Cited by 151S100 Proteins and AnnexinsAdvanced Glycation End Products researchCancer Mechanisms and Therapy

Expression analysis of S100 proteins and RAGE in human tumors using tissue microarrays

Hsieh, Hsiao-Ling, Schäfer, Beat W., Sasaki, Nobuyuki, Heizmann, Claus W.·2003·Biochemical and Biophysical Research Communications

Abstract

Microarray technology provides important information for diagnostic, prognostic, and even therapeutic applications. Several S100 proteins have been proposed to play important roles in tumor progression and are recognized as potential tumor markers. To substantiate these limited earlier findings, we screened hundreds of tumor specimens from patients of eight different tumor types using tissue microarrays. The results validated the expression of S100A4, S100A6, and S100B in specific tumor types. A significant S100A2 expression was observed in lymphoma biopsies, which implies a possible link between this S100 protein and lymphoma development. In contrast, S100A5 and S100A12 were not significantly expressed in any of the tumor tissues tested. Interestingly, expression of RAGE (receptor for advanced glycation end products) was found in breast and lung tumor tissues where abundant S100A4 and S100A6 expression was also observed. This suggests a possible role of RAGE-mediated signal transduction in the development of these particular cancers.

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Crossref · 10.1016/s0006-291x(03)01190-2

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Authors
Hsieh, H.-L., Schäfer, B. W., Sasaki, N., & Heizmann, C. W.
Affiliations
  • University of Zurich (CH)
  • Sapporo Medical University (JP)
Corresponding author
Heizmann, Claus W.
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2003-07
Volume
307
Issue
2
Pages
375-381
ISSN
0006-291X (ISSN-L)
OpenAlex
W2084898158
Cited by
151
References
47
Citations by year
2025: 4 · 2024: 5 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 4 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 10 · 2012: 7
FWCI
3.58
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cancer Mechanisms and Therapy
Keywords
S-100 protein, S100A4, S100A6, S100B, S100A2, RAGE, receptor for advanced glycation end products, tumor markers, lymphoma, breast cancer, lung cancer, tumor progression, signal transduction
MeSH terms
Receptor for Advanced Glycation End Products, Animals, Humans, Neoplasm Proteins, Neoplasms, S100 Proteins, Receptors, Immunologic, Tumor Cells, Cultured, Signal Transduction, Gene Expression Regulation, Neoplastic, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling

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