The DOI matches its Crossref record; 46 of the 48 references it cites were found in a registry or an index.
Brain activation during script-driven imagery induced dissociative responses in PTSD: a functional magnetic resonance imaging investigation
Abstract
Background The goal of this study was to examine the neuronal circuitry underlying dissociative responses to traumatic script-driven imagery in sexual-abuse-related posttraumatic stress disorder (PTSD). Pilot studies in our laboratory have shown that PTSD patients had very different responses to traumatic script-driven imagery. Approximately 70% of patients relived their traumatic experience and showed an increase in heart rate while recalling the traumatic memory. The other 30% of patients had a dissociative response with no concomitant increase in heart rate. This article focuses on the latter group.Methods The neuronal circuitry underlying dissociative responses in PTSD was studied using the traumatic script-driven symptom provocation paradigm adapted to functional magnetic resonance imaging (fMRI) at a 4 Tesla field strength in 7 subjects with sexual-abuse-related PTSD and 10 control subjects.Results Compared with control subjects, PTSD patients in a dissociative state showed more activation in the superior and middle temporal gyri (BA 38), the inferior frontal gyrus (BA 47), the occipital lobe (BA 19), the parietal lobe (BA 7), the medial frontal gyrus (BA 10), the medial cortex (BA 9), and the anterior cingulate gyrus (BA 24 and 32).Conclusions These findings suggest that prefrontal and limbic structures underlie dissociative responses in PTSD. Differences observed clinically, psychophysiologically, and neurobiologically between patients who respond to traumatic script-driven imagery with dissociative versus nondissociative responses may suggest different neuronal mechanisms underlying these two distinct reactions.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The majority of patients (∼70%) reported marked re-experiencing symptoms and showed a substantial increase in heart rate during the script.”
From Dissociation and Alterations in Brain Function and Structure: Implications for Borderline Personality Disorder (2017) · cites this paper as [57]
In the citing paper
“In a smaller patient group (∼30%), however, this heart rate increase was not observed—instead, these patients showed stronger activity in the medial frontal gyrus, anterior and medial cingulate, middle temporal gyri (BA38), precuneus, occipital areas, and inferior frontal gyrus (IFG), compared to a control group of traumatized persons who had not developed PTSD [57].”
From Dissociation and Alterations in Brain Function and Structure: Implications for Borderline Personality Disorder (2017) · cites this paper as [57]
In the citing paper
“The VLPAG receives signals from deep somatic (muscle, joint) or visceral tissues via the dorsal horn of the spinal cord, from the parabrachial nucleus,25,94,95 and from the vagal sensory nucleus (the solitary track nucleus).28,96”
From Fear and the Defense Cascade (2015) · cites this paper as [95]
In the citing paper
“These findings are consistent with previous reports of an absence of heart-rate increase in response to traumatic scripts among patients with PTSD and comorbid dissociative symptoms (Lanius et al., 2002), and of depressed skin conductance and heart rate when recalling a trauma among rape victims high in peri-traumatic dissociation (Griffin et al., 1997).”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Lanius et al., 2002
In the citing paper
“Further research by Lanius and colleagues (Lanius et al., 2002; Lanius et al., 2005; Lanius et al., 2006) employing trauma memory recall supports the idea of two different PTSD profiles”
From Trauma-related dissociation and the autonomic nervous system: a systematic literature review of psychophysiological correlates of dissociative experiencing in PTSD patients (2022) · cites this paper as Lanius et al., 2002
In the citing paper
“The initial pilot studies describing alternating physiological reactions to individualized trauma scripts in chronic PTSD patients (Lanius et al., 2001; Lanius et al., 2002) interpreted the data as supportive for two distinct subtypes ‘each representing unique pathways to chronic stress- related psychopathology’ (Lanius et al., 2006, p. 710).”
From Trauma-related dissociation and the autonomic nervous system: a systematic literature review of psychophysiological correlates of dissociative experiencing in PTSD patients (2022) · cites this paper as Lanius et al., 2002
Citations
Cites
(1994) · DigitalGeorgetown (Georgetown University Library) · Cited by 10,542
Posttraumatic Stress Disorder in the National Comorbidity Survey
Kessler, R. C. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240066012 · Cited by 10,379
J Neuropsychiatry Clin Neurosci
Yudofsky, S. C., & Hales, R. E. (1992) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.4.4.359 · Cited by 3,818
Development, reliability, and validity of a dissociation scale
BERNSTEIN, E. M., & PUTNAM, F. W. (1986) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198612000-00004 · Cited by 3,793 · cited 2×
“Usually DES scores of 30 or greater indicate a dissociative disorder (Bernstein and Putnam 1986).”
BackgroundMethodDescartes’ Error. Emotion, Reason and the Human Brain. New York (Grosset/Putnam) 1994.
Damasio, A. R. (1994) · Cited by 2,266
Penfield, W. G. (1950) · Digital Commons - RU (Rockefeller University) · Cited by 1,387
A functional anatomical study of unipolar depression
Drevets, W., Videen, T., Price, J., Preskorn, S., Carmichael, S., & Raichle, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-09-03628.1992 · Cited by 1,266
The Cerebral Cortex of Man: A Clinical Study of Localization of Function
(1968) · JAMA · doi:10.1001/jama.1968.03150020096041 · Cited by 1,218
Developmental traumatology part II: brain development∗∗See accompanying Editorial, in this issue.
De Bellis, M. D., Keshavan, M. S., Clark, D. B., Casey, B. J., Giedd, J. N., Boring, A. M., Frustaci, K., & Ryan, N. D. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00045-1 · Cited by 974
Bremner, J. D., Krystal, J. H., Putnam, F. W., Southwick, S. M., Marmar, C., Charney, D. S., & Mazure, C. M. (1998) · Journal of Traumatic Stress · doi:10.1023/a:1024465317902 · Cited by 817
Cited by
Sorted by citations
Items 201–300 of 506
Piefke, M., Pestinger, M., Arin, T., Kohl, B., Kastrau, F., Schnitker, R., Vohn, R., Weber, J., Ohnhaus, M., Erli, H. J., et al. (2008) · Neurocase · doi:10.1080/13554790701851494 · Cited by 47
Aberrant Neural Connectivity During Emotional Processing Associated With Posttraumatic Stress
Sadeh, N., Spielberg, J. M., Warren, S. L., Miller, G. A., & Heller, W. (2014) · Clinical Psychological Science · doi:10.1177/2167702614530113 · Cited by 46
“Findings converge with evidence that individuals with prominent dissociative symptoms show greater insula activation to emotional stimuli (Aupperle, Melrose, Stein, & Paulus, 2012), greater connectivity between regions associated with the representation of bodily states (insula, thalamus) during trauma recall, and red…”
BackgroundCortico-amygdala circuits: Role in the conditioned stress response
Berretta, S. (2005) · Stress · doi:10.1080/10253890500489395 · Cited by 49
“…prefrontal cortex as well as occipital and parietal regions that support visual and spatial aspects of stimuli representations (Bremner 2002; Lanius et al. 2002; Lanius et al. 2003; Liberzon and Phan 2003; Pissiota et al. 2002; Rauch et al. 1996; Shin et al. 1997; Shin et al. 2004).”
BackgroundTrauma-related dissociation: An analysis of two conflicting models
van der Hart, O. (2021) · European Journal of Trauma & Dissociation · doi:10.1016/j.ejtd.2021.100210 · Cited by 49
Hasler, B. P., Insana, S., James, J. A., & Germain, A. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2013.06.007 · Cited by 45
“Other recent reports have specifically linked the precuneus to dissociative responses (Lanius et al., 2002) and dysregulated memory processes in PTSD (Geuze, Vermetten, de Kloet, & Westenberg, 2008; Hayes et al., 2011).”
BackgroundAcute dissociation and cardiac reactivity to script-driven imagery in trauma-related disorders
Sack, M., Cillien, M., & Hopper, J. W. (2012) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v3i0.17419 · Cited by 46
“, 2002) and individualized trauma scripts (Kaufman et al., 2002; Lanius et al., 2002).”
BackgroundResultInfluentialBiological and clinical framework for posttraumatic stress disorder
Vermetten, E. H. G. J. M., & Lanius, R. A. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52002-9.00018-8 · Cited by 50
Self-citationSingleton, S. P., Wang, J. B., Mithoefer, M. C., Hanlon, C. A., George, M. S., Mithoefer, A., Mithoefer, O. J., Coker, A. R., Yazar‐Klosinski, B., Emerson, A., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.947622 · Cited by 46
Yehuda, R., Harvey, P. D., Golier, J. A., Newmark, R. E., Bowie, C. R., Wohltmann, J. J., Grossman, R. A., Schmeidler, J., Hazlett, E. A., & Buchsbaum, M. S. (2009) · Journal of Neuropsychiatry · doi:10.1176/jnp.2009.21.2.132 · Cited by 45
Neural Network Modulation by Trauma as a Marker of Resilience
James, L. M., Engdahl, B. E., Leuthold, A., Lewis, S. M., Kampen, E. V., & Georgopoulos, A. P. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.878 · Cited by 44
Kosslyn, S. M. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050406 · Cited by 43
Deppermann, S., Notzon, S., Kroczek, A., Rosenbaum, D., Haeussinger, F. B., Diemer, J., Domschke, K., Fallgatter, A. J., Ehlis, A., & Zwanzger, P. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.03.028 · Cited by 40
Precuneal activity during encoding in veterans with posttraumatic stress disorder
Geuze, E., Vermetten, E. H. G. J. M., de Kloet, C. S., & Westenberg, H. G. M. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)67026-5 · Cited by 42
Vermetten, E. H. G. J. M., & Bremner, J. D. (2004) · International Journal of Clinical and Experimental Hypnosis · doi:10.1080/0020714049052352 · Cited by 41
“Within a general framework of identification, production, and regulation of emotional recall (see Phillips et al., 2003), hypnotic response patterns are related to the involvement of different brain correlates (Lanius et al., 2002).”
BackgroundMethodInfluentialDistinguishing Neural Substrates of Heterogeneity Among Anxiety Disorders
Nitschke, J. B., & Heller, W. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)67001-8 · Cited by 40
Daniels, J. K., Frewen, P., Theberge, J., & Lanius, R. A. (2016) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12464 · Cited by 40
Self-citationNeuroimaging in Anxiety Disorders
Fredrikson, M. G., & Faria, V. (2013) · Modern trends in psychiatry · doi:10.1159/000351938 · Cited by 42
Kent, L., Nelson, B., & Northoff, G. (2022) · Early Intervention in Psychiatry · doi:10.1111/eip.13333 · Cited by 39
“Dissociation is a common feature of PTSD (Lanius et al., 2002), which also plays a mediating role between childhood trauma and later dissociation (Terock et al., 2016).”
BackgroundNeurobiological response to EMDR therapy in clients with different psychological traumas
Pagani, M., Lorenzo, G. D., Monaco, L., Daverio, A., Giannoudas, I., Porta, P. L., Verardo, A. R., Niolu, C., Fernández, I., & Siracusano, A. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01614 · Cited by 43
“…have described significant neurobiological alterations in patients with PTSD while both reliving psychological traumas (Shin et al., 1999, 2004; Lanius et al., 2002, 2003; Lindauer et al., 2004; Britton et al., 2005; Osuch et al., 2008) and during resting state (Todder et al., 2012; Lee et…”
BackgroundFace processing in depersonalization: An fMRI study of the unfamiliar self
Ketay, S., Hamilton, H., Haas, B. W., & Simeon, D. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.02.003 · Cited by 37
Putica, A., Dam, N. V. V., Steward, T., Agathos, J. A., Felmingham, K., & O'Donnell, M. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.09.100 · Cited by 33
Li, L., Zhang, Y., Zhao, Y., Li, Z., Kemp, G. J., Wu, M., & Gong, Q. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.104519 · Cited by 40
“, 2003); and that higher activation of the right superior temporal gyrus is related to the severity of PTSD, especially for patients with dissociation symptoms (Cwik et al., 2017; Hopper, 2007; Lanius et al., 2002); and a positive correlation between the intensity of dissociation symptoms and”
BackgroundKlanecky, A. K., McChargue, D. E., & Bruggeman, L. (2012) · American Journal on Addictions · doi:10.1111/j.1521-0391.2012.00228.x · Cited by 36
Egocentric spatial learning in schizophrenia investigated with functional magnetic resonance imaging
Siemerkus, J., Irle, E., Schmidt‐Samoa, C., Dechent, P., & Weniger, G. (2012) · NeuroImage Clinical · doi:10.1016/j.nicl.2012.10.004 · Cited by 36
“Previous research has already indicated that trauma-related dissociative states are related to increased activity of the precuneus (Lanius et al., 2002).”
The Impact of Maltreatment on the Developing Child
Hagele, D. (2005) · North Carolina Medical Journal · doi:10.18043/ncm.66.5.356 · Cited by 35
Degrading traumatic memories with eye movements: a pilot functional MRI study in PTSD
Thomaes, K., Engelhard, I. M., Sijbrandij, M., Cath, D. C., & van den Heuvel, O. A. (2016) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v7.31371 · Cited by 38
“…has shown to produce highly reliable psychophysiological and neuro-biological responses (e.g., Orr & Roth, 2000; Pitman, Orr, Forgue, De Jong, & Claiborn, 1987), has recently been used in a study of the effects of EMs (Kearns & Engelhard, 2015), and has been adapted for fMRI (Lanius et al., 2002).”
Askovic, M., Watters, A. J., Coello, M., Aroche, J., Harris, A. W. F., & Kropotov, J. D. (2019) · Clinical EEG and Neuroscience · doi:10.1177/1550059419849170 · Cited by 35
“If replicated, the current findings would be generalizable to other cases of chronic PTSD.”
BackgroundInfluentialPsychological trauma in chronic pain: Implications of PTSD for fibromyalgia and headache disorders
Peres, J. F. P., Gonçalves, A. L., & Peres, M. F. P. (2009) · Current Pain and Headache Reports · doi:10.1007/s11916-009-0057-2 · Cited by 37
“The second pattern (dissociative) showed heightened activity of the mid-prefrontal cortex resulting in inhibition of amygdala activity, blunting the sympathetic response and leading to emotional numbing [ 18 ].”
BackgroundDissociation in the Binge–Purge Cycle of Bulimia Nervosa
McShane, J. M., & Zirkel, S. (2008) · Journal of Trauma & Dissociation · doi:10.1080/15299730802225680 · Cited by 35
Posttraumatic Stress Disorder Part III: Health Effects of Interpersonal Violence Among Women
Hegadoren, K., Lasiuk, G. C., & Coupland, N. J. (2006) · Perspectives In Psychiatric Care · doi:10.1111/j.1744-6163.2006.00078.x · Cited by 35
“Recent evidence from neuroimaging studies suggests that brain activation patterns differ between those with PTSD dominated by arousal symptoms and those with PTSD dominated by dissociative symptoms (Lanius et al., 2002).”
BackgroundAutonomic responses to fear conditioning among women with PTSD and dissociation
Seligowski, A. V., Lebois, L. A. M., Hill, S. B., Kahhale, I., Wolff, J. D., Jovanovic, T., Winternitz, S. R., Kaufman, M. L., & Ressler, K. J. (2019) · Depression and Anxiety · doi:10.1002/da.22903 · Cited by 34
“…RSA as a parasympathetic nervous system measure of vagal regulation, our results also suggest that dissociation was related to a greater tendency to regulate fear and physiological reactivity in our study, which is consistent with prior research (e.g., D’Andrea et al., 2013; Lanius et al., 2002).”
Nicholson, A. A., Rabellino, D., Densmore, M., Frewen, P., Steyrl, D., Scharnowski, F., Théberge, J., Neufeld, R. W. J., Schmahl, C. G., Jetly, R., et al. (2021) · Brain and Behavior · doi:10.1002/brb3.2441 · Cited by 37
“Additionally, the superior, inferior, and mid-temporal gyri have been shown to display increased activation in response to trauma-related stimuli and have been correlated to PTSD symptoms of avoidance and dissociation (Lanius et al., 2002; Hopper et al., 2007b; Nilsen et al., 2016).”
BackgroundSelf-citationNickerson, A., Garber, B., Liddell, B. J., Litz, B. T., Hofmann, S. G., Asnaani, A., Ahmed, O. M. A., Cheung, J., Huynh, L., Pajak, R., et al. (2017) · Clinical Psychological Science · doi:10.1177/2167702617690857 · Cited by 35
“Theorists assert that responses characterized by hypoarousal may thus be expected when individuals high in dissociative symptoms are presented with trauma reminders in laboratory settings (Griffin, Resick, & Mechanic, 1997; Lanius et al., 2002), with empirical evidence supporting this (Griffin et al.”
BackgroundCurrent Understanding of the Neural Mechanisms of Dissociation in Borderline Personality Disorder
Krause-Utz, A., & Elzinga, B. M. (2018) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-018-0146-9 · Cited by 36
“dial frontal gyrus, anterior cingulate, middle temporal gyri, precuneus, occipital areas, and inferior frontal gyrus) [87].”
BackgroundNeurotrophic factors and hippocampal activity in PTSD
Tural, Ü., Aker, A. T., Önder, E., Turan, H. S., Ünver, H., & Akansel, G. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197889 · Cited by 32
del Río-Casanova, L., González, A., Páramo, M., Van Dijke, A., & Brenlla, J. (2016) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0045 · Cited by 32
“A difficulty to activate normal vegetative responses to emotional stimuli was found in patients with PTSD and dissociative symptoms (compared to other PTSD subjects) (Ladwig et al., 2002; Lanius et al., 2002; Hopper et al., 2007; Hetzel-Riggin and Wilber, 2010).”
BackgroundBae, K., Kim, D.-W., Im, C., & Lee, S. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.08.002 · Cited by 31
“A substantial proportion of patients with PTSD reported dissociative symptoms that may be associated with altered self-perception (Lanius et al., 2002, 2005).”
BackgroundPsychotherapy and neuroscience: Towards closer integration
Peres, J., & Nasello, A. G. (2008) · International Journal of Psychology · doi:10.1080/00207590701248487 · Cited by 35
Natural Memory Beyond the Storage Model: Repression, Trauma, and the Construction of a Personal Past
Axmacher, N., Lam, A. T. A. D., Kessler, H., & Fell, J. (2010) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00211 · Cited by 37
Ten reasons for conceiving and classifying posttraumatic stress disorder as a dissociative disorder
Nijenhuis, E. R. S. (2017) · European Journal of Trauma & Dissociation · doi:10.1016/j.ejtd.2017.01.001 · Cited by 37
van Oort, J., Kohn, N., Vrijsen, J. N., Collard, R. M., Duyser, F. A., Brolsma, S. C. A., Fernández, G., Schene, A. H., Tendolkar, I., & van Eijndhoven, P. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102176 · Cited by 36
Junior, D. A. D. A., Sair, H. I., Peters, M. E., Carvalho, A. F., Yedavalli, V. S., Sólnes, L. B., & Luna, L. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.06.016 · Cited by 34
Assessing the structure and meaningfulness of the dissociative subtype of PTSD
Ross, J., Baník, G., Dědová, M., Mikulášková, G., & Armour, C. (2017) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-017-1445-2 · Cited by 38
“[14, 15] has provided support for the mechanism requirement of the Subtype model of dissociative PTSD.”
BackgroundSimões, M. A., Monteiro, R., Andrade, J., Mouga, S., França, F. M. G., Oliveira, G., Carvalho, P., & Castelo-Branco, M. S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00791 · Cited by 31
Frontal Lobe Circuitry in Posttraumatic Stress Disorder
Selemon, L. D., Young, K. A., Cruz, D. A., & Williamson, D. E. (2019) · Chronic Stress · doi:10.1177/2470547019850166 · Cited by 34
Koopman, C., Sephton, S. E., Abercrombie, H. C., Classen, C. C., Butler, L. D., Gore-Felton, C. E., Borggrefe, A., & Spiegel, D. (2003) · Journal of Trauma & Dissociation · doi:10.1300/j229v04n04_03 · Cited by 31
“This is supported by evidence that women with PTSD for sexual abuse who were high dissociators showed no increase in heart rate in response to recalling a traumatic memory, in contrast to women with PTSD for sexual abuse who were low dissociators (Lanius et al., 2002).”
MethodKim, S. N., Kang, D., Yun, J., Lee, T. Y., Jung, W. H., Jang, J. H., & Kwon, J. S. (2013) · Psychiatry Investigation · doi:10.4306/pi.2013.10.2.173 · Cited by 29
Brain activation and heart rate during script-driven traumatic imagery in PTSD: Preliminary findings
Barkay, G., Freedman, N., Lester, H., Louzoun, Y., Sapoznikov, D., Luckenbaugh, D. A., Shalev, A. Y., Chisin, R., & Bonne, O. B. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.08.007 · Cited by 30
“An fMRI study revealed relatively larger activation of the occipital lobe in PTSD subjects who developed a dissociative response during traumatic script exposure compared with non-PTSD controls (Lanius et al., 2002).”
ResultAmad, A., Raduà, J., Vaïva, G., Williams, S., & Fovet, T. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.07.018 · Cited by 30
Current and future functional imaging techniques for post-traumatic stress disorder
Prasad, A., Chaichi, A., Kelley, D. P., Francis, J., & Gartia, M. R. (2019) · RSC Advances · doi:10.1039/c9ra03562a · Cited by 32
Directed threat imagery in generalized anxiety disorder
Buff, C., Schmidt, C. C., Brinkmann, L., Gathmann, B., Tupak, S. V., & Straube, T. (2017) · Psychological Medicine · doi:10.1017/s0033291717001957 · Cited by 32
“and results in potentiation of startle responses, increased autonomic arousal (heart rate, skin conductance) and the recruitment of a fear-related brain circuitry including elevated activity in the amygdala, insula, cingulate cortex, prefrontal cortex (PFC) and the hippocampus, as well as reduced activity in the thala…”
BackgroundRowland, G. E., Mekawi, Y., Michopoulos, V., Powers, A. D., Fani, N., Bradley, B., Ressler, K. J., Jovanović, T., & Stevens, J. S. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.08.099 · Cited by 34
Hallock, H. L., Quillian, H. M., Maynard, K. R., Mai, Y., Chen, H.-Y., Hamersky, G. R., Shin, J. H., Maher, B. J., Jaffe, A. E., & Martinowich, K. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.04.014 · Cited by 25
Schäflein, E., Sattel, H., Schmidt, U., & Sack, M. (2018) · European Journal of Psychotraumatology · doi:10.1080/20008198.2018.1472991 · Cited by 28
“…psychophysiological hyperarousal under stressful conditions, exhibit blunted autonomic reactivity and are thus classified as ‘physiological nonresponders’ (Orr, Metzger, & Pitman, 2002; Orr & Roth, 2000) or ‘dissociative subtype’ of PTSD (Lanius, Bluhm, Lanius, & Pain, 2006; Lanius et al., 2002).”
BackgroundReduction of anterior cingulate in adults with urban violence- related PTSD
Baldaçara, L., Zugman, A., de Araújo, C. M., Cogo‐Moreira, H., Lacerda, A. L. T., Schoedl, A. F., Pupo, M. C., Mello, M. F., Andreoli, S. B., Mari, J. D. J., et al. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.06.036 · Cited by 27
“The rACC, however, was hyperactive in dissociative states (Lanius et al., 2002).”
BackgroundFeng, T., Feng, P., & Chen, Z. (2013) · Brain Research · doi:10.1016/j.brainres.2013.05.039 · Cited by 27
Bichescu‐Burian, D., Steyer, J., Steinert, T., Grieb, B., & Tschöke, S. (2017) · Psychophysiology · doi:10.1111/psyp.12795 · Cited by 27
Bremner, J. D. (2007) · Cambridge University Press eBooks · doi:10.1017/cbo9780511500008.010 · Cited by 28
Functional neuroimaging in mental disorders.
McGuire, P. K., & Matsumoto, K. (2004) · Europe PMC (PubMed Central) · Cited by 27
Does Dissociation Offer a Useful Explanation for Psychopathology?
Jureidini, J. N. (2004) · Psychopathology · doi:10.1159/000081981 · Cited by 27
Moser, D. A., Aue, T., Wang, Z., Rusconi Serpa, S., Favez, N., Peterson, B. S., & Schechter, D. S. (2013) · Stress · doi:10.3109/10253890.2013.816280 · Cited by 26
“Dissociation is commonly described as one form of a psychological reaction to stress which, when generalized beyond the acute peritraumatic period, can itself become an impairing form of psychopathology that is distinct from, yet related to PTSD. PTSD and dissociation share an overlap in the avoidance symptom cluster…”
BackgroundInfluentialTargeted memory reactivation to augment treatment in post-traumatic stress disorder
van der Heijden, A. C., van der Werf, Y. D., van den Heuvel, O. A., Talamini, L. M., & van Marle, H. J. F. (2024) · Current Biology · doi:10.1016/j.cub.2024.07.019 · Cited by 30
Zhu, H., Qiu, C., Meng, Y., Cui, H., Zhang, Y., Huang, X., Zhang, J., Li, T., Gong, Q., Zhang, W., et al. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.11.053 · Cited by 26
“The hyperactive spontaneous activity of visual cortex was consistent with previous findings in PTSD using task-based fMRI (Morris et al., 2001; Lanius et al., 2002; Bremner et al., 2003b).”
ResultBeing in Rhythm: Dissociative Attunement in Therapeutic Process
Hopenwasser, K. (2008) · Journal of Trauma & Dissociation · doi:10.1080/15299730802139212 · Cited by 26
“Books about stress and posttraumatic stress disorders included chapters addressing the neurochemistry of dissociation (Krystal, Bennett, Bremner, Southwick, & Charney, 1995; Scaer, 2001) while brain imaging studies were addressing the neurobiology of posttraumatic dissociative states (Bremner et al., 1997, 1999; Frewe…”
BackgroundKlimova, A., Bryant, R. A., Williams, L. M., & Felmingham, K. L. (2013) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v4i0.20430 · Cited by 27
“…activation in prefrontal regulatory networks (specifically medial prefrontal gyrus and anterior cingulate cortex) compared to the typically reduced activity in these prefrontal networks seen in PTSD patients with predominant hyperarousal responses (Felmingham et al., 2008; Lanius et al., 2002).”
BackgroundMethodTrauma or Drama: A Predictive Processing Perspective on the Continuum of Stress
Krupnik, V. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.01248 · Cited by 39
Nees, F., Witt, S. H., & Flor, H. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.12.015 · Cited by 28
Cingulate subregions in posttraumatic stress disorder, chronic stress, and treatment
Hinojosa, C. A., Kaur, N., VanElzakker, M. B., & Shin, L. M. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64196-0.00020-0 · Cited by 26
A meta‐analysis of the association between shame and dissociation
Rudy, J. A., McKernan, S. M., Kouri, N. A., & D'Andrea, W. M. (2022) · Journal of Traumatic Stress · doi:10.1002/jts.22854 · Cited by 28
Daniels, J. K., Hegadoren, K., Coupland, N. J., Rowe, B. H., Neufeld, R. W. J., & Lanius, R. A. (2011) · Psychological Medicine · doi:10.1017/s0033291711000237 · Cited by 28
“Convergently, the implication of the globus pallidus in the recall of traumatic memories has been reported previously by our group (Lanius et al. 2002 ; Lanius et al. 2004).”
BackgroundSelf-citationJung, W. H., Chang, K. J., & Kim, N. H. (2016) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2016.03.003 · Cited by 26
“For example, several previous studies reported altered parahippocampal activity in PTSD (Etkin and Wager, 2007; Lanius et al., 2002; Sakamoto et al., 2005) and atypical restingstate hippocampal connectivity associated with symptom severity in PTSD (Dunkley et al.”
BackgroundThe Dissociative Subtype of PTSD Interview (DSP-I): Development and Psychometric Properties
Eidhof, M. B., ter Heide, F. J. J., van der Aa, N., Schreckenbach, M., Schmidt, U., Brand, B. L., Lanius, R. A., Loewenstein, R. J., Spiegel, D., & Vermetten, E. H. G. J. M. (2019) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2019.1597806 · Cited by 25
“Prior to the introduction of the PTSD-DS in the DSM-5, research has relied on measures that were not validated for assessment of the PTSD-DS construct (Blevins et al., 2014; Lanius et al., 2002; Stein et al., 2013; Steuwe et al., 2012; Wolf et al., 2012).”
MethodSelf-citationImpact of stress resilience and susceptibility on fear learning, anxiety, and alcohol intake
Gonzalez, S. T., Marty, V. N., Spigelman, I., Reise, S. P., & Fanselow, M. S. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100335 · Cited by 27
Thierrée, S., Raulin-Briot, M., Legrand, M., Gouge, A. L., Vancappel, A., Tudorache, A., Brizard, B., Clarys, D., Caille, A., & El‐Hage, W. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13505 · Cited by 23
Dutra, S. J., & Wolf, E. J. (2016) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2016.10.003 · Cited by 27
Bowen, A., Shelley, M., Helmes, E., & Landman, M. (2009) · Anxiety Stress & Coping · doi:10.1080/10615800903414315 · Cited by 24
“The PTSD symptom of dissociation has been linked to disclosure in therapeutic relationships (e.g., Koopman et al., 2001; Lanius et al., 2002).”
Balters, S., Li, R., Espil, F. M., Piccirilli, A. M., Liu, N., Gundran, A., Carrión, V. G., Weems, C. F., Cohen, J. A., & Reiss, A. L. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.10.020 · Cited by 24
Sleep as a window to target traumatic memories
van der Heijden, A. C., van den Heuvel, O. A., van der Werf, Y. D., Talamini, L. M., & van Marle, H. J. F. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104765 · Cited by 26
Schechter, D. S., Moser, D. A., McCaw, J. E., & Myers, M. M. (2013) · Developmental Psychobiology · doi:10.1002/dev.21144 · Cited by 24
“, 1999); but three studies that included both physical and sexual violence exposure did not (Halligan et al., 2006; Lanius et al., 2002; Schmahl et al., 2004).”
BackgroundKrüger, C., Bartel, P., & Fletcher, L. (2013) · Journal of Trauma & Dissociation · doi:10.1080/15299732.2013.769480 · Cited by 23
“In addition, the nature of this study did not allow for an evaluation of the cortico-limbic inhibition model of dissociation (Lanius, Bluhm, Lanius, & Pain, 2006; Lanius et al., 2002).”
BackgroundMoral reasoning in women with posttraumatic stress disorder related to childhood abuse
Nazarov, A., Walaszczyk, V., Frewen, P., Oremus, C., Lanius, R. A., & McKinnon, M. C. (2016) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v7.31028 · Cited by 24
“…individuals who exhibit symptoms of hyperarousal or re-experiencing reactivity compared to those who experience dissociative symptomatology (Bremner, 1999; Lanius, Bluhm, Lanius, & Pain, 2006; Lanius, Brand, Vermetten, Frewen, & Spiegel, 2012; Lanius et al., 2002; Lanius, Vermetten, et al., 2010).”
BackgroundSelf-citationMertens, Y. L., Manthey, A., Sierk, A., Walter, H., & Daniels, J. K. (2022) · BJPsych Open · doi:10.1192/bjo.2022.65 · Cited by 23
Nathan, D. E., Bellgowan, J. F., French, L. M., Wolf, J., Oakes, T. R., Mielke, J. B., Sham, E. B., Liu, W., & Riedy, G. P. (2017) · Brain Connectivity · doi:10.1089/brain.2016.0433 · Cited by 22
“…in episodic and autobiographical memory encoding and storage, and that this region may be a part of the temporal lobe network, therefore being abnormally active in PTSD (Eichenbaum et al., 2007; Lanius et al., 2002; Sakamoto et al., 2005; Squire and Zola-Morgan, 1991; Thomaes et al., 2009).”
InfluentialSierk, A., Manthey, A., King, J. A., Brewin, C. R., Bisby, J. A., Walter, H., Burgess, N., & Daniels, J. K. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.107093 · Cited by 25
“According to the published procedure (Lanius et al., 2002), individualised scripts containing descriptions of one neutral and one traumatic event in the patient’s life were created.”
EMDR therapy for PTSD after motor vehicle accidents: meta-analytic evidence for specific treatment
Boccia, M., Piccardi, L., Cordellieri, P., Guariglia, C., & Giannini, A. M. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00213 · Cited by 25
“Actually, EMDR has been successfully used, to treat PTSD after different traumatic events (Lansing et al., 2005; El KhouryMalhame et al., 2011; Bisson et al., 2013).”
BackgroundMethodResultInfluentialDissociation as a trauma-related phenomenon.
Brand, B. L., & Frewen, P. (2017) · American Psychological Association eBooks · doi:10.1037/0000019-013 · Cited by 23
Weniger, G., Siemerkus, J., Barke, A., Lange, C., Ruhleder, M., Sachsse, U., Schmidt‐Samoa, C., Dechent, P., & Irle, E. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.11.004 · Cited by 22
Trauma-related disorders and the bodily self: current perspectives and future directions
Laricchiuta, D., Garofalo, C., & Mazzeschi, C. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1166127 · Cited by 26
“Accordingly, neuroimaging studies of subjects with PTSD + DS have suggested altered activity in brain regions involved in multisensory integration (Simeon et al., 2000; Lanius et al., 2002; Felmingham et al., 2008), such as modified vestibular nuclei functional connectivity with key cortical vestibular regions (Harric…”
BackgroundLieberman, J. M., Rabellino, D., Densmore, M., Frewen, P., Steyrl, D., Scharnowski, F., Théberge, J., Hosseini‐Kamkar, N., Neufeld, R. W. J., Jetly, R., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1229729 · Cited by 20
Self-citationGoethals, I., Jacobs, F., van der Linden, C., Caemaert, J., & Audenaert, K. (2008) · Journal of Trauma & Dissociation · doi:10.1080/15299730802226126 · Cited by 20
“Also, in patients with posttraumatic stress disorder, prefrontal, temporal, parietal, and occipital lobes appeared to be involved in exhibiting dissociative responses ( Lanius et al, 2002 ).”
BackgroundBiological framework for traumatic dissociation related to early life trauma
Christian, S., Lanius, R. A., Pain, C. C., & Vermetten, E. H. G. J. M. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511777042.021 · Cited by 20
Self-citationCardiac reactions to emotional words in adolescents and young adults with PTSD after child abuse
Iffland, B., Klein, F., Rosner, R., Renneberg, B., Steil, R., & Neuner, F. (2019) · Psychophysiology · doi:10.1111/psyp.13470 · Cited by 20
“Contrasted with previous reports (Lanius et al., 2002; Sack et al., 2012), however, dissociative symptoms were not associated with cardiac reactivity in the present study.”
BackgroundResultInfluentialSierk, A., Manthey, A., Brakemeier, E., Walter, H., & Daniels, J. K. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00274-x · Cited by 24
Parlar, M. E., Densmore, M., Hall, G. B., Frewen, P., Lanius, R. A., & McKinnon, M. C. (2017) · Brain and Behavior · doi:10.1002/brb3.664 · Cited by 21
“The right MTG has been implicated in dissociative states, where patients with PTSD who dissociated during an fMRI traumatic script- driven imagery paradigm demonstrated heightened levels of activation in this region, compared to controls (Lanius et al., 2002).”
BackgroundSelf-citationSeghete, K. L. M., Kaiser, R. H., DePrince, A. P., & Banich, M. T. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.06.030 · Cited by 21
Cardiac defense in response to imminent threat in women with multiple trauma and severe PTSD
Schalinski, I., Elbert, T. R., & Schauer, M. (2013) · Psychophysiology · doi:10.1111/psyp.12051 · Cited by 20
Lee, M., Anumagalla, P., & Pavuluri, M. N. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00303-9 · Cited by 20
“Brain Activation during Script-Driven Imagery Induced Dissociative Responses in PTSD (Lanius et al. 2002) 7 female subjects with sexual-abuse-related PTSD (mean age: 36 ± 10.”
MethodInfluentialBabson, K. A., Badour, C. L., Feldner, M. T., & Bunaciu, L. (2012) · Journal of Traumatic Stress · doi:10.1002/jts.21739 · Cited by 19
Dissociation and pain perception: An experimental investigation
Horowitz, J. D., & Telch, M. J. (2007) · Journal of Traumatic Stress · doi:10.1002/jts.20226 · Cited by 19
“Lanius et al. (2002) asked trauma victims to relive their traumatic experiences while undergoing functional magnetic resonance imaging (fMRI) and found that only those participants who did not dissociate during the procedure displayed an increase in heart rate.”
BackgroundFunctional Neuroimaging in Post-Traumatic Stress Disorder
Liberzon, I., & Garfinkel, S. N. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-329-9_14 · Cited by 19
Metadata
- Authors
- Lanius, R. A., Williamson, P. C., Boksman, K., Densmore, M., Gupta, M., Neufeld, R. W. J., Gati, J. S., & Menon, R. S.
- Affiliations
- Western University (CA)
- Robarts Research Institute (CA)
- Corresponding author
- Lanius, Ruth A
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 52
- Issue
- 4
- Pages
- 305-311
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1966297906
- Cited by
- 505
- References
- 48
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 10 · 2023: 17 · 2022: 23 · 2021: 18 · 2020: 24 · 2019: 24 · 2018: 12 · 2017: 25 · 2016: 17 · 2015: 23 · 2014: 27 · 2013: 28 · 2012: 25
- FWCI
- 23.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- post-traumatic stress disorder, dissociation, script-driven imagery, sexual abuse, brain activation, prefrontal cortex, limbic system, anterior cingulate cortex, temporal lobe, heart rate response
- MeSH terms
- Adult, Arousal, Brain, Brain Mapping, Child, Child Abuse, Child Abuse, Sexual, Dissociative Disorders, Female, Gyrus Cinguli, Humans, Imagination, Magnetic Resonance Imaging, Nerve Net, Mental Recall, Stress Disorders, Post-Traumatic, Temporal Lobe, Prefrontal Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
