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Cited by 133Neurotransmitter Receptor Influence on BehaviorTreatment of Major DepressionTryptophan and brain disorders

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Dopamine D2 receptor availability and amphetamine-induced dopamine release in unipolar depression

Parsey, Ramin V, Oquendo, Maria A, Zea-Ponce, Yolanda, Rodenhiser, Janine, Kegeles, Lawrence S, Pratap, Mali, Cooper, Thomas B, Van Heertum, Ronald, Mann, J.John, Laruelle, Marc·2001·Biological Psychiatry
DOI 10.1016/s0006-3223(01)01089-7
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Abstract

Background Reduced dopaminergic transmission has been implicated in the pathophysiology of major depression. The aim of the present study was to measure striatal D(2) receptor availability and amphetamine-induced dopamine release in nonpsychotic, unmedicated, unipolar patients during an episode of major depression.Methods The striatal equilibrium specific to nonspecific partition coefficient (V(3)") of the D(2) receptor antagonist [(123)I]IBZM was measured with single photon emission computerized tomography before and after amphetamine administration in 9 depressed subjects and 10 matched healthy control subjects.Results No significant differences were observed in preamphetamine D(2) receptor availability between depressed patients (0.73 +/- 0.08) and control subjects (0.78 +/- 0.10, p =.23). Amphetamine-induced reduction in [(123)I]IBZM V(3)" (DeltaV(3)") was similar in depressed patients (-9.8 +/- 5.5%) and control subjects (-7.8 +/- 2.5%, p =.32). Amphetamine induced a transient improvement in symptomatology in depressed patients, but this improvement did not correlate with [(123)I]IBZM DeltaV(3)".Conclusions This study did not replicate previously reported alterations in striatal D(2) receptor density in depressed patients and suggests that stimulant-induced dopamine release is not altered in major depression.

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Research works printed but not linked: 2

  1. Laruelle, 1994, Compartmental modeling of iodine-123-iodobenzofuran binding to dopamine D2 receptors in healthy subjects, J Nucl Med, 35, 743
  2. Malison, 1999, Reduced amphetamine-stimulated dopamine release in cocaine addicts as measured by [123I]IBZM SPECT, J Nucl Med, 40, 110P

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Metadata

Authors
Parsey, R. V., Oquendo, M. A., Zea-Ponce, Y., Rodenhiser, J., Kegeles, L. S., Pratap, M., Cooper, T. B., Van Heertum, R., Mann, J. J., & Laruelle, M.
Affiliations
  • Columbia University (US)
  • New York State Psychiatric Institute (US)
  • Columbia University Irving Medical Center (US)
Corresponding author
Parsey, Ramin V
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2001-09
Volume
50
Issue
5
Pages
313-322
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(01)01089-7
OpenAlex
W1976435745
Cited by
133
References
50
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 9
FWCI
2.94
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (1K02 MH01603-01, P30MH046745, 2 P30 MH46745-10, K02MH001603)
  • National Center for Research Resources (M01RR000645)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
amphetamine-induced dopamine release, major depressive disorder, striatum, [123I]IBZM, dopamine transporter imaging, dopamine signaling
MeSH terms
Adolescent, Adult, Amphetamine, Benzamides, Corpus Striatum, Major Depressive Disorder, Dopamine, Female, Humans, Iodine Radioisotopes, Male, Middle Aged, Synaptic Transmission, Pyrrolidines, Tomography, Emission-Computed, Single-Photon, Receptors, Dopamine D2

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