The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Coping with stress: calmodulin and calcineurin in model and pathogenic fungi
Abstract
Calcium signaling via calmodulin and calcineurin is critical for the regulation of stress responses in fungi. The functions of calmodulin and calcineurin are largely conserved among pathogenic fungi and model fungi, however, the mechanisms of action have diverged. Saccharomyces cerevisiae is an excellent model for understanding the framework of calcium-mediated signal transduction pathways, and considerable progress has been made in understanding the details of how Ca(2+)-calmodulin and calcineurin control adaptation to environmental stress. Studies using the divergent human pathogenic fungi Candida albicans and Cryptococcus neoformans reveal that calcineurin is critical for virulence, yet it acts via distinct mechanisms in each fungus. These differences in function may reflect the requirements of each pathogen to survive inside the host, and illustrate that studies must be conducted in each organism in order to elucidate the details of the molecular mechanisms of calmodulin and calcineurin-mediated signaling pathways.
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In the citing paper
“Calcineurin is a heterodimer consisting of a catalytic A subunit and a Ca2+-binding regulatory B subunit, and the association between the two subunits is necessary for phosphatase activity (19).”
From Roles of Calcineurin and Crz1 in Antifungal Susceptibility and Virulence of Candida glabrata (2010) · cites this paper as [19]
In the citing paper
“The characterization of this enzyme in genetically tractable yeasts has revealed a major role for calcineurin in fungi as mediator of responses to environmental stress conditions that compromise cell viability (reviewed in Kraus and Heitman 2003;Cyert 2003;Sugiura et al. 2002).”
From Functional characterization of the Candida albicans CRZ1 gene encoding a calcineurin-regulated transcription factor (2005) · cites this paper as Kraus and Heitman 2003
Citations
Cites
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Calmodulin: a prototypical calcium sensor
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Crystal structures of human calcineurin and the human FKBP12–FK506–calcineurin complex
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Calcium-induced conformational transition revealed by the solution structure of apo calmodulin
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Calcineurin is required for virulence of Cryptococcus neoformans
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da Silva Ferreira, M. E., Kress, M. R. V. Z., Savoldi, M., Goldman, M. H. S., Härtl, A., Heinekamp, T., Brakhage, A. A., & Goldman, G. H. (2006) · Eukaryotic Cell · doi:10.1128/ec.5.1.207-211.2006 · Cited by 403
Rispail, N., Soanes, D. M., Ant, C., Czajkowski, R., Grünler, A., Huguet, R., Pérez‐Nadales, E., Poli, A., Sartorel, E., Valiante, V., et al. (2009) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2009.01.002 · Cited by 312
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Metadata
- Authors
- Kraus, P. R., & Heitman, J.
- Affiliations
- Duke Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Heitman, Joseph
- ORCID
- Heitman, Joseph
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 311
- Issue
- 4
- Pages
- 1151-1157
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2066800858
- Cited by
- 169
- References
- 66
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 21 · 2013: 6 · 2012: 12
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- calmodulin, calcineurin, calcium signaling, stress response, fungal virulence, Candida albicans, Cryptococcus neoformans, Saccharomyces cerevisiae, environmental stress adaptation, fungal pathogens
- MeSH terms
- Calmodulin, Candida albicans, Cryptococcus neoformans, Fungi, Saccharomyces cerevisiae, Species Specificity, Transcriptional Activation, Gene Expression Regulation, Fungal, Calcineurin, Calcium Signaling
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