The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
ahr null alleles: distinctive or different?
Abstract
Two independent laboratories have generated Ahr "null" or "knockout" mice that share some common characteristics but also have distinct phenotypes. In this Commentary, we will discuss our view of the candidate variables that might account for these differences. More importantly, we hope that this discussion can identify important parameters to be assessed by investigators in the process of characterizing their own modified loci. The variables that we have considered include the possibility that different targeting strategies can result in altered products with unsuspected function or that the targeting event itself can alter the function of neighboring genes. Further, genetic background can have an important influence on phenotype, and differences in genome can be introduced during derivation by the type of embryonic stem cells used and by the random segregation of parental genes in the F2 generation of line propagation. In addition, phenotype may be acutely sensitive to environmental variables, such as pathogen and chemical exposure and stress introduced by crowding and disease. Finally, we discuss approaches to resolving differences between null mice and propose a partial solution, the institution of a repository for detailed information on targeted alleles that may not typically be allowed in today's "fast paced" scientific publications.
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“Despite inconsistent reports in initial characterization of these three models, subsequent examination of these alleles has indicated that all phenotypes are in fact quite similar and the variation is due to genetic background, environmental variables, or distinct laboratory emphasis (Lahvis & Bradfield, 1998).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Lahvis & Bradfield, 1998
Citations
Cites
Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype
Threadgill, D. W., Dlugosz, A. A., Hansen, L. A., Tennenbaum, T., Lichti, U., Yee, D., LaMantia, C., Mourton, T., Herrup, K., Harris, R. C., et al. (1995) · Science · doi:10.1126/science.7618084 · Cited by 1,179
Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin-Binding Ah Receptor
Fernandez-Salguero, P., Pineau, T., Hilbert, D. M., McPhail, T., Lee, S. S. T., Kimura, S., Nebert, D. W., Rudikoff, S., Ward, J. M., & Gonzalez, F. J. (1995) · Science · doi:10.1126/science.7732381 · Cited by 1,075
Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor
Sibilia, M., & Wagner, E. F. (1995) · Science · doi:10.1126/science.7618085 · Cited by 1,002
Schmidt, J. V., Su, G. H., Reddy, J. K., Simon, M. C., & Bradfield, C. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6731 · Cited by 902
Self-citationFernández‐Salguero, P. M., Hilbert, D. M., Rudikoff, S., Ward, J. M., & Gonzalez, F. J. (1996) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.0210 · Cited by 835
Mouse genetics: concepts and applications
(1995) · Choice Reviews Online · doi:10.5860/choice.33-2135 · Cited by 757
Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice
Simpson, E. M., Linder, C. C., Sargent, E. E., Davisson, M. T., Mobraaten, L. E., & Sharp, J. J. (1997) · Nature Genetics · doi:10.1038/ng0597-19 · Cited by 684
Know Your Neighbors: Three Phenotypes in Null Mutants of the Myogenic bHLH Gene MRF4
Olson, E. N., Arnold, H.-H., Rigby, P. W. J., & Wold, B. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81073-9 · Cited by 577
Poland, A., & Glover, E. A. (1977) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)12455-3 · Cited by 353
Tumour promotion by TCDD in skin of HRS/J hairless mice
Poland, A., Palen, D., & Glover, E. A. (1982) · Nature · doi:10.1038/300271a0 · Cited by 294
Research works printed but not linked: 1
- Poland, 1977, Chlorinated biphenyl induction of aryl hydrocarbon hydroxylase activity, Mol Pharmacol, 13, 924
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The PAS Superfamily: Sensors of Environmental and Developmental Signals
Gu, Y.-Z., Hogenesch, J. B., & Bradfield, C. A. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.519 · Cited by 1,044
Self-citationExogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation
Li, Y., Innocentin, S., Withers, D. R., Roberts, N. A., Gallagher, A., Grigorieva, E. F., Wilhelm, C., & Veldhoen, M. (2011) · Cell · doi:10.1016/j.cell.2011.09.025 · Cited by 837
The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor
Nguyen, L. P., & Bradfield, C. A. (2007) · Chemical Research in Toxicology · doi:10.1021/tx7001965 · Cited by 718
Self-citationAhR signaling pathways and regulatory functions
Larigot, L., Juricek, L., Dairou, J., & Coumoul, X. (2018) · Biochimie Open · doi:10.1016/j.biopen.2018.05.001 · Cited by 563
Ligand binding and activation of the Ah receptor
Denison, M. S., Pandini, A., Nagy, S. R., Baldwin, E. P., & Bonati, L. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00063-7 · Cited by 485
Metadata
- Authors
- Lahvis, G. P., & Bradfield, C. A.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Bradfield, Christopher A
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 56
- Issue
- 7
- Pages
- 781-787
- ISSN
- 0006-2952 (ISSN-L)
- OpenAlex
- W2131562982
- Cited by
- 152
- References
- 25
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 8 · 2015: 2 · 2014: 5 · 2013: 8 · 2012: 9
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p30ca007175-36)
- National Cancer Institute (P30 CA 07175)
- National Institute of Environmental Health Sciences (ES06883, R01ES006883)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Keywords
- aryl hydrocarbon receptor, knockout mice, genetic background effects, embryonic stem cell derivation, phenotypic variability
- MeSH terms
- Alleles, Animals, Crosses, Genetic, Models, Biological, Pedigree, Phenotype, Receptors, Aryl Hydrocarbon, Mice, Knockout, Mice
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