Cited by 118Protein Kinase Regulation and GTPase SignalingLipid Membrane Structure and BehaviorPI3K/AKT/mTOR signaling in cancer

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Phospholipid-binding protein domains

Bottomley, M.J., Salim, K., Panayotou, G.·1998·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

DOI 10.1016/s0005-2760(98)00141-6

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Abstract

Research into cellular mechanisms for signal transduction is currently one of the most exciting and rapidly advancing fields of biological study. It has been known for some time that numerous intracellular signals are transmitted by specific protein-protein interactions, as exemplified by those involving the Src homology domains. However, after some controversy, it has recently been widely accepted that specific protein-phospholipid interactions also play key roles in many signal transduction pathways. In this review, landmark discoveries and recent advances describing protein domains known to associate with phospholipids are discussed. Particular emphasis is placed on the interactions of proteins with phospholipids acting as second messengers in signalling pathways. For this purpose, the pleckstrin homology (PH) domain is highlighted, since studies of this domain provided some of the earliest, detailed data about protein-phospholipid interactions occurring downstream of growth factor-mediated receptor stimulation. Moreover, studies of PH domains have given insight into the mechanisms of certain diseases, revealed a number of intriguing functional variations on a common structural theme and recently culminated in providing the missing links in erstwhile mysteries of phosphoinositide-dependent signal transduction pathways. Finally, a short discussion is devoted to the developing field of protein-phospholipid interactions that influence cytoskeletal organisation.

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Authors: Bottomley, M. J., Salim, K., & Panayotou, G.
Affiliations: European Molecular Biology Laboratory (DE)
Ludwig Cancer Research (GB)
Corresponding author: Panayotou, G.
ORCID: Bottomley, M.J.
Panayotou, G.
Venue: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher: Elsevier BV
Published: 1998-12
Volume: 1436
Issue: 1-2
Pages: 165-183
ISSN: 1388-1981 (ISSN-L)
DOI: 10.1016/s0005-2760(98)00141-6
OpenAlex: W1964359053
Cited by: 118
References: 144
Citations by year: 2025: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 1
FWCI: 1.47
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: pleckstrin homology domain, signal transduction, second messengers, cytoskeletal organization, Src homology domains
MeSH terms: Carrier Proteins, Cell Membrane, Inositol Phosphates, Phosphatidylinositols, Phospholipids, Signal Transduction, src Homology Domains

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