Active Caspase-6 and Caspase-6-Cleaved Tau in Neuropil Threads, Neuritic Plaques, and Neurofibrillary Tangles of Alzheimer's Disease

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

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A Unified Model for Apical Caspase Activation

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Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease

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Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation

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Effects of environmental enrichment on gene expression in the brain

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Caspase Cleavage of Keratin 18 and Reorganization of Intermediate Filaments during Epithelial Cell Apoptosis

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Activation of Caspase-3 in Single Neurons and Autophagic Granules of Granulovacuolar Degeneration in Alzheimer's Disease

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Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease

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Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis

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The effects of aging on gene expression in the hypothalamus and cortex of mice

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Evidence for the Involvement of Apoptosis-Inducing Factor–Mediated Caspase-Independent Neuronal Death in Alzheimer Disease

Yu, W., Mechawar, N., Krantic, S. M., & Quirion, R. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090496 · Cited by 57

Regulation of Caspases in the Nervous System

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An Optimized Activity-Based Probe for the Study of Caspase-6 Activation

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Caspase‐6 as a novel early target in the treatment of Alzheimer's disease

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The crystal structure of caspase-6, a selective effector of axonal degeneration

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Proteolytic Cleavage of Polymeric Tau Protein by Caspase-3: Implications for Alzheimer Disease

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Non-Canonical Roles of Apoptotic Caspases in the Nervous System

Dehkordi, M. H., Munn, R. G. K., & Fearnhead, H. O. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.840023 · Cited by 56

Identification of Caspase-6-Mediated Processing of the Valosin Containing Protein (p97) in Alzheimer's Disease: A Novel Link to Dysfunction in Ubiquitin Proteasome System-Mediated Protein Degradation

Halawani, D., Tessier, S., Anzellotti, D., Bennett, D. A. A., Latterich, M., & LeBlanc, A. C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5874-09.2010 · Cited by 54

Synthesis and in Vitro Evaluation of Sulfonamide Isatin Michael Acceptors as Small Molecule Inhibitors of Caspase-6

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Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats

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Management of Alzheimer’s disease—An insight of the enzymatic and other novel potential targets

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A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals

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Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment

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Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging: what markers can we use?

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Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice

Wong, B. K. Y., Ehrnhoefer, D. E., Graham, R. K., Martin, D. D. O., Ladha, S., Uribe, V., Stanek, L. M., Franciosi, S., Qiu, X., Deng, Y., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.12.030 · Cited by 50

The self-perpetuating tau truncation circle

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The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration

Alberghina, L., & Colangelo, A. M. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-s1-s2 · Cited by 51

Pharmacological Inhibition of Caspase-2 Protects Axotomised Retinal Ganglion Cells from Apoptosis in Adult Rats

Vigneswara, V., Berry, M., Logan, A., & Ahmed, Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0053473 · Cited by 51

The Triggering Receptor Expressed on Myeloid Cells 2: “TREM-ming” the Inflammatory Component Associated with Alzheimer's Disease

Rohn, T. T. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/860959 · Cited by 51

Decreased drebrin mRNA expression in Alzheimer disease: Correlation with tau pathology

Julien, C., Tremblay, C., Bendjelloul, F., Phivilay, A., Coulombe, M., Émond, V., & Calon, F. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21667 · Cited by 51

Caspase-6 Activity in a BACHD Mouse Modulates Steady-State Levels of Mutant Huntingtin Protein But Is Not Necessary for Production of a 586 Amino Acid Proteolytic Fragment

Gafni, J., Papanikolaou, T., DeGiacomo, F., Holcomb, J., Chen, S., Menalled, L., Kudwa, A. E., Fitzpatrick, J., Miller, S., Ramboz, S., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6379-11.2012 · Cited by 48

Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures.

Sivananthan, S., Lee, A. W., Goodyer, C. G., & LeBlanc, A. C. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.74 · Cited by 48

Cerebrospinal Fluid Tau Cleaved by Caspase-6 Reflects Brain Levels and Cognition in Aging and Alzheimer Disease

Ramcharitar, J., Albrecht, S., Afonso, V. M., Kaushal, V., Bennett, D. A., & LeBlanc, A. C. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182a0a39f · Cited by 47

Newly Identified Function of Caspase-6 in ZBP1-mediated Innate Immune Responses, NLRP3 Inflammasome Activation, PANoptosis, and Host Defense

Zheng, M., & Kanneganti, T. (2020) · Journal of Cellular Immunology · doi:10.33696/immunology.2.064 · Cited by 47

p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin

Ehrnhoefer, D. E., Skotte, N. H., Ladha, S., Nguyen, Y. T. N., Qiu, X., Deng, Y., Huynh, K. T., Engemann, S., Nielsen, S. M., Bečanović, K., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt458 · Cited by 46

Proteomics of Alzheimer’s disease: understanding mechanisms and seeking biomarkers

Lovestone, S., Güntert, A., Hye, A., Lynham, S., Thambisetty, M., & Ward, M. A. (2007) · Expert Review of Proteomics · doi:10.1586/14789450.4.2.227 · Cited by 46

Caspase Activation in Alzheimer's Disease: Early to Rise and Late to Bed

Rohn, T. T., & Head, E. (2008) · Reviews in the Neurosciences · doi:10.1515/revneuro.2008.19.6.383 · Cited by 46

Apoptosis is secondary to non-apoptotic axonal degeneration in neurons exposed to Aβ in distal axons

Song, M.-S., Saavedra, L., & de Chaves, E. I. P. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.06.007 · Cited by 40

Strategic Role for Mitochondria in Alzheimer's Disease and Cancer

Hedskog, L., Zhang, S., & Ankarcrona, M. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4259 · Cited by 45

Palmitoylation of caspase-6 by HIP14 regulates its activation

Skotte, N. H., Sanders, S. S., Singaraja, R. R., Ehrnhoefer, D. E., Vaid, K., Qiu, X., Kannan, S., Verma, C. S., & Hayden, M. R. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.139 · Cited by 45

Apoptosis versus axon pruning: Molecular intersection of two distinct pathways for axon degeneration

Geden, M. J., Romero, S. E., & Deshmukh, M. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.11.007 · Cited by 50

Stress-Induced Tau Phosphorylation: Functional Neuroplasticity or Neuronal Vulnerability?

Rissman, R. A. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1153 · Cited by 43

Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice

Flores, J., Fillion, M.-L., & LeBlanc, A. C. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05290-x · Cited by 44

N-terminal tau truncation in the pathogenesis of Alzheimer's disease (AD): Developing a novel diagnostic and therapeutic approach

Amadoro, G., Latina, V., Corsetti, V., & Calissano, P. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165584 · Cited by 44

Hyperphosphorylation of microtubule-associated tau protein plays dual role in neurodegeneration and neuroprotection

Zhang, Y., Tian, Q., Zhang, Q., Zhou, X., Liu, S., & Wang, J. (2009) · Pathophysiology · doi:10.1016/j.pathophys.2009.02.003 · Cited by 42

Caspase substrates and neurodegenerative diseases

Bulat, N., & Widmann, C. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.07.007 · Cited by 42

Tau‐tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP‐17 tau‐mutant mice

Xu, J., Sato, S., Okuyama, S., Swan, R. J., Jacobsen, M. T., Strunk, E., & Ikezu, T. (2010) · The FASEB Journal · doi:10.1096/fj.09-150144 · Cited by 43

Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer’s disease and not in other tauopathies

Pires, G., McElligott, S., Drusinsky, S., Halliday, G. M., Potier, M., Wısnıewskı, T., & Drummond, E. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0848-6 · Cited by 41

Insoluble Vascular Amyloid Deposits Trigger Disruption of the Neurovascular Unit in Alzheimer’s Disease Brains

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Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine

Pakavathkumar, P., Sharma, G., Kaushal, V., Foveau, B., & LeBlanc, A. C. (2015) · Scientific Reports · doi:10.1038/srep13730 · Cited by 39

Caspase 6 expression in the rat hippocampus during epileptogenesis and epilepsy

Narkilahti, S., & Pitkänen, A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.013 · Cited by 38

Co-localization of hyperphosphorylated tau and caspases in the brainstem of Alzheimer’s disease patients

Wai, M. S. M., Liang, Y., Shi, C., Cho, E. Y. P., Kung, H., & Yew, D. T. W. (2008) · Biogerontology · doi:10.1007/s10522-008-9189-8 · Cited by 37

Caspase-6 activity predicts lower episodic memory ability in aged individuals

Ramcharitar, J., Afonso, V. M., Albrecht, S., Bennett, D. A., & LeBlanc, A. C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.01.007 · Cited by 37

Tau truncation in the pathogenesis of Alzheimer’s disease: a narrative review

Chu, D., Yang, X., Wang, J., Zhou, Y., Gu, J., Miao, J., Wu, F., & Liu, F. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.385853 · Cited by 39

Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice

Zhou, L., Flores, J., Noël, A., Beauchet, O., Sjöström, P. J., & LeBlanc, A. C. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0856-6 · Cited by 36

CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice: Implications in Alzheimer’s Disease

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NLRP1 Inflammasome Activation in the Hippocampal Formation in Alzheimer’s Disease: Correlation with Neuropathological Changes and Unbiasedly Estimated Neuronal Loss

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Differential regulation of inhibitors of apoptosis proteins in Alzheimer’s disease brains

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Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

Heise, C. E., Murray, J. M., Augustyn, K. E., Bravo, B. J., Chugha, P., Cohen, F., Giannetti, A. M., Gibbons, P., Hannoush, R. N., Hearn, B. R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050864 · Cited by 36

Regulation of CRE-dependent transcription by presenilins: prospects for therapy of Alzheimer's disease

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Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization

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DNA Damage Response and Repair, DNA Methylation, and Cell Death in Human Neurons and Experimental Animal Neurons Are Different

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Inhibitory Mechanism of Caspase-6 Phosphorylation Revealed by Crystal Structures, Molecular Dynamics Simulations, and Biochemical Assays

Cao, Q., Wang, X., Liu, C., Liu, D.-F., Li, L., Gao, Y.-Q., & Su, X. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.351213 · Cited by 34

Sp3 and Sp4 Transcription Factor Levels Are Increased in Brains of Patients with Alzheimer’s Disease

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Alzheimer’s disease: phenotypic approaches using disease models and the targeting of tau protein

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Propofol Attenuates Inflammatory Damage via Inhibiting NLRP1-Casp1-Casp6 Signaling in Ischemic Brain Injury.

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Protein Aggregation in Alzheimers Disease and Other Neoropathological Disorders

Dimakopoulos, A. C. (2005) · Current Alzheimer Research · doi:10.2174/1567205052772795 · Cited by 33

Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment

Foveau, B., Albrecht, S., Bennett, D. A., Correa, J. A., & LeBlanc, A. C. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0400-x · Cited by 35

Microglial pyroptosis: Therapeutic target in secondary brain injury following intracerebral hemorrhage

Gu, L., Sun, M., Li, R., Tao, Y., Xu, L., Zhang, X., Yuan, Y., & Xie, Z. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.971469 · Cited by 31

Phosphorylation of Tau Protein Associated as a Protective Mechanism in the Presence of Toxic, C-Terminally Truncated Tau in Alzheimer's Disease

Luna‐Muñoz, J., Charles, R., Claude, M., Flores-Rodríguez, P., Ávila, J., Sergio, R., de la Cruz, F., Mena, R., Meraz‐Ríos, M. A., & Florán, B. (2013) · InTech eBooks · doi:10.5772/54228 · Cited by 43

Amyloid-beta induced retrograde axonal degeneration in a mouse tauopathy model

Nishioka, C., Liang, H.-F., Barsamian, B., & Sun, S.-W. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.01.007 · Cited by 30

Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions

Dagbay, K. B., & Hardy, J. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704640114 · Cited by 30

Amyloid beta1-42 peptide regulates microtubule stability independently of tau

Pianu, B., Lefort, R., Thuiliere, L., Tabourier, E., & Bartolini, F. (2014) · Journal of Cell Science · doi:10.1242/jcs.143750 · Cited by 30

Death Receptor 6 and Caspase-6 Regulate Prion Peptide-Induced Axonal Degeneration in Rat Spinal Neurons

Wang, Y., Zhao, D., Pan, B., Song, Z., Shah, S. Z. A., Yin, X., Zhou, X., & Yang, L. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0562-1 · Cited by 31

Thioredoxin system as a gatekeeper in caspase-6 activation and nuclear lamina integrity: Implications for Alzheimer's disease

Islam, M. R., Nagakannan, P., Ogungbola, O., Djordjevic, J., Albensi, B. C., & Eftekharpour, E. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.02.010 · Cited by 30

Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis

MacPherson, D. J., Mills, C. L., Ondrechen, M. J., & Hardy, J. A. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005914 · Cited by 28

Nitric oxide differentially regulates the gene expression of caspase genes but not some autophagic genes

Rabkin, S. W., & Klassen, S. S. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.10.007 · Cited by 28

Proposed mechanisms of tau: relationships to traumatic brain injury, Alzheimer’s disease, and epilepsy

Martin, S. P., & Leeman-Markowski, B. A. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2023.1287545 · Cited by 30

Identification of Allosteric Inhibitors against Active Caspase-6

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A Quantitative Method for the Specific Assessment of Caspase-6 Activity in Cell Culture

Ehrnhoefer, D. E., Skotte, N. H., Savill, J. M., Nguyen, Y. T. N., Ladha, S., Cao, L., Dullaghan, E. M., & Hayden, M. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027680 · Cited by 28

Caspase-3 cleaved spectrin colocalizes with neurofilament-immunoreactive neurons in Alzheimer’s disease

Ayala‐Grosso, C. A., Tam, J. P., Roy, S., Xanthoudakis, S., Costa, D. D., Nicholson, D. W., & Robertson, G. S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.041 · Cited by 28

The expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer’s disease

Yu, W., Bonnet, M., Farso, M. C., Ma, K., Chabot, J., Martin, E., Torriglia, A., Guan, Z.-Z., McLaurin, J., Quirion, R., et al. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-73 · Cited by 29

Importance of the Caspase Cleavage Site in Amyloid-β Protein Precursor

Bredesen, D. E., John, V., & Galván, V. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100537 · Cited by 27

Expression and Activation of Caspase-6 in Human Fetal and Adult Tissues

Godefroy, N., Foveau, B., Albrecht, S., Goodyer, C. G., & LeBlanc, A. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079313 · Cited by 27

Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice

Pakavathkumar, P., Noël, A., Lecrux, C., Tubeleviciute-Aydin, A., Hamel, É., Ahlfors, J.-E. W., & LeBlanc, A. C. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0166-z · Cited by 27

Activation of caspase‐6 and cleavage of caspase‐6 substrates is an early event in NMDA receptor–mediated excitotoxicity

Girling, K., Demers, M., Lainé, J., Zhang, S., Wang, Y. T., & Graham, R. K. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24153 · Cited by 26

Halting of Caspase Activity Protects Tau from MC1-Conformational Change and Aggregation

Mead, E., Kestoras, D., Gibson, Y., Hamilton, L., Goodson, R. J., Jones, S., Eversden, S., Davies, P., O’Neill, M. J., Hutton, M. L., et al. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150960 · Cited by 26

Identification of Caspase-6 as a New Regulator of Alternatively Activated Macrophages

Yao, Y., Shi, Q., Chen, B., Wang, Q., Li, X., Li, L., Huang, Y., Ji, J., & Shen, P. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.717868 · Cited by 25

Caspase-Mediated Truncation of Tau Potentiates Aggregation

Lee, S., & Shea, T. B. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/731063 · Cited by 25

Elucidating the Multi-Targeted Role of Nutraceuticals: A Complementary Therapy to Starve Neurodegenerative Diseases

Behl, T., Kaur, G., Sehgal, A., Singh, S., Bhatia, S., Al‐Harrasi, A., Zengin, G., BUNGAU, S. G., Munteanu, M. A., Brisc, M. C., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084045 · Cited by 25

Diabetes and Alzheimer's Disease - Is There a Connection?

Sima, A. A. F., & Li, Z.-G. (2006) · The Review of Diabetic Studies · doi:10.1900/rds.2006.3.161 · Cited by 25

Caspase‐6‐cleaved tau is relevant in Alzheimer's disease and marginal in four‐repeat tauopathies: Diagnostic and therapeutic implications

Theofilas, P., Piergies, A. M. H., Oh, I. M., Lee, Y. B., Li, S. H., Pereira, F. L., Petersen, C., Ehrenberg, A. J., Eser, R. A., Ambrose, A. J., et al. (2022) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12819 · Cited by 22

Pathological Impact of Tau Proteolytical Process on Neuronal and Mitochondrial Function: a Crucial Role in Alzheimer’s Disease

Olesen, M. A., & Quintanilla, R. A. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03434-4 · Cited by 23

Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD

Riechers, S., Butland, S. L., Deng, Y., Skotte, N. H., Ehrnhoefer, D. E., Russ, J., Lainé, J., Laroche, M., Pouladi, M. A., Wanker, E. E., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw036 · Cited by 22

Gliotoxin induces caspase-dependent neurite degeneration and calpain-mediated general cytotoxicity in differentiated human neuroblastoma SH-SY5Y cells

Axelsson, V., Holback, S., Sjögren, M., Gustafsson, H., & Forsby, A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.019 · Cited by 22

The hunt for dying neurons: Insight into the neuronal loss in Alzheimer's disease

Žilková, M., Koson, P., & Žilka, N. (2006) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.1007/bf03656855 · Cited by 22

Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity

Opland, C. K., Bryan, M. R., Harris, B., McGillion-Moore, J., Tian, X., Chen, Y., Itano, M. S., Diering, G. H., Meeker, R. B., & Cohen, T. J. (2023) · iScience · doi:10.1016/j.isci.2023.106905 · Cited by 21

A Whole Cell Assay to Measure Caspase-6 Activity by Detecting Cleavage of Lamin A/C

Mintzer, R., Ramaswamy, S., Shah, K., Hannoush, R. N., Pozniak, C. D., Cohen, F., Zhao, X., Plise, E. G., Lewcock, J. W., & Heise, C. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030376 · Cited by 20

Alternatively Spliced Caspase-6B Isoform Inhibits the Activation of Caspase-6A

Lee, A. W., Champagne, N., Wang, X., Su, X., Goodyer, C. G., & LeBlanc, A. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152744 · Cited by 20

Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6

Noël, A., Zhou, L., Foveau, B., Sjöström, P. J., & LeBlanc, A. C. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-017-0043-x · Cited by 20

Necrosis Links Neurodegeneration and Neuroinflammation in Neurodegenerative Disease

Homma, H., Tanaka, H., Fujita, K., & Okazawa, H. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073636 · Cited by 20

Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding

Dagbay, K. B., Bolik-Coulon, N., Savinov, S. N., & Hardy, J. A. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.773499 · Cited by 19

Etoricoxib and Diclofenac Might Reduce the Risk of Dementia in Patients with Osteoarthritis: A Nation-Wide, Population-Based Retrospective Cohort Study

Xue, Y., Peng, Y.-S., Ting, H.-F., Hsieh, J. P., Huang, Y.-K., Wang, Y., Chiou, J., & Wei, J. C. (2018) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000485176 · Cited by 18

The concealed side of caspases: beyond a killer of cells

Abdelghany, L., Sillapachaiyaporn, C., & Zhivotovsky, B. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05495-7 · Cited by 19

Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits

Noël, A., Foveau, B., & LeBlanc, A. C. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03506-0 · Cited by 16

Influence of Tau on Neurotoxicity and Cerebral Vasculature Impairment Associated with Alzheimer’s Disease

Rather, M. A., Khan, A., Jahan, S., Siddiqui, A. J., & Wang, L. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.05.042 · Cited by 18

Inflammation and Programmed Cell Death in Alzheimer’s Disease: Comparison of the Central Nervous System and Peripheral Blood

Macchi, B., Marino‐Merlo, F., Frezza, C., Cuzzocrea, S., & Mastino, A. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8641-9 · Cited by 15

Protein Truncation as a Common Denominator of Human Neurodegenerative Foldopathies

Jadhav, S., Žilka, N., & Novák, M. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8440-8 · Cited by 15

A caspase-6-cleaved fragment of Glial Fibrillary Acidic Protein as a potential serological biomarker of CNS injury after cardiac arrest

Jonesco, D. S., Hassager, C., Frydland, M. S., Kjærgaard, J., Karsdal, M. A., & Henriksen, K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224633 · Cited by 15

Anchored FRET sensors detect local caspase activation prior to neuronal degeneration

Figueroa, R. A., Ramberg, V., Gatsinzi, T., Samuelsson, M., Zhang, M., Iverfeldt, K., & Hallberg, E. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-35 · Cited by 14

O1‐06–08: Caspase‐6 activation disrupts the human neuronal cytoskeleton: Strong implication for an early cause of neuronal disruption in mild cognitively impaired and Alzheimer's disease individuals

LeBlanc, A. C. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.263

Targets of Caspase-6 Activity in Human Neurons and Alzheimer Disease

Klaiman, G., Petzke, T. L., Hammond, J., & LeBlanc, A. C. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m800007-mcp200 · Cited by 118

Targets of Caspase-6 Activity in Human

(2014)

Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer’s disease.

LeBlanc, A., Liu, H., Goodyer, C., Bergeron, C., & Hammond, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23426 · Cited by 232

Caspase-6 activation in Alzheimer's disease and neuronal apoptosis

Guo, H. (2004) · eScholarship@McGill (McGill) · doi:10.82308/17727