Activation of Phospholipase C-γ by Phosphatidylinositol 3,4,5-Trisphosphate

Inositol trisphosphate and calcium signalling

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Oncogenes and signal transduction

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

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Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3‐OH kinase and protein kinase B/Akt cellular survival pathway

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Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

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Regulation of Phosphoinositide-specific Phospholipase C Isozymes

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Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB

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Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase

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Phosphatidylinositol 3‐kinase

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A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits

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Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

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Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

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Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate

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Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors

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Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins

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Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland

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Polyphosphoinositides Produced by Phosphatidylinositol 3-Kinase Are Poor Substrates for Phospholipases C from Rat Liver and Bovine Brain

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The regulation of phospholipase C-gamma 1 by phosphatidic acid. Assessment of kinetic parameters.

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Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.

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Activation of Phospholipase C-γ by the Concerted Action of Tau Proteins and Arachidonic Acid

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A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol

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Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking.

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Observation of inositol pentakis- and hexakis-phosphates in mammalian tissues by 31P NMR

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Characterization of a Soluble Adrenal Phosphatidylinositol 4-Kinase Reveals Wortmannin Sensitivity of Type III Phosphatidylinositol Kinases

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Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil

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The yeast and mammalian isoforms of phosphatidylinositol transfer protein can all restore phospholipase C-mediated inositol lipid signaling in cytosol-depleted RBL-2H3 and HL-60 cells.

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The haemopoietic growth factors interleukin 3 and colony stimulating factor‐1 stimulate proliferation but do not induce inositol lipid breakdown in murine bone‐marrow‐derived macrophages.

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Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains.

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Inhibition of agonist-stimulated inositol 1,4,5-trisphosphate production and calcium signaling by the myosin light chain kinase inhibitor, wortmannin.

Nakanishi, S., Catt, K. J., & Balla, T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37404-5 · Cited by 58 · see citing works

Structure and function of phosphatidylinositol 3-kinase: a potential second messenger system involved in growth control

Fry, M., & Waterfield, M. D. (1993) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1993.0076 · Cited by 45 · see citing works

Synthesis of the D-3 Series of Phosphatidylinositol Phosphates

Wang, D.-S., & Chen, C. (1996) · The Journal of Organic Chemistry · doi:10.1021/jo960602u · Cited by 43 · see citing works

Mammalian Phospholipase C

Kadamur, G., & Ross, E. M. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183750 · Cited by 529 · see citing works

The Phospholipase C Isozymes and Their Regulation

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Regulation of phospholipase C γ isoforms in haematopoietic cells

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Four Tyrosine Residues in Phospholipase C-γ2, Identified as Btk-dependent Phosphorylation Sites, Are Required for B Cell Antigen Receptor-coupled Calcium Signaling

Watanabe, D., Hashimoto, S., Ishiai, M., Matsushita, M., Baba, Y., Kishimoto, T., Kurosaki, T., & Tsukada, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103675200 · Cited by 136 · see citing works

Phospholipid-binding protein domains

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TNF-α Stimulation of MCP-1 Expression Is Mediated by the Akt/PKB Signal Transduction Pathway in Vascular Endothelial Cells

Murao, K., Ohyama, T., Imachi, H., Ishida, T., Cao, W. M., Namihira, H., Sato, M., Wong, N. C. W., & Takahara, J. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3497 · Cited by 99 · see citing works

Isozyme-specific stimulation of phospholipase C-γ2 by Rac GTPases

Piechulek, T., Rehlen, T., Walliser, C., Vatter, P., Moepps, B., & Gierschik, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509396200 · Cited by 80 · see citing works

Peptidoglycan and lipopolysaccharide activate PLCγ2, leading to enhanced cytokine production in macrophages and dendritic cells

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Activation of Phospholipase Cγ2 by Tyrosine Phosphorylation

Özdener, F., Dangelmaier, C., Ashby, B., Kunapuli, S. P., & Daniel, J. L. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.3.672 · Cited by 60 · see citing works

INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model

Iguchi, A., Takatori, S., Kimura, S., Muneto, H., Wang, K., Etani, H., Ito, G., Sato, H., Hori, Y., Sasaki, J., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106375 · Cited by 37 · see citing works

Rapid and transient thrombin stimulation of phosphatidylinositol 4,5‐bisphosphate synthesis but not of phosphatidylinositol 3,4‐bisphosphate independent of phospholipase C activation in platelets

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The Thrombin-induced Hydrolysis of Phosphatidylinositol: the Work of Philip W. Majerus

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The lipid transfer activity of phosphatidylinositol transfer protein is sufficient to account for enhanced phospholipase C activity in turkey erythrocyte ghosts

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Phospholipase C from human melanoma: purification and characterization of a phosphatidylinositol-selective enzyme

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The Presence of Ca2+-Independent Phospholipase-A1 Highly Specific for Phosphatidylinositol in Bovine Brain

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