Neuropeptide-Y, cortisol, and subjective distress in humans exposed to acute stress: replication and extension of previous report
Abstract
Background We previously reported that stress-related release of cortisol and neuropeptide-Y (NPY) were significantly and positively associated in U.S. Army soldiers participating in survival training. Furthermore, greater levels of NPY were observed in individuals exhibiting fewer psychologic symptoms of dissociation during stress. This study tested whether these findings would be replicated in a sample of U.S. Navy personnel participating in survival school training.Methods Psychologic as well as salivary and plasma hormone indices were assessed in 25 active duty personnel before, during, and 24 hours after exposure to U.S. Navy survival school stress.Results Cortisol and NPY were significantly and positively associated during stress and 24 hours after stress; NPY and norepinephrine (NE) were significantly and positively related during and 24 hours after stress. There was a significant, negative relationship between psychologic distress and NPY release during stress. Finally, psychologic symptoms of dissociation reported at baseline predicted significantly less NPY release during stress.Conclusions These data replicate our previous studies demonstrating that acute stress elicits NPY release and that this release is positively associated with cortisol and NE release. These data also replicate our previous finding that greater levels of NPY release are associated with less psychologic distress suggesting that NPY confers anxiolytic activity.
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NPY modulates stress responses in animals, and human studies support the possibility that NPY is protective under stress.
“Neuropeptide Y (NPY), a peptide neurotransmitter, modulates stress responses in animals, and studies in humans support the possibility that NPY may represent a protective factor in the face of stress18, 19.”
From Neurobiology of resilience (2012) · cites this paper as [19]
Higher NPY levels in response to acute stress predict less psychological distress and fewer dissociative symptoms.
“higher levels of NPY in response to acute stress predicted less psychological distress and fewer symptoms of dissociation19.”
From Neurobiology of resilience (2012) · cites this paper as [19]
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- Authors
- Morgan, C. A., Rasmusson, A. M., Wang, S., Hoyt, G., Hauger, R. L., & Hazlett, G.
- Affiliations
- Yale University (US)
- United States Navy (US)
- University of California San Diego (US)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 52
- Issue
- 2
- Pages
- 136-142
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2026279809
- Cited by
- 236
- References
- 31
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 11 · 2023: 6 · 2022: 9 · 2021: 5 · 2020: 7 · 2019: 8 · 2018: 16 · 2017: 12 · 2016: 15 · 2015: 15 · 2014: 13 · 2013: 15 · 2012: 8
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- neuropeptide Y, cortisol, acute stress, subjective distress, norepinephrine, dissociation, survival training, military personnel, salivary hormones, plasma hormones, anxiolytic effects, replication
- MeSH terms
- Adult, Analysis of Variance, Epinephrine, Humans, Hydrocortisone, Male, Military Personnel, Neuropeptide Y, Norepinephrine, Psychiatric Status Rating Scales, Saliva, Stress, Physiological, Stress, Psychological
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