Expression analysis of S100 proteins and RAGE in human tumors using tissue microarrays
Abstract
Microarray technology provides important information for diagnostic, prognostic, and even therapeutic applications. Several S100 proteins have been proposed to play important roles in tumor progression and are recognized as potential tumor markers. To substantiate these limited earlier findings, we screened hundreds of tumor specimens from patients of eight different tumor types using tissue microarrays. The results validated the expression of S100A4, S100A6, and S100B in specific tumor types. A significant S100A2 expression was observed in lymphoma biopsies, which implies a possible link between this S100 protein and lymphoma development. In contrast, S100A5 and S100A12 were not significantly expressed in any of the tumor tissues tested. Interestingly, expression of RAGE (receptor for advanced glycation end products) was found in breast and lung tumor tissues where abundant S100A4 and S100A6 expression was also observed. This suggests a possible role of RAGE-mediated signal transduction in the development of these particular cancers.
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Both TLR4 and RAGE are expressed in breast cancer cells.
“Both TLR4 and RAGE are expressed in breast cancer cells (Bos et al., 2009; Hsieh et al., 2003).”
From A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis (2012) · cites this paper as Hsieh et al., 2003
Cites
Tissue microarrays for high-throughput molecular profiling of tumor specimens
Kononen, J., Bubendorf, L., Kallionimeni, A., Barlund, M. T., Schraml, P., Leighton, S. B., Torhorst, J. K. H., Mihatsch, M. J., Sauter, G., & Kallionimeni, O.-P. (1998) · Nature Medicine · doi:10.1038/nm0798-844 · Cited by 4,101 · see citing works
RAGE Mediates a Novel Proinflammatory Axis
Hofmann, M. A., Drury, S., Fu, C., Qu, W., Taguchi, A., Lu, Y., Avila, C., Kambham, N., Bierhaus, A., Nawroth, P., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80801-6 · Cited by 1,864 · see citing works
Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases
Taguchi, A., Blood, D. C., del Toro, G., Canet, A., Lee, D. C., Qu, W., Tanji, N., Lu, Y., Lalla, E., Fu, C., et al. (2000) · Nature · doi:10.1038/35012626 · Cited by 1,217 · see citing works
Park, L., Raman, K. G., Lee, K. J., Lu, Y., Ferran, L. J., Chow, W. S., Stern, D. M., & Schmidt, A. M. (1998) · Nature Medicine · doi:10.1038/2012 · Cited by 1,103 · see citing works
Validation of Tissue Microarray Technology in Breast Carcinoma
Camp, R. L., Charette, L. A., & Rimm, D. L. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780204 · Cited by 811 · see citing works
S100 proteins structure functions and pathology
Heizmann, C. W. (2002) · Frontiers in bioscience · doi:10.2741/a846 · Cited by 706 · see citing works
Self-citationThe Nucleobase‐Cation‐Symport‐1 Family of Membrane Transport Proteins
Weyand, S. N., Ma, P., Saidijam, M., Baldwin, J. M., Beckstein, O., Jackson, S. M., Suzuki, S., Patching, S. G., Shimamura, T., Sansom, M. S. P., et al. (2004) · Handbook of Metalloproteins · doi:10.1002/0470028637.met268 · Cited by 619 · see citing works
Huttunen, H. J., Kuja‐Panula, J., Sorci, G., Agneletti, A. L., Donato, R., & Rauvala, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006993200 · Cited by 578 · see citing works
S100 proteins: structure, functions and pathology
Claus, W. H. (2002) · Frontiers in bioscience · doi:10.2741/heizmann · Cited by 413 · see citing works
Schäfer, B. W., Wicki, R., Engelkamp, D., et al. (1995) · Genomics · doi:10.1016/0888-7543(95)80005-7 · Cited by 332 · see citing works
Self-citationBucciarelli, L. G., Wendt, T., Rong, L., Lalla, E., Hofmann, M. A., Goova, M. T., Taguchi, A., Yan, S. F., Yan, S. D., Stern, D. M., et al. (2002) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-002-8491-x · Cited by 304 · see citing works
(2002) · PubMed · Cited by 292 · see citing works
Prognostic significance of the metastasis-inducing protein S100A4 (p9Ka) in human breast cancer.
Rudland, P. S., Platt-Higgins, A. M., Renshaw, C., West, C. R., Winstanley, J. H., Robertson, L. B., & Barraclough, R. (2000) · PubMed · Cited by 278 · see citing works
Tissue Microarray Profiling of Cancer Specimens and Cell Lines: Opportunities and Limitations
Hoos, A., & Cordon‐Cardo, C. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780347 · Cited by 275 · see citing works
Sasaki, N., Toki, S., Chowei, H., Saito, T., Nakano, N., Hayashi, Y., Takeuchi, M., & Makita, Z. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03075-4 · Cited by 253 · see citing works
Self-citationProinflammatory properties of the human S100 protein S100A12
Yang, Z., Tao, T., Raftery, M. J., et al. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.6.986 · Cited by 234 · see citing works
Giri, R., Shen, Y., Stins, M., Du Yan, S., Schmidt, A. M., Stern, D., Kim, K.-S., Zlokovic, B., & Kalra, V. K. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.6.c1772 · Cited by 218 · see citing works
Bjørnland, K., Winberg, J. O., Ødegaard, O. T., et al. (1999) · PubMed · Cited by 170 · see citing works
Yao, J., Xiong, S., Klos, K. S., Nguyen, N. T., Grijalva, R., Li, P., & Yu, D. (2001) · Oncogene · doi:10.1038/sj.onc.1204944 · Cited by 168 · see citing works
Protein S100A4: Too Long Overlooked by Pathologists?
Mazzucchelli, L. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64342-8 · Cited by 154 · see citing works
Carnemolla, B., Neri, D., Castellani, P., Leprini, A., Neri, G., Pini, A., Winter, G. P., & Zardi, L. (1996) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19961104)68:3 · Cited by 147 · see citing works
Calcium-binding protein S100A4 in health and disease
Barraclough, R. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(98)00143-8 · Cited by 141 · see citing works
BÖNI, R., Burg, G., Doguoglu, A., Ilg, E. C., Schäfer, B. W., Müller, B. P., & Heizmann, C. W. (1997) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1997.17651853.x · Cited by 131 · see citing works
Self-citationHauschild, Engel, Brenner, W., et al. (1999) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1999.02905.x · Cited by 122 · see citing works
Brun, J. G., Jonsson, R., & Haga, H. J. (1994) · PubMed · Cited by 121 · see citing works
Davies, B. R., O’Donnell, M., Durkan, G. C., et al. (2002) · The Journal of Pathology · doi:10.1002/path.1051 · Cited by 118 · see citing works
Camby, I., Nagy, N., Lopes, M.-B. S., et al. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00205.x · Cited by 112 · see citing works
van de Vaart, P. J. M., Belderbos, J. S. A., de Jong, D., Sneeuw, K. C. A., Majoor, D. M., Bartelink, H. G. M. M., & Begg, A. C. (2000) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(20000320)89:2 · Cited by 102 · see citing works
Quantitative cell dispersion analysis: New test to measure tumor cell aggressiveness
Nawrocki‐Raby, B., Polette, M., Gilles, C., et al. (2001) · International Journal of Cancer · doi:10.1002/ijc.1380 · Cited by 101 · see citing works
Increased expression of S100A4 and its prognostic significance in esophageal squamous cell carcinoma
Ninomiya, I., Ohta, T., FUSHIDA, S., et al. (2001) · International Journal of Oncology · doi:10.3892/ijo.18.4.715 · Cited by 100 · see citing works
Psoriasin interacts with Jab1 and influences breast cancer progression.
Emberley, E. D., Niu, Y., Leygue, E., Tomes, L., Gietz, R. D., Murphy, L. C., & Watson, P. H. (2003) · PubMed · Cited by 97 · see citing works
Relation between aberrant α-catenin expression and loss of E-cadherin function in prostate cancer
Umbas, R., Isaacs, W. B., Bringuier, P. P., Xue, Y., Debruyne, F. M. J., & Schalken, J. A. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970822)74:4 · Cited by 92 · see citing works
S100A2, a Putative Tumor Suppressor Gene, Regulates In Vitro Squamous Cell Carcinoma Migration
Nagy, N., Brenner, C., Markadieu, N., et al. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780269 · Cited by 91 · see citing works
Komatsu, K., Kobune-Fujiwara, Y., Andoh, A., Ishiguro, S., Hunai, H., Suzuki, N., Kameyama, M., Murata, K., Miyoshi, J., Akedo, H., et al. (2000) · British Journal of Cancer · doi:10.1054/bjoc.2000.1356 · Cited by 87 · see citing works
Lakshmi, M. S., Parker, C., & Sherbet, G. V. (1993) · PubMed · Cited by 85 · see citing works
Taylor, S., Herrington, C. S., Prime, W., Rudland, P. S., & Barraclough, R. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600071 · Cited by 75 · see citing works
Scheler, C., Li, X., Salnikow, J., Dunn, M. J., & Jungblut, P. R. (1999) · Electrophoresis · doi:10.1002/(sici)1522-2683(19991201)20:18 · Cited by 72 · see citing works
BÖNI, R., Burg, G., Doguoglu, A., et al. (1997) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1997.tb03698.x · Cited by 67 · see citing works
Komatsu, K., Murata, K., Kameyama, M., Ayaki, M., Mukai, M., Ishiguro, S., Miyoshi, J., Tatsuta, M., Inoue, M., & Nakamura, H. (2002) · Oncology · doi:10.1159/000063812 · Cited by 64 · see citing works
S100A1, a New Marker for Acute Myocardial Ischemia
Kiewitz, R., Acklin, C., Minder, E. I., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3229 · Cited by 62 · see citing works
van Ginkel, P. R., Gee, R. L., Walker, T. M., Hu, D., Heizmann, C. W., & Polans, A. S. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(98)00133-5 · Cited by 62 · see citing works
Self-citationYu, W. H., & Fraser, P. E. (2001) · PubMed Central · doi:10.1523/jneurosci.21-07-02240.2001 · Cited by 55 · see citing works
Bronckart, Y., Decaestecker, C., Nagy, N., et al. (2001) · PubMed · doi:10.14670/hh-16.707 · Cited by 46 · see citing works
Parker, C., Lakshmi, M. S., Piura, B., & Sherbet, G. V. (1994) · DNA and Cell Biology · doi:10.1089/dna.1994.13.343 · Cited by 45 · see citing works
3 D Structures of the Calcium and Zinc Binding S 100 Proteins
Fritz, G., & Heizmann, C. W. (2004) · Encyclopedia of Inorganic and Bioinorganic Chemistry · doi:10.1002/9781119951438.eibc0511 · Cited by 36 · see citing works
Self-citationKayser, K., André, S., Nv, B., et al. (1997) · PubMed · Cited by 15 · see citing works
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- Authors
- Hsieh, H.-L., Schäfer, B. W., Sasaki, N., & Heizmann, C. W.
- Affiliations
- University of Zurich (CH)
- Sapporo Medical University (JP)
- Corresponding author
- Heizmann, Claus W.
- ORCID
- Schäfer, Beat W.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2003-07
- Volume
- 307
- Issue
- 2
- Pages
- 375-381
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2084898158
- Cited by
- 151
- References
- 47
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 4 · 2017: 5 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 10 · 2012: 7
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cancer Mechanisms and Therapy
- Keywords
- S-100 protein, S100A4, S100A6, S100B, S100A2, RAGE, receptor for advanced glycation end products, tumor markers, lymphoma, breast cancer, lung cancer, tumor progression, signal transduction
- MeSH terms
- Receptor for Advanced Glycation End Products, Animals, Humans, Neoplasm Proteins, Neoplasms, S100 Proteins, Receptors, Immunologic, Tumor Cells, Cultured, Signal Transduction, Gene Expression Regulation, Neoplastic, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling
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