Interleukin‐6, turnour necrosis factor and soluble turnour necrosis factor receptors in women with pre‐eclampsia

Vince, Gill S.; Starkey, Phyllis M.; Austgulen, Rigmor; Kwiatkowski, Dominic; Redman, Christopher W. G.

doi:10.1111/j.1471-0528.1995.tb09020.x

Cited by 381Pregnancy and preeclampsia studiesNeurological Complications and SyndromesReproductive System and Pregnancy

Interleukin‐6, turnour necrosis factor and soluble turnour necrosis factor receptors in women with pre‐eclampsia

Vince, Gill S., Starkey, Phyllis M., Austgulen, Rigmor, Kwiatkowski, Dominic, Redman, Christopher W. G.·1995·BJOG: An International Journal of Obstetrics & Gynaecology

DOI 10.1111/j.1471-0528.1995.tb09020.x

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Abstract

OBJECTIVES: Generalised maternal endothelial cell dysfunction appears to be an underlying problem in pre-eclampsia presumed to be caused, directly or indirectly, by one or more circulating factors derived from the placenta. Recently it has been suggested that tumour necrosis factor (TNF) may play an important role in pre-eclampsia and contribute to endothelial activation. This study was designed to investigate this proposal. DESIGN: Plasma TNF-alpha, IL-6 and both forms of soluble TNF receptors (p55 and p75 TNF-R) have been measured by ELISA in 31 pre-eclamptic patients and 31 pregnant controls matched for age, parity and gestational age. RESULTS: Levels of IL-6, TNF-alpha and soluble TNF-R (p55 and p75) were significantly higher in pre-eclamptic patients, compared with age and gestation matched controls with a wide variation in levels between pre-eclamptic individuals. There was a correlation between levels of IL-6 and TNF or TNF-R and between TNF and TNF-R levels. However, when the pre-eclamptic patients were subdivided on the basis of the severity of their disease, the median values of plasma concentrations of IL-6, TNF-alpha and TNF-R were all higher in the group with lower platelet counts. CONCLUSIONS: These new findings are consistent with the concept that the maternal syndrome of pre-eclampsia is associated with endothelial dysfunction and provide evidence that at least part of this dysfunction could arise from excessive release of TNF-alpha into the circulation.

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Metformin decreased the expression of vascular cell adhesion molecule 1 (VCAM1) expressed by endothelial cells that are dysfunctional or have been stimulated by incubation with tumor necrosis factor alpha (TNF-α).
“Metformin also decreased the expression of vascular cell adhesion molecule 1 (VCAM1), expressed by endothelial cells that are dysfunctional or have been stimulated by incubation with tumor necrosis factor alpha (TNF-α), a cytokine increased in the circulation of patients with preeclampsia(190–195).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [190]

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Authors: Vince, G. S., Starkey, P. M., Austgulen, R., Kwiatkowski, D., & Redman, C. W. G.
Affiliations: John Radcliffe Hospital (GB)
University of Oxford (GB)
Norwegian University of Science and Technology (NO)
Corresponding author: Vince, Gill S.
ORCID: Austgulen, Rigmor
Kwiatkowski, Dominic
Redman, Christopher W. G.
Venue: BJOG: An International Journal of Obstetrics & Gynaecology
Publisher: Wiley
Published: 1995-01
Volume: 102
Issue: 1
Pages: 20-25
ISSN: 0306-5456 (ISSN-L)
1470-0328
1471-0528
DOI: 10.1111/j.1471-0528.1995.tb09020.x
OpenAlex: W2017673011
Cited by: 381
References: 43
Citations by year: 2025: 2 · 2024: 1 · 2023: 8 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 9 · 2015: 11 · 2014: 16 · 2013: 16 · 2012: 20
FWCI: 20.61
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3883 d)
Locations: BJOG An International Journal of Obstetrics & Gynaecology (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords: preeclampsia, interleukin-6, TNF-α, endothelial dysfunction, plasma cytokines, platelet count, disease severity, placenta
MeSH terms: Adult, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoenzyme Techniques, Pre-Eclampsia, Pregnancy, Tumor Necrosis Factor-alpha, Interleukin-6, Receptors, Interleukin, Receptors, Tumor Necrosis Factor, Receptors, Interleukin-6

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Interleukin‐6, turnour necrosis factor and soluble turnour necrosis factor receptors in women with pre‐eclampsia

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