The effects of aging on gene expression in the hypothalamus and cortex of mice
Open accessAbstract
A better understanding of the molecular effects of aging in the brain may help to reveal important aspects of organismal aging, as well as processes that lead to age-related brain dysfunction. In this study, we have examined differences in gene expression in the hypothalamus and cortex of young and aged mice by using high-density oligonucleotide arrays. A number of key genes involved in neuronal structure and signaling are differentially expressed in both the aged hypothalamus and cortex, including synaptotagmin I, cAMP-dependent protein kinase C β, apolipoprotein E, protein phosphatase 2A, and prostaglandin D. Misregulation of these proteins may contribute to age-related memory deficits and neurodegenerative diseases. In addition, many proteases that play essential roles in regulating neuropeptide metabolism, amyloid precursor protein processing, and neuronal apoptosis are up-regulated in the aged brain and likely contribute significantly to brain aging. Finally, a subset of these genes whose expression is affected by aging are oppositely affected by exposure of mice to an enriched environment, suggesting that these genes may play important roles in learning and memory.
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Gene expression profiling studies of ageing mouse, rat, monkey and human brains have shown significant changes in the expression of synaptic genes.
“Gene expression profiling studies of ageing mouse, rat, monkey and human brains have shown significant changes in the expression of synaptic genes (7–13).”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [9]
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- Authors
- Jiang, C. H., Tsien, J. Z., Schultz, P. G., & Hu, Y.
- Affiliations
- Genomics Institute of the Novartis Research Foundation (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2001-02-13
- Volume
- 98
- Issue
- 4
- Pages
- 1930-1934
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC29359
- OpenAlex
- W2083076197
- Cited by
- 318
- References
- 47
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 9 · 2021: 10 · 2020: 12 · 2019: 7 · 2018: 7 · 2017: 11 · 2016: 16 · 2015: 9 · 2014: 7 · 2013: 13 · 2012: 14
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- brain aging, gene expression, hypothalamus, cerebral cortex, age-related memory decline, neurodegenerative diseases, synaptotagmin-1, apolipoprotein E, protein phosphatase 2A, proteolytic enzymes, neuropeptide metabolism, APP processing, neuronal apoptosis, environmental enrichment, learning and memory
- MeSH terms
- Aging, Animals, Cerebral Cortex, Enzyme Induction, Enzymes, Hypothalamus, Mice, Inbred BALB C, Endopeptidases, Stress, Physiological, Synapses, Gene Expression, Neurodegenerative Diseases, Gene Expression Profiling, Mice
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