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Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer’s disease.
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Caspase-3, -6 and -8 cleave APP mainly between amino acids V664-D665 (APP695 numbering) within the intracytoplasmic domain.
“Several studies have demonstrated in a variety of culture cell systems the ability of caspase-3, -6 and -8 to cleave APP, mainly between amino acids V664-D665 (APP695 numbering) within the intracytoplasmic domain (Gervais et al., 1999; LeBlanc et al., 1999; Pellegrini et al., 1999; Weidemann et al., 1999).”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as LeBlanc et al., 1999
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RETRACTED ARTICLE: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
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Metadata
- Authors
- LeBlanc, A., Liu, H., Goodyer, C., Bergeron, C., & Hammond, J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 274
- Issue
- 33
- Pages
- 23426-23436
- ISSN
- 0021-9258
- Cited by
- 232
- References
- 9
- Language
- en
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