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Management and Research

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

A prospective study of cigarette smoking and the incidence of diabetes mellitus among us male physicians

Manson, JoAnn E, Ajani, Umed A, Liu, Simin, Nathan, David M, Hennekens, Charles H·2000·The American Journal of Medicine
DOI 10.1016/s0002-9343(00)00568-4
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Abstract

Purpose To determine the association between cigarette smoking and the incidence of type 2 diabetes mellitus.Subjects and methods We studied 21,068 US male physicians aged 40 to 84 years in the Physicians' Health Study who were initially free of diagnosed diabetes mellitus, cardiovascular disease, and cancer. Information about cigarette smoking and other risk indicators was obtained at baseline. The primary outcome was reported diagnosis of type 2 diabetes mellitus.Results During 255,830 person-years of follow-up, 770 new cases of type 2 diabetes mellitus were identified. Smokers had a dose-dependent increased risk of developing type 2 diabetes mellitus: compared with never smokers, the age-adjusted relative risk was 2.1 (95% confidence interval [CI]: 1.7 to 2.6) for current smokers of > or = 20 cigarettes per day, 1.4 (95% CI: 1.0 to 2.0) for current smokers of <20 cigarettes per day, and 1.2 (95% CI: 1.0 to 1.4) for past smokers. After multivariate adjustment for body mass index, physical activity, and other risk factors, the relative risks were 1.7 (95% CI: 1.3 to 2.3) for current smokers of > or = 20 cigarettes per day, 1.5 (95% CI: 1.0 to 2.2) for current smokers of <20 cigarettes per day, and 1.1 (95% CI: 1.0 to 1.4) for past smokers. Total pack-years of cigarette smoking was also associated with the risk of type 2 diabetes mellitus (P for trend <0.001).Conclusions These prospective data support the hypothesis that cigarette smoking is an independent and modifiable determinant of type 2 diabetes mellitus.

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Crossref · 10.1016/s0002-9343(00)00568-4

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  1. Cigarette smoking among adults–United States, 1997. MMWR. 1999;48:993–996.

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Metadata

Authors
Manson, J. E., Ajani, U. A., Liu, S., Nathan, D. M., & Hennekens, C. H.
Affiliations
  • Brigham and Women's Hospital (US)
  • Massachusetts General Hospital (US)
  • Harvard University (US)
Corresponding author
Manson, JoAnn E
ORCID
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
2000-11
Volume
109
Issue
7
Pages
538-542
ISSN
0002-9343 (ISSN-L)
DOI
10.1016/s0002-9343(00)00568-4
OpenAlex
W2039234719
Cited by
245
References
25
Citations by year
2026: 1 · 2025: 5 · 2024: 4 · 2023: 12 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 8 · 2017: 4 · 2016: 10 · 2015: 10 · 2014: 13 · 2013: 7 · 2012: 12
FWCI
4.49
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Cancer Institute (R01CA040360, CA 40360)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 36798, R01DK036798)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
cigarette smoking, type 2 diabetes, diabetes incidence, male physicians, pack-years, modifiable risk factors, Physicians' Health Study
MeSH terms
Adult, Aged, Aged, 80 and over, Diabetes Mellitus, Type 2, Follow-Up Studies, Humans, Male, Middle Aged, Physicians, Prospective Studies, Surveys and Questionnaires, Risk, Risk Factors, Smoking, United States, Incidence, Prevalence

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