Cited by 169Fungal and yeast genetics researchSignaling Pathways in DiseaseFungal Infections and Studies

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Coping with stress: calmodulin and calcineurin in model and pathogenic fungi

Kraus, Peter R, Heitman, Joseph·2003·Biochemical and Biophysical Research Communications

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Abstract

Calcium signaling via calmodulin and calcineurin is critical for the regulation of stress responses in fungi. The functions of calmodulin and calcineurin are largely conserved among pathogenic fungi and model fungi, however, the mechanisms of action have diverged. Saccharomyces cerevisiae is an excellent model for understanding the framework of calcium-mediated signal transduction pathways, and considerable progress has been made in understanding the details of how Ca(2+)-calmodulin and calcineurin control adaptation to environmental stress. Studies using the divergent human pathogenic fungi Candida albicans and Cryptococcus neoformans reveal that calcineurin is critical for virulence, yet it acts via distinct mechanisms in each fungus. These differences in function may reflect the requirements of each pathogen to survive inside the host, and illustrate that studies must be conducted in each organism in order to elucidate the details of the molecular mechanisms of calmodulin and calcineurin-mediated signaling pathways.

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Authors: Kraus, P. R., & Heitman, J.
Affiliations: Duke Medical Center (US)
Howard Hughes Medical Institute (US)
Corresponding author: Heitman, Joseph
ORCID: Heitman, Joseph
Venue: Biochemical and Biophysical Research Communications
Publisher: Elsevier BV
Published: 2003-11
Volume: 311
Issue: 4
Pages: 1151-1157
ISSN: 0006-291X (ISSN-L)
DOI: 10.1016/s0006-291x(03)01528-6
OpenAlex: W2066800858
Cited by: 169
References: 66
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 21 · 2013: 6 · 2012: 12
FWCI: 3.00
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochemical and Biophysical Research Communications (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords: calmodulin, calcineurin, calcium signaling, stress response, fungal virulence, Candida albicans, Cryptococcus neoformans, Saccharomyces cerevisiae, environmental stress adaptation, fungal pathogens
MeSH terms: Calmodulin, Candida albicans, Cryptococcus neoformans, Fungi, Saccharomyces cerevisiae, Species Specificity, Transcriptional Activation, Gene Expression Regulation, Fungal, Calcineurin, Calcium Signaling

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Coping with stress: calmodulin and calcineurin in model and pathogenic fungi

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