The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Dopamine D2 receptor availability and amphetamine-induced dopamine release in unipolar depression
Abstract
Background Reduced dopaminergic transmission has been implicated in the pathophysiology of major depression. The aim of the present study was to measure striatal D(2) receptor availability and amphetamine-induced dopamine release in nonpsychotic, unmedicated, unipolar patients during an episode of major depression.Methods The striatal equilibrium specific to nonspecific partition coefficient (V(3)") of the D(2) receptor antagonist [(123)I]IBZM was measured with single photon emission computerized tomography before and after amphetamine administration in 9 depressed subjects and 10 matched healthy control subjects.Results No significant differences were observed in preamphetamine D(2) receptor availability between depressed patients (0.73 +/- 0.08) and control subjects (0.78 +/- 0.10, p =.23). Amphetamine-induced reduction in [(123)I]IBZM V(3)" (DeltaV(3)") was similar in depressed patients (-9.8 +/- 5.5%) and control subjects (-7.8 +/- 2.5%, p =.32). Amphetamine induced a transient improvement in symptomatology in depressed patients, but this improvement did not correlate with [(123)I]IBZM DeltaV(3)".Conclusions This study did not replicate previously reported alterations in striatal D(2) receptor density in depressed patients and suggests that stimulant-induced dopamine release is not altered in major depression.
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“These studies have indicated increased D2 receptor binding in the basal ganglia [257], striatum [258,259], and putamen [260], whereas other studies have reported lower [261] or no difference [259,262,263] in striatal D2 transporter binding potential.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [259]
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Metadata
- Authors
- Parsey, R. V., Oquendo, M. A., Zea-Ponce, Y., Rodenhiser, J., Kegeles, L. S., Pratap, M., Cooper, T. B., Van Heertum, R., Mann, J. J., & Laruelle, M.
- Affiliations
- Columbia University (US)
- New York State Psychiatric Institute (US)
- Columbia University Irving Medical Center (US)
- Corresponding author
- Parsey, Ramin V
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2001-09
- Volume
- 50
- Issue
- 5
- Pages
- 313-322
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1976435745
- Cited by
- 133
- References
- 50
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 9
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (1K02 MH01603-01, P30MH046745, 2 P30 MH46745-10, K02MH001603)
- National Center for Research Resources (M01RR000645)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- amphetamine-induced dopamine release, major depressive disorder, striatum, [123I]IBZM, dopamine transporter imaging, dopamine signaling
- MeSH terms
- Adolescent, Adult, Amphetamine, Benzamides, Corpus Striatum, Major Depressive Disorder, Dopamine, Female, Humans, Iodine Radioisotopes, Male, Middle Aged, Synaptic Transmission, Pyrrolidines, Tomography, Emission-Computed, Single-Photon, Receptors, Dopamine D2
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