The actions of arginine and glucose on glucagon secretion are mediated by opposite effects on cytoplasmic Ca2+
Abstract
Cytoplasmic Ca2+ (Ca2+i) was monitored in single guinea-pig pancreatic alpha 2-cells exposed to modulators of glucagon release. The stimulatory amino acid arginine raised Ca2+i from 62 to 160 nM, whereas the inhibitor glucose reduced both the latter concentration and basal Ca2+i by 30%. Epinephrine which potentiates arginine-stimulated secretion by increasing cAMP, does so without affecting Ca2+i. The results indicate that glucagon secretion is positively modulated by Ca2+i. It is suggested that glucose-induced lowering of Ca2+i is a fundamental effect in cells where the sugar is readily metabolized.
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These data are consistent with stimulated sequestration and outward transport of Ca2+ being saturated at lower glucose concentrations in alpha-cells than in beta-cells.
“These data are consistent with stimulated sequestration and outward transport of Ca 2ϩ (14,20,21) being saturated at lower glucose concentrations in ␣-cells (14) than in -cells (21).”
From Paradoxical Stimulation of Glucagon Secretion by High Glucose Concentrations (2006) · cites this paper as [20]
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Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells
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- Authors
- Johansson, H., Gylfe, E., & Hellman, B.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Gylfe, Erik
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1987-08
- Volume
- 147
- Issue
- 1
- Pages
- 309-314
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2020726723
- Cited by
- 51
- References
- 18
- Citations by year
- 2023: 1 · 2021: 2 · 2018: 1 · 2015: 1 · 2012: 2
- FWCI
- 7.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medicinska Forskningsrådet (12x-562, 12x-6240)
- Stiftelsen Familjen Ernfors Fond
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- glucagon secretion, L-arginine, glucose, intracellular calcium, alpha cells, epinephrine, cyclic AMP, calcium signaling
- MeSH terms
- Animals, Arginine, Calcium, Cytoplasm, Epinephrine, Glucagon, Glucose, Guinea Pigs, Islets of Langerhans, In Vitro Techniques
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