Notch2-positive progenitors with the intrinsic ability to give rise to pancreatic ductal cells

Cancer Statistics, 2001

Greenlee, R. T., Hill-Harmon, M. B., Murray, T., & Thun, M. J. (2001) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.51.1.15 · Cited by 3,281 · see citing works

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

Thiebaut, F., TSURUO, T., Hamada, H., Gottesman, M. M., PASTAN, I., & Willingham, M. C. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.21.7735 · Cited by 2,777 · see citing works

Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction

Oh, H., Bradfute, S. B., Gallardo, T. D., Nakamura, T., Gaussin, V., Mishina, Y. M., Pocius, J. S., Michael, L. H., Behringer, R. R., Garry, D. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2132126100 · Cited by 1,739 · see citing works

Vasculogenesis

Risau, W., & Flamme, I. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.000445 · Cited by 1,410 · see citing works

Absence of cancer–associated changes in human fibroblasts immortalized with telomerase

Morales, C. P., Holt, S. E., Ouellette, M. M., Kaur, K. J., Yan, Y., Wilson, K. S., White, M. A., Wright, W. E., & Shay, J. W. (1999) · Nature Genetics · doi:10.1038/5063 · Cited by 805 · see citing works

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

Jiang, X., Jimenez, G. S., Chang, E., Frolkis, M., Kusler, B., Sage, M., Beeche, M., Bodnar, A. G., Wahl, G. M., Tlsty, T. D., et al. (1999) · Nature Genetics · doi:10.1038/5056 · Cited by 668 · see citing works

DNA methylation and chromatin modification

Ng, H.-H., & Adrian, B. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80024-0 · Cited by 648 · see citing works

Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis

Miyamoto, Y., Maitra, A., Ghosh, B., Zechner, U., Argani, P., Iacobuzio-Donahue, C. A., Sriuranpong, V., Iso, T., Meszoely, I. M., Wolfe, M. S., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00140-5 · Cited by 643 · see citing works

Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression.

Wilentz, R. E., Iacobuzio–Donahue, C. A., Argani, P., McCarthy, D. M., Parsons, J. L., Yeo, C. J., Kern, S. E., & Hruban, R. H. (2000) · PubMed · Cited by 591 · see citing works

Human Endothelial Cell Life Extension by Telomerase Expression

Yang, J., Chang, E., Cherry, A. M., Bangs, C. D., Oei, Y. A., Bodnar, A. G., Bronstein, A., Chiu, C., & Herron, G. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26141 · Cited by 499 · see citing works

p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.

Moskaluk, C. A., Hruban, R. H., & Kern, S. E. (1997) · PubMed · Cited by 429 · see citing works

Genetic progression in the pancreatic ducts

Hruban, R. H., Wilentz, R. E., & Kern, S. E. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65054-7 · Cited by 373 · see citing works

Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression.

Wilentz, R. E., Geradts, J., Maynard, R. D., Offerhaus, G. J. A., Kang, M., Goggins, M., Yeo, C. J., Kern, S. E., & Hruban, R. H. (1998) · PubMed · Cited by 337 · see citing works

Growth and spread of hepatocellular carcinoma: A review of 240 consecutive autopsy cases

Yuki, K., Hirohashi, S., Sakamoto, M., Kanai, T., & Shimosato, Y. (1990) · Cancer · doi:10.1002/1097-0142(19901115)66:10 · Cited by 326 · see citing works

Development of Regenerative Cardiomyocytes from Mesenchymal Stem Cells for Cardiovascular Tissue Engineering

Fukuda, K. (2001) · Artificial Organs · doi:10.1046/j.1525-1594.2001.025003187.x · Cited by 243 · see citing works

Allelic Loss Is Often the First Hit in the Biallelic Inactivation of the p53 and DPC4 Genes During Pancreatic Carcinogenesis

Luettges, J., Galehdari, H., Bröcker, V., Schwarte‐Waldhoff, I., Henne‐Bruns, D., Klöppel, G., Schmiegel, W., & Hahn, S. A. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64123-5 · Cited by 241 · see citing works

The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes

Ouellette, M. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.3.403 · Cited by 218 · see citing works

Synergistic Effect of Histone Hyperacetylation and DNA Demethylation in the Reactivation of the FMR1 Gene

Chiurazzi, P., Grazia Pomponi, M., Pietrobono, R., Bakker, C. E., Neri, G., & Oostra, B. A. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.12.2317 · Cited by 217 · see citing works

Nestin expression in pancreatic stellate cells and angiogenic endothelial cells

Lardon, J., Rooman, I., & Bouwens, L. (2002) · Histochemistry and Cell Biology · doi:10.1007/s00418-002-0412-4 · Cited by 215 · see citing works

Malignant transformation of duct-like cells originating from acini in transforming growth factor α transgenic mice

WAGNER, M., Lührs, H., Klöppel, G., Adler, G., & Schmid, R. M. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70098-8 · Cited by 193 · see citing works

Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro

Rooman, I., Heremans, Y., Heimberg, H., & Bouwens, L. (2000) · Diabetologia · doi:10.1007/s001250051468 · Cited by 192 · see citing works

Rapid acinar to ductal transdifferentiation in cultured human exocrine pancreas

Hall, P. A., & Lemoine, N. R. (1992) · The Journal of Pathology · doi:10.1002/path.1711660203 · Cited by 168 · see citing works

Immortalization with telomerase of the Nestin-positive cells of the human pancreas.

Lee, K. M., Nguyen, C., Ulrich, A., Pour, P., & Ouellette, M. (2003) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/s0006-291x(03)00086-x · Cited by 160 · see citing works

Nestin expression in pancreatic exocrine cell lineages

Delacour, A., Népote, V., Trumpp, A., & Herrera, P. L. (2003) · Mechanisms of Development · doi:10.1016/j.mod.2003.11.004 · Cited by 142 · see citing works

Cytokeratins and cell differentiation in the pancreas

Bouwens, L. (1998) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199803)184:3 · Cited by 140 · see citing works

Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas.

Esni, F., Stoffers, D., Takeuchi, T., & Leach, S. (2004) · Mechanisms of Development · doi:10.1016/j.mod.2003.08.010 · Cited by 119 · see citing works

Nestin Is Expressed in Vascular Endothelial Cells in the Adult Human Pancreas

Klein, T., Ling, Z., Heimberg, H., Madsen, O. D., Heller, R. S., & Serup, P. (2003) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540305100601 · Cited by 108 · see citing works

Pancreatic acinar cells in culture: expression of acinar and ductal antigens in a growth-related manner.

Lisle, R. C. D., & Logsdon, C. D. (1990) · PubMed · Cited by 104 · see citing works

Ductal metaplasia of human exocrine pancreas and its association with carcinoma.

Parsa, I., Longnecker, D. S., Scarpelli, D. G., Pour, P. M., Reddy, J. K., & Lefkowitz, M. (1985) · PubMed · Cited by 103 · see citing works

Cancer of the pancreas (nonendocrine): a suggested morphologic classification.

Cubilla, A. L., & FITZGERALD, P. J. (1979) · PubMed · Cited by 74 · see citing works

Soluble markers of endothelial cell function.

Blann, A. D., & Seigneur, M. (1997) · PubMed · Cited by 59 · see citing works

TGFα transgenic mice

Greten, F. R., Wagner, M., Weber, C. K., Zechner, U., Adler, G., & Schmid, R. M. (2001) · Pancreatology · doi:10.1159/000055835 · Cited by 46 · see citing works

Developmental aspects of early pancreatic cancer.

Meszoely, I. M., Means, A. L., Scoggins, C. R., & Leach, S. D. (2001) · PubMed · Cited by 43 · see citing works

Carbonic Anhydrase in Human Pancreas: Hypotheses for the Pathophysiological Roles of CA Isozymes

Nishimori, I., Fujikawa‐Adachi, K., Onishi, S., & Hollingsworth, M. A. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09505.x · Cited by 41 · see citing works

Carbonic Anhydrase II Gene Expression in Cell Lines from Human Pancreatic Adenocarcinoma

Frazier, M. L., Lilly, B., Wu, E. F., Ota, T., & Hewett‐Emmett, D. (1990) · Pancreas · doi:10.1097/00006676-199009000-00002 · Cited by 33 · see citing works

Cytokeratins and mucins as molecular markers of cell differentiation and neoplastic transformation in the exocrine pancreas.

Vilà, M. R., Balagué, C., & Real, F. X. (1994) · PubMed · Cited by 15 · see citing works

Elucidation of a universal size-control mechanism in Drosophila and mammals

Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., & Pan, D. (2007) · Cell · doi:10.1016/j.cell.2007.07.019 · Cited by 2,370 · see citing works

KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma

Ling, J., Kang, Y., Zhao, R., Xia, Q., Lee, D.-F., Chang, Z., Li, J., Peng, B., Fleming, J. B., Wang, H., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2011.12.006 · Cited by 513 · see citing works

Antisense Inhibition of microRNA-21 or -221 Arrests Cell Cycle, Induces Apoptosis, and Sensitizes the Effects of Gemcitabine in Pancreatic Adenocarcinoma

Park, J. K., Lee, E. J., Esau, C., & Schmittgen, T. D. (2009) · Pancreas · doi:10.1097/mpa.0b013e3181ba82e1 · Cited by 287 · see citing works

Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis

Bastidas-Ponce, A., Tritschler, S., Dony, L., Scheibner, K., Tarquis-Medina, M., Salinno, C., Schirge, S., Burtscher, I., Böttcher, A., Theis, F. J., et al. (2019) · Development · doi:10.1242/dev.173849 · Cited by 250 · see citing works

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

Mazur, P. K., Einwächter, H., Lee, M., Sipos, B., Nakhai, H., Rad, R., Zimber‐Strobl, U., Strobl, L. J., Radtke, F., Klöppel, G., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002423107 · Cited by 219 · see citing works

K-Ras Promotes Growth Transformation and Invasion of Immortalized Human Pancreatic Cells by Raf and Phosphatidylinositol 3-Kinase Signaling

Campbell, P. M., Groehler, A. L., Lee, K. M., Ouellette, M. M., Khazak, V., & Der, C. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3752 · Cited by 215 · see citing works

Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer

Feldmann, G., Habbe, N., Dhara, S., Bisht, S., Alvarez, H., Fendrich, V., Beaty, R. M., Mullendore, M. E., Karikari, C. A., Bardeesy, N. M., et al. (2008) · Gut · doi:10.1136/gut.2007.148189 · Cited by 193 · see citing works

KIBRA Regulates Hippo Signaling Activity via Interactions with Large Tumor Suppressor Kinases

Xiao, L., Chen, Y., Ji, M., & Dong, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.173468 · Cited by 190 · see citing works

Inhibiting the Cyclin-Dependent Kinase CDK5 Blocks Pancreatic Cancer Formation and Progression through the Suppression of Ras-Ral Signaling

Feldmann, G., Mishra, A., Hong, S., Bisht, S., Strock, C. J., Ball, D. W., Goggins, M., Maitra, A., & Nelkin, B. D. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-1107 · Cited by 164 · see citing works

Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3

Yang, S., Zhang, L., Purohit, V., Shukla, S. K., Chen, X., Yu, F., Fu, K., Chen, Y., Solheim, J. C., Singh, P. K., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5935 · Cited by 106 · see citing works

Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells

Yuan, Y., Aj, T., Castoreno, A. B., Kuo, S.-Y., Wang, Q., Kuballa, P., Xavier, R. J., Shamji, A. F., Schreiber, S. L., & Bk, W. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.191 · Cited by 105 · see citing works

Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma

Ju, H., Ying, H., Tian, T., Ling, J., Fu, J., Yu, L., Wu, M., Yang, L., Achreja, A., Chen, G., et al. (2017) · Nature Communications · doi:10.1038/ncomms14437 · Cited by 94 · see citing works

Wnt Signaling in Pancreatic Islets

Liu, Z., & Habener, J. F. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-90-481-3271-3_17 · Cited by 92 · see citing works

Overexpression of GalNAc-transferase GalNAc-T3 promotes pancreatic cancer cell growth

Taniuchi, K., Cerny, R. L., Tanouchi, A., Kohno, K., Kotani, N., Honke, K., Saibara, T., & Hollingsworth, M. A. (2011) · Oncogene · doi:10.1038/onc.2011.194 · Cited by 84 · see citing works

Cyclin-Dependent Kinase 5 Is Amplified and Overexpressed in Pancreatic Cancer and Activated by Mutant K-Ras

Eggers, J. P., Grandgenett, P. M., Collisson, E. C., Lewallen, M. E., Tremayne, J. R., Singh, P. K., Swanson, B. J., Andersen, J. M., Caffrey, T. C., High, R., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2288 · Cited by 81 · see citing works

Combined Targeting of STAT3/NF-κB/COX-2/EP4 for Effective Management of Pancreatic Cancer

Gong, J., Xie, J., Bedolla, R. G., Rivas, P., Chakravarthy, D., Freeman, J. W., Reddick, R. L., Kopetz, S., Peterson, A., Wang, H., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1664 · Cited by 74 · see citing works

Class III β‐tubulin, a marker of resistance to paclitaxel, is overexpressed in pancreatic ductal adenocarcinoma and intraepithelial neoplasia

Lee, K. M., Cao, D., Itami, A., Pour, P. M., Hruban, R. H., Maitra, A., & Ouellette, M. M. (2007) · Histopathology · doi:10.1111/j.1365-2559.2007.02792.x · Cited by 73 · see citing works

Transferrin surface-modified PLGA nanoparticles-mediated delivery of a proteasome inhibitor to human pancreatic cancer cells

Frasco, M. F., Almeida, G. M., Santos‐Silva, F., Pereira, M. D. C., & Coelho, M. A. N. (2014) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35286 · Cited by 69 · see citing works

ATP Production Relies on Fatty Acid Oxidation Rather than Glycolysis in Pancreatic Ductal Adenocarcinoma

Lee, J., Oh, S. J., Choi, H.-J., Kang, J. H., Lee, S.-H., Ha, J. S., Woo, S. M., Jang, H., Lee, H., & Kim, S. (2020) · Cancers · doi:10.3390/cancers12092477 · Cited by 68 · see citing works

PR55α subunit of protein phosphatase 2A supports the tumorigenic and metastatic potential of pancreatic cancer cells by sustaining hyperactive oncogenic signaling

Hein, A. L., Seshacharyulu, P., Rachagani, S., Sheinin, Y. M., Ouellette, M. M., Ponnusamy, M. P., Mumby, M. C., Batra, S. K., & Yan, Y. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2119 · Cited by 66 · see citing works

Quinomycin A targets Notch signaling pathway in pancreatic cancer stem cells

Ponnurangam, S., Dandawate, P. R., Dhar, A., Tawfik, O. W., Parab, R., Mishra, P. D., Ranadive, P., Sharma, R. K., Mahajan, G., Umar, S., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6560 · Cited by 64 · see citing works

PLGA nanoparticles as a platform for vitamin D-based cancer therapy

Ramalho, M. J., Loureiro, J. A., Gomes, B., Frasco, M. F., Coelho, M. A. N., & Pereira, M. D. C. (2015) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.6.135 · Cited by 62 · see citing works

Palladin is overexpressed in the non-neoplastic stroma of infiltrating ductal adenocarcinomas of the pancreas, but is only rarely overexpressed in neoplastic cells

Salaria, S. N., Illei, P. B., Sharma, R. B., Walter, K., Klein, A. P., Eshleman, J. R., Maitra, A., Schulick, R. D., Winter, J. M., Ouellette, M. M., et al. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.3.3904 · Cited by 61 · see citing works

Protein phosphatase 2A has an essential role in the activation of γ-irradiation-induced G2/M checkpoint response

Yan, Y., Cao, P. T., Greer, P. M., Nagengast, E. S., Kolb, R. H., Mumby, M. C., & Cowan, K. H. (2010) · Oncogene · doi:10.1038/onc.2010.187 · Cited by 54 · see citing works

CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming

Kendrick, A. A., Schafer, J. B., Dzieciątkowska, M., Nemkov, T. G., D’Alessandro, A., Neelakantan, D., Ford, H. L., Pearson, C. G., Weekes, C. D., Hansen, K. C., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.14272 · Cited by 52 · see citing works

SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer

Zhou, H., Qin, Y., Ji, S., Ling, J., Fu, J., Zhuang, Z., Fan, X., Song, L., Yu, X., & Chiao, P. J. (2017) · Oncogene · doi:10.1038/onc.2017.393 · Cited by 52 · see citing works

LCL124, a Cationic Analog of Ceramide, Selectively Induces Pancreatic Cancer Cell Death by Accumulating in Mitochondria

Beckham, T. H., Lü, P., Jones, E. E., Marrison, S. T., Lewis, C. S., Cheng, J., Ramshesh, V. K., Beeson, G. C., Beeson, C. C., Drake, R. R., et al. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.199216 · Cited by 51 · see citing works

Axl-mediated activation of TBK1 drives epithelial plasticity in pancreatic cancer

Cruz, V. H., Arner, E. N., Du, W., Bremauntz, A. E., & Brekken, R. A. (2019) · JCI Insight · doi:10.1172/jci.insight.126117 · Cited by 47 · see citing works

The N-Terminal Domain of G3BP Enhances Cell Motility and Invasion by Posttranscriptional Regulation of BART

Taniuchi, K., Nishimori, I., & Hollingsworth, M. A. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0574 · Cited by 46 · see citing works

Podocalyxin‐like protein, linked to poor prognosis of pancreatic cancers, promotes cell invasion by binding to gelsolin

Taniuchi, K., Furihata, M., Naganuma, S., Dabanaka, K., Hanazaki, K., & Saibara, T. (2016) · Cancer Science · doi:10.1111/cas.13018 · Cited by 41 · see citing works

Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation

Yan, Y., Hein, A. L., Etekpo, A., Burchett, K. M., Lin, C. H., Enke, C. A., Batra, S. K., Cowan, K. H., & Ouellette, M. M. (2014) · Oncotarget · doi:10.18632/oncotarget.2500 · Cited by 40 · see citing works

Activated Epidermal Growth Factor Receptor as a Novel Target in Pancreatic Cancer Therapy

Gowda, H., Jimeno, A., Molina, H., Mihalas, A. B., Goggins, M., Hruban, R. H., Schulick, R. D., Kamath, U., Maitra, A., Hidalgo, M. M., et al. (2008) · Journal of Proteome Research · doi:10.1021/pr800139r · Cited by 39 · see citing works

An integrated transcriptome and epigenome analysis identifies a novel candidate gene for pancreatic cancer

Jia, J., Parikh, H. M., Xiao, W., Hoskins, J. W., Pflicke, H., Liu, X., Collins, I. J., Zhou, W., Wang, Z., Powell, J. I., et al. (2013) · BMC Medical Genomics · doi:10.1186/1755-8794-6-33 · Cited by 36 · see citing works

Cyclin-dependent kinase 1 (CDK1)-mediated mitotic phosphorylation of the transcriptional co-repressor Vgll4 inhibits its tumor-suppressing activity

Zeng, Y., Stauffer, S., Zhou, J., Chen, X., Chen, Y., & Dong, J. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.796284 · Cited by 35 · see citing works

Comparative evaluation of cancer stem cell markers in normal pancreas and pancreatic ductal adenocarcinoma

Bellone, G. (2011) · Oncology Reports · doi:10.3892/or.2011.1461 · Cited by 33 · see citing works

Oncoprotein YAP Regulates the Spindle Checkpoint Activation in a Mitotic Phosphorylation-dependent Manner through Up-regulation of BubR1

Yang, S., Zhang, L., Chen, X., Chen, Y., & Dong, J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.624411 · Cited by 31 · see citing works

The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer

Qian, W., Chen, K., Qin, T., Xiao, Y., Li, J., Yue, Y., Zhou, C., Ma, J., Duan, W., Lei, J., et al. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01823-4 · Cited by 30 · see citing works

Aberrant expression of a novel circular RNA in pancreatic cancer

Seimiya, T., Otsuka, M., Iwata, T., Tanaka, E., Sekiba, K., Shibata, C., Moriyama, M., Nakagawa, R., Maruyama, R., & Koike, K. (2020) · Journal of Human Genetics · doi:10.1038/s10038-020-00826-5 · Cited by 30 · see citing works

Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution

Monberg, M. E., Geiger, H., Lee, J. J., Sharma, R., Semaan, A., Bernard, V., Wong, J., Wang, F., Liang, S., Swartzlander, D. B., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31376-3 · Cited by 30 · see citing works

Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells

Peters, H. L., Tuli, A., Wang, X., Liu, C., Pan, Z., Ouellette, M. M., Hollingsworth, M. A., MacDonald, R. G., & Solheim, J. C. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1553 · Cited by 29 · see citing works

In vitromodels of pancreatic cancer for translational oncology research

Feldmann, G., Rauenzahn, S. L., & Maitra, A. (2009) · Expert Opinion on Drug Discovery · doi:10.1517/17460440902821657 · Cited by 28 · see citing works

Modelling Duchenne muscular dystrophy in MYOD1-converted urine-derived cells treated with 3-deazaneplanocin A hydrochloride

Takizawa, H., Hara, Y., Mizobe, Y., Ohno, T., Suzuki, S., Inoue, K., Takeshita, E., Shimizu‐Motohashi, Y., Ishiyama, A., Hoshino, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-40421-z · Cited by 27 · see citing works

Simple Detection of Telomere Fusions in Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm, and Pancreatic Cyst Fluid

Hata, T., Molin, M. D., McGregor-Das, A., Song, T. J., Wolfgang, C. L., Eshleman, J. R., Hruban, R. H., & Goggins, M. (2017) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2017.09.006 · Cited by 23 · see citing works

Ras‐Driven Transformation of Human Nestin‐Positive Pancreatic Epithelial Cells

Campbell, P. M., Lee, K. M., Ouellette, M. M., Kim, H. J., Groehler, A. L., Khazak, V., & Der, C. J. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)00431-4 · Cited by 23 · see citing works

Apoptosis-associated speck-like protein containing a CARD regulates the growth of pancreatic ductal adenocarcinoma

Koizumi, M., Watanabe, T., Masumoto, J., Sunago, K., Imamura, Y., Kanemitsu, K., Kumagi, T., & Hiasa, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-01465-2 · Cited by 20 · see citing works

Visceral adipose tissue remodeling in pancreatic ductal adenocarcinoma cachexia: the role of activin A signaling

Xu, P. C., You, M., Yu, S., Luan, Y., Eldani, M., Caffrey, T. C., Grandgenett, P. M., O’Connell, K. A., Shukla, S. K., Kattamuri, C., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-05660-7 · Cited by 20 · see citing works

MARK2 regulates chemotherapeutic responses through class IIa HDAC-YAP axis in pancreatic cancer

Zeng, Y., Yin, L., Zhou, J., Zeng, R., Xiao, Y., Black, A. R., Hu, T., Singh, P. K., Yin, F., Batra, S. K., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02399-3 · Cited by 20 · see citing works

Proteome-Wide Protein Expression Profiling Across Five Pancreatic Cell Lines

Paulo, J. A., Mancias, J. D., & Gygi, S. P. (2017) · Pancreas · doi:10.1097/mpa.0000000000000800 · Cited by 19 · see citing works

Characteristics of Notch2+ pancreatic cancer stem‐like cells and the relationship with centroacinar cells

Zhou, Z., Dong, Q., Fu, D., Gong, Y., & Ni, Q. (2013) · Cell Biology International · doi:10.1002/cbin.10102 · Cited by 18 · see citing works

WAVE2 is associated with poor prognosis in pancreatic cancers and promotes cell motility and invasiveness via binding to ACTN4

Taniuchi, K., Furihata, M., Naganuma, S., & Saibara, T. (2018) · Cancer Medicine · doi:10.1002/cam4.1837 · Cited by 18 · see citing works

Measurement of serum PODXL concentration for detection of pancreatic cancer

Taniuchi, K., Tsuboi, M., Sakaguchi, M., & Saibara, T. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s155367 · Cited by 17 · see citing works

Generation of Hydrogen Peroxide and Downstream Protein Kinase D1 Signaling Is a Common Feature of Inducers of Pancreatic Acinar-to-Ductal Metaplasia

Döppler, H. R., Liou, G., & Störz, P. (2022) · Antioxidants · doi:10.3390/antiox11010137 · Cited by 16 · see citing works

LIMD 1 phosphorylation in mitosis is required for mitotic progression and its tumor‐suppressing activity

Zhou, J., Zhang, L., Wei, Z., Chen, Y., Cheng, Y., & Dong, J. (2019) · FEBS Journal · doi:10.1111/febs.14743 · Cited by 14 · see citing works

Cyclin-dependent kinase 1-mediated phosphorylation of SET at serine 7 is essential for its oncogenic activity

Yin, L., Zeng, Y., Xiao, Y., Chen, Y., Shen, H., & Dong, J. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1621-2 · Cited by 14 · see citing works

Pancreatitis initiated pancreatic ductal adenocarcinoma: Pathophysiology explaining clinical evidence

Tao, X., Xiang, H., Pan, Y., Shang, D., Guo, J., Gao, G., & Xiao, G. G. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105595 · Cited by 13 · see citing works

Activated Pancreatic Stellate Cells Enhance the Warburg Effect to Cause the Malignant Development in Chronic Pancreatitis

Tao, Y., Shao, F., Cai, M., Liu, Z., Peng, Y., Huang, Q., & Meng, F. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.714598 · Cited by 13 · see citing works

The GSK3 kinase and LZTR1 protein regulate the stability of Ras family proteins and the proliferation of pancreatic cancer cells

Palanivel, C., Chaudhary, N., Seshacharyulu, P., Cox, J. L., Yan, Y., Batra, S. K., & Ouellette, M. M. (2022) · Neoplasia · doi:10.1016/j.neo.2022.01.002 · Cited by 12 · see citing works

The scRNA-sequencing landscape of pancreatic ductal adenocarcinoma revealed distinct cell populations associated with tumor initiation and progression

Wang, Y., Bian, Z., Xu, L., Du, G., Qi, Z., Zhang, Y., Long, J., & Li, W. (2024) · Genes & Diseases · doi:10.1016/j.gendis.2024.101323 · Cited by 10 · see citing works

BCL7B, a predictor of poor prognosis of pancreatic cancers, promotes cell motility and invasion by influencing CREB signaling.

Taniuchi, K., Furihata, M., Naganuma, S., Dabanaka, K., Hanazaki, K., & Saibara, T. (2018) · PubMed Central · Cited by 10 · see citing works

Targeting the Yin and the Yang

Gomes, E., Connelly, S. F., & Summy, J. M. (2012) · Pancreas · doi:10.1097/mpa.0b013e3182793fd7 · Cited by 9 · see citing works

Real-Time Monitoring of miRNA Function in Pancreatic Cell Lines Using Recombinant AAV-Based miRNA Asensors

Chen, J., Liu, X., Xue, C., Guo, Z., Liu, J., Hao, J., & Zhang, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066315 · Cited by 9 · see citing works

Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution

Monberg, M. E., Geiger, H. M., Lee, J. J., Sharma, R., Semaan, A., Bernard, V., Wong, J., Wang, F., Liang, S., Swartzlander, D. B., et al. (2022) · RePEc: Research Papers in Economics · Cited by 6 · see citing works

TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress

Anand, J. R., Droby, G. N., Joseph, S., Patel, U., Zhang, X., Klomp, J. A., Der, C. J., Purvis, J. E., Wolff, S. C., Bowser, J. L., et al. (2025) · NAR Cancer · doi:10.1093/narcan/zcaf009 · Cited by 5 · see citing works

HNF1B‐driven three‐dimensional chromatin structure for molecular classification in pancreatic cancers

Kato, H., Tateishi, K., Iwadate, D., Yamamoto, K., Fujiwara, H., Nakatsuka, T., Kudo, Y., Hayakawa, Y., Ijichi, H., Otsuka, M., et al. (2022) · Cancer Science · doi:10.1111/cas.15690 · Cited by 4 · see citing works

Bmi1 combines with oncogenic KRAS to induce malignant transformation of human pancreatic duct cells in vitro

Chen, S.-J., Chen, Y., Zeng, L., Zhang, Q., Lian, G., Li, J., Yang, K., Huang, C., Li, Y., Chu, Z., et al. (2016) · Tumor Biology · doi:10.1007/s13277-016-4840-5 · Cited by 5 · see citing works

PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation

Palanivel, C., Madduri, L. S. V., Hein, A. L., Jenkins, C. B., Graff, B. T., Camero, A. L., Zhou, S., Enke, C. A., Ouellette, M. M., & Yan, Y. (2024) · Aging · doi:10.18632/aging.205619 · Cited by 4 · see citing works

The small heat shock protein αA-crystallin negatively regulates pancreatic tumorigenesis

Liu, J., Luo, Z., Zhang, L., Wang, L., Nie, Q., Wang, Z.-F., Huang, Z., Hu, X., Gong, L., Arrigo, A., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11668 · Cited by 4 · see citing works

Current Knowledge on the Role of Wnt Signaling Pathway in Glucose Homeostasis

Jin, T. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801585-8.00029-4 · Cited by 4 · see citing works

Evaluating Dietary Compounds in Pancreatic Cancer Modeling Systems

Mascariñas, E., Eibl, G., & Grippo, P. J. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-287-2_12 · Cited by 3 · see citing works

Expression of Key Factors of the Hippo Signaling Pathway in Yak (Bos grunniens) Mammary Gland

Du, P., Lü, B., Zhao, L., Yao, Y., Qian, W., Yu, Z., Cui, Y., Yu, S., & Fan, J. (2022) · Animals · doi:10.3390/ani12162103 · Cited by 3 · see citing works

From Research to the Clinic

Gurney, A. L., & Hoey, T. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803892-5.00017-6 · Cited by 2 · see citing works

Rac1 GTPase Regulates the βTrCP-Mediated Proteolysis of YAP Independently of the LATS1/2 Kinases

Palanivel, C., Somers, T. N., Gabler, B. M., Chen, Y., Zeng, Y., Cox, J. L., Seshacharyulu, P., Dong, J., Yan, Y., Batra, S. K., et al. (2024) · Cancers · doi:10.3390/cancers16213605 · Cited by 3 · see citing works

Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolutionPreprint

Monberg, M. E., Geiger, H., Lee, J. J., Sharma, R., Semaan, A., Bernard, V., Swartzlander, D. B., Stephens, B. M., Chen, K., Katz, M. H., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.13.439717 · Cited by 2 · see citing works

Altered Responses to Endoplasmic Reticulum Stress in Pancreatic Cancer

Choe, J. H. (2011) · Digital Commons-TMC (Texas Medical Center) · Cited by 2 · see citing works

PR55α subunit of protein phosphatase 2A supports KRASG12D-driven tumorigenesis that requires YAP activation

Jenkins, C. B., Camero, A. L., Graff, B. T., Madduri, L. S. V., O’Connell, K. A., Hein, A. L., Smith, L. M., Enke, C. A., Dong, J., Hollingsworth, M. A., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03477-y · Cited by 1 · see citing works

Molecular Signaling Pathways in Pancreatic Cancer

Boland, G. M., & Thayer, S. P. (2008) · Springer eBooks · doi:10.1007/978-0-387-69252-4_11 · Cited by 1 · see citing works

Wnt Signaling in Pancreatic Islets

Habener, J. F., & Liu, Z. (2014) · Springer eBooks · doi:10.1007/978-94-007-6884-0_13-2 · Cited by 1 · see citing works

THE MECHANISM OF TUMORIGENESIS IN THE IMMORTALIZED HUMAN PANCREATIC CELL LINES: CELL CULTURE MODELS OF HUMAN PANCREATIC CANCER

Chang, Z. (2011) · Digital Commons-TMC (Texas Medical Center)

The Role of Zyxin and LIMD1 in Mitosis and Cancer

Zhou, J. (2019) · DigitalCommons@UNMC

Stem Cell Therapy

Carlson, M. A. (2006)

Wnt Signaling in Pancreatic Islets

Habener, J. F., & Liu, Z. (2014) · Springer eBooks · doi:10.1007/978-94-007-6686-0_13

Faculty Opinions recommendation of Elucidation of a universal size-control mechanism in Drosophila and mammals.

Pan, Z. (2008) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1092090.559724

Activated Pancreatic Stellate Cells Enhance the Warburg Effect to Cause the Malignant Development in Chronic PancreatitisPreprint

Ye, T., Feng, S., Zheng, L., Ming, C., Futao, M., & Qiang, H. (2021) · Research Square · doi:10.21203/rs.3.rs-524181/v1

Pathology Elsewhere

(2005) · Laboratory Investigation · doi:10.1038/labinvest.3700309

Data from Inhibiting the Cyclin-Dependent Kinase CDK5 Blocks Pancreatic Cancer Formation and Progression through the Suppression of Ras-Ral Signaling

Feldmann, G., Mishra, A., Hong, S., Bisht, S., Strock, C. J., Ball, D. W., Goggins, M., Maitra, A., & Nelkin, B. D. (2023) · doi:10.1158/0008-5472.c.6499818.v1

Additional file 3 of The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer

Qian, W., Chen, K., Qin, T., Xiao, Y., Li, J., Yue, Y., Zhou, C., Ma, J., Duan, W., Lei, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13551075

Additional file 4 of The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer

Qian, W., Chen, K., Qin, T., Xiao, Y., Li, J., Yue, Y., Zhou, C., Ma, J., Duan, W., Lei, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13551078

Additional file 2 of The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer

Qian, W., Chen, K., Qin, T., Xiao, Y., Li, J., Yue, Y., Zhou, C., Ma, J., Duan, W., Lei, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13551072

TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stressPreprint

Anand, J. R., Droby, G. N., Joseph, S., Patel, U., Zhang, X., Klomp, J. A., Der, C. J., Purvis, J. E., Wolff, S. C., Bowser, J. L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.26.634889

Additional file 1 of The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer

Qian, W., Chen, K., Qin, T., Xiao, Y., Li, J., Yue, Y., Zhou, C., Ma, J., Duan, W., Lei, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13551069

Proteomics Profiling Identifies MCM4 as a Prognostic Biomarker for Postoperative Metastasis in Solid Pseudopapillary Neoplasms of the Pancreas

He, R., Liu, Y., Dun, R., Ren, S., Tian, W., Gao, H., Shi, Y., Xu, P., Ge, X., Zhang, J., et al. (2026) · Modern Pathology · doi:10.1016/j.modpat.2026.100970

Abstract A32: Notch pathway regulates pancreatic acinar-to-ductal metaplasia

Brodylo, R. L., Lee, M., Lubeseder–Martellato, C., Mazur, P. K., Hampel, F., Zimber-Strobel, U., Strobel, L. J., Schmid, R. M., & Siveke, J. T. (2011) · Cancer Research · doi:10.1158/1538-7445.fbcr11-a32

Acinar-to-ductal metaplasia in pancreatic cancer development

Schmid, R. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15889 · Cited by 48 · see citing works

Acinar cell plasticity and development of pancreatic ductal adenocarcinoma

Störz, P. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.12 · Cited by 388 · see citing works

Abstract C067: Tuft cells transdifferentiate to neural-like progenitor cells in the progression of pancreatic cancer

Salas-Escabillas, D. J., Hoffman, M. T., Brender, S. M., Moore, J. S., Wen, H., Benitz, S., Davis, E. T., Long, D., Wombwell, A., Steele, N. G., et al. (2024) · Cancer Research · doi:10.1158/1538-7445.pancreatic24-c067

Abstract 2206: Uncovering a pancreatic ductal adenocarcinoma sub-population with stemness and unique therapeutic response.

KHAN, S., Chung, W.-C., Moore, C. D., & Xu, K. (2026) · Cancer Research · doi:10.1158/1538-7445.am2026-2206