Cited by 153Estrogen and related hormone effectsGestational Diabetes Research and ManagementGrowth Hormone and Insulin-like Growth Factors

Metabolic effects of progesterone

Kalkhoff, Ronald K.·1982·American Journal of Obstetrics and Gynecology

Abstract

Progesterone has important effects on carbohydrate, lipid and protein metabolism. This steroid induces hyperinsulinemia, possibly by direct action on pancreatic islets, while promoting glycogen storage in the liver. Paradoxically, it antagonizes the effects of insulin on glucose metabolism in adipose tissue and skeletal muscle. Progesterone stimulates deposition of body fat but had catabolic effects on protein metabolism. Provisional evidence is offered that the steroid may influence ketone body production by the liver as well. When these steroid actions are considered together, their most relevant expression appears to be the physiologic changes observed during normal pregnancy.

Integrity signals

Registry

Crossref · 10.1016/s0002-9378(16)32480-2

Cites

30 of 30 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Estrogen, specifically 17β-estradiol, promotes lipolysis and increases fatty acid availability while decreasing the rate of gluconeogenesis with muscle and liver glycogen sparing.

    “Estrogen, specifically 17β-estradiol, promotes lipolysis and increases fatty acid availability while decreasing the rate of gluconeogenesis with muscle and liver glycogen sparing.”
  • Robust evidence demonstrates that estrogen and progesterone have important roles in regulating substrate metabolism.

    “Robust evidence exists that demonstrates the important roles estrogen and progesterone have in regulating substrate metabolism [20,24,66,70,80,82,84,154–159].”

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Authors
Kalkhoff, R. K.
Affiliations
Medical College of Wisconsin (US)
Corresponding author
Kalkhoff, Ronald K.
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
1982-03
Volume
142
Issue
6
Pages
735-738
ISSN
0002-9378 (ISSN-L)
OpenAlex
W2145204429
Cited by
153
References
30
Citations by year
2026: 3 · 2025: 7 · 2024: 11 · 2023: 11 · 2022: 11 · 2021: 3 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 4
FWCI
2.28
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords
progesterone, carbohydrate metabolism, lipid metabolism, protein metabolism, hyperinsulinemia, pancreatic islets, hepatic glycogen storage, insulin resistance, adipose tissue, skeletal muscle, fat deposition, ketone synthesis, pregnancy
MeSH terms
Adipose Tissue, Female, Humans, Insulin, Ketone Bodies, Muscles, Pregnancy, Progesterone, Proteins, Carbohydrate Metabolism, Lipid Metabolism

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