The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Mitochondrial control of apoptosis: the role of cytochrome c
Open accessAbstract
Mitochondrial cytochrome c (cyt c) has been found to have dual functions in controlling both cellular energetic metabolism and apoptosis. Through interaction with apoptotic protease activating factors (Apaf), cyt c can initiate the activation cascade of caspases once it is released into the cytosol. The loss of a component of the mitochondrial electron transport chain also triggers the generation of superoxide. Although cyt c can be released independent of the mitochondrial permeability transition (MPT), the accompanying cellular redox change can trigger the MPT. Since another apoptotic protease, AIF, is released by MPT, the two separate pathways provide redundancy that ensures effective execution of the cell death program. Anti-apoptotic Bcl-2 family proteins function as gatekeepers to prevent the release of both cyt c and AIF. In spite of their stabilization effect on the mitochondrial outer membrane, Bcl-2 proteins may also be involved in the direct binding of Apaf molecules as regulatory elements further downstream from the mitochondrial apoptotic signals.
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Cites
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Self-citationPrevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
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Self-citationThe Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
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Cited by
Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition
Bernardi, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1127 · Cited by 1,535
Carbon Nanotubes as Intracellular Protein Transporters: Generality and Biological Functionality
Kam, N. W. S., & Dai, H. (2005) · Journal of the American Chemical Society · doi:10.1021/ja050062v · Cited by 1,047
Regulation of superoxide dismutase genes: Implications in disease
Miao, L., & St. Clair, D. K. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.018 · Cited by 912
Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology
Li, J.-M., & Shah, A. M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00124.2004 · Cited by 773
Tarpey, M. M., Wink, D. A., & Grisham, M. B. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00361.2003 · Cited by 673
Metadata
- Authors
- Cai, J., Yang, J., & Jones, D.
- Venue
- Biochimica et Biophysica Acta (BBA) - Bioenergetics
- Publisher
- Elsevier BV
- Published
- 1998-08
- Volume
- 1366
- Issue
- 1-2
- Pages
- 139-149
- ISSN
- 0005-2728 (ISSN-L)
- OpenAlex
- W1987126302
- Cited by
- 768
- References
- 92
- FWCI
- 12.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cai, J., Yang, J., & Jones, D. (1998). Mitochondrial control of apoptosis: the role of cytochrome c. Biochimica et Biophysica Acta (BBA) - Bioenergetics. https://doi.org/10.1016/s0005-2728(98)00109-1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
