Cited by 399Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

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CD36, a Class B Scavenger Receptor, Is Expressed on Microglia in Alzheimer's Disease Brains and Can Mediate Production of Reactive Oxygen Species in Response to β-Amyloid Fibrils

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Coraci, Indra Sethy, Husemann, Jens, Berman, Joan W., Hulette, Christine, Dufour, Jennifer H., Campanella, Gabriele K., Luster, Andrew D., Silverstein, Samuel C., El Khoury, Joseph B.·2002·The American Journal of Pathology

DOI 10.1016/s0002-9440(10)64354-4PMC PMC1867121

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Abstract

A pathological hallmark of Alzheimer's disease is the senile plaque, composed of beta-amyloid fibrils, microglia, astrocytes, and dystrophic neurites. We reported previously that class A scavenger receptors mediate adhesion of microglia and macrophages to beta-amyloid fibrils and oxidized low-density lipoprotein (oxLDL)-coated surfaces. We also showed that CD36, a class B scavenger receptor and an oxLDL receptor, promotes H(2)O(2) secretion by macrophages adherent to oxLDL-coated surfaces. Whether CD36 is expressed on microglia, and whether it plays a role in secretion of H(2)O(2) by microglia interacting with fibrillar beta-amyloid is not known. Using fluorescence-activated cell sorting analysis and immunohistochemistry, we found that CD36 is expressed on human fetal microglia, and N9-immortalized mouse microglia. We also found that CD36 is expressed on microglia and on vascular endothelial cells in the brains of Alzheimer's disease patients. Bowes human melanoma cells, which normally do not express CD36, gained the ability to specifically bind to surfaces coated with fibrillar beta-amyloid when transfected with a cDNA encoding human CD36, suggesting that CD36 is a receptor for fibrillar beta-amyloid. Furthermore, two different monoclonal antibodies to CD36 inhibited H(2)O(2) production by N9 microglia and human macrophages adherent to fibrillar beta-amyloid by approximately 50%. Our data identify a role for CD36 in fibrillar beta-amyloid-induced H(2)O(2) production by microglia, and imply that CD36 can mediate binding to fibrillar beta-amyloid. We propose that similar to their role in the interaction of macrophages with oxLDL, class A scavenger receptors and CD36 play complimentary roles in the interactions of microglia with fibrillar beta-amyloid.

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Authors: Coraci, I. S., Husemann, J., Berman, J. W., Hulette, C., Dufour, J. H., Campanella, G. K., Luster, A. D., Silverstein, S. C., & El Khoury, J. B.
Affiliations: Columbia University Irving Medical Center (US)
Albert Einstein College of Medicine (US)
Duke University (US)
Harvard University (US)
ORCID: Berman, Joan W.
Luster, Andrew D.
Venue: The American Journal of Pathology
Publisher: Elsevier BV
Published: 2002-01
Volume: 160
Issue: 1
Pages: 101-112
ISSN: 0002-9440 (ISSN-L)
DOI: 10.1016/s0002-9440(10)64354-4
PMC: PMC1867121
OpenAlex: W2096519700
Cited by: 398
References: 56
Citations by year: 2026: 6 · 2025: 18 · 2024: 13 · 2023: 10 · 2022: 16 · 2021: 18 · 2020: 29 · 2019: 17 · 2018: 10 · 2017: 16 · 2016: 16 · 2015: 18 · 2014: 29 · 2013: 18 · 2012: 33
FWCI: 7.59
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: American Journal Of Pathology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke
National Heart, Lung, and Blood Institute (PO1-AG02219, P50-AG05138)
Alzheimer's Association (R37-AI 20516)
National Institute of Allergy and Infectious Diseases (HL43310)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: CD36, scavenger receptor class B, microglia, Alzheimer's disease, amyloid-beta fibrils, reactive oxygen species, hydrogen peroxide production, amyloid plaques, vascular endothelial cells, monoclonal antibody inhibition
MeSH terms: Alzheimer Disease, Animals, Antibodies, Brain, Cell Adhesion, Cell Line, Cell Line, Transformed, Fetus, Humans, Macrophages, Membrane Proteins, Peptide Fragments, Peroxides, Phagocytes, Receptors, Immunologic, Amyloid beta-Peptides, Reactive Oxygen Species, Microglia, Receptors, Lipoprotein, CD36 Antigens, Receptors, Scavenger, Scavenger Receptors, Class A, Scavenger Receptors, Class B, Mice, Rats

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CD36, a Class B Scavenger Receptor, Is Expressed on Microglia in Alzheimer's Disease Brains and Can Mediate Production of Reactive Oxygen Species in Response to β-Amyloid Fibrils

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