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Cited by 119Posttraumatic Stress Disorder ResearchTraumatic Brain Injury ResearchPsychoanalysis and Psychopathology Research

Cerebral blood flow changes during script-driven imagery in police officers with posttraumatic stress disorder

Lindauer, Ramón J.L., Booij, Jan, Habraken, Jan B.A., Uylings, Harry B.M., Olff, Miranda, Carlier, Ingrid V.E., den Heeten, Gerard J., van Eck-Smit, Berthe L.F. +1 more·2004·Biological Psychiatry
DOI 10.1016/j.biopsych.2004.08.003
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Abstract

Background Functional brain imaging studies in posttraumatic stress disorder (PTSD) have focused mostly on war or sexual abuse victims, many of whom also had comorbid disorders. The aim of this study was to examine the neuronal circuitry underlying responses to script-driven imagery in traumatized police officers with and without PTSD and with low comorbidity rates. Methods In a case-matched control study, 30 traumatized police officers with and without PTSD underwent clinical assessment and (99m)technetium-hexa-methyl-propylene-amine-oxime single photon emission computed tomography scanning with neutral and trauma scripts. Statistical parametric mapping was applied to analyze changes in regional cerebral blood flow. Results The main findings were significantly less activation in the medial frontal gyrus and more activation in the right cuneus in the PTSD group relative to the trauma-exposed control group in reaction to trauma versus neutral scripts. Within the PTSD group, subjects showed less activation in the superior temporal gyrus, left lentiform nucleus, left middle frontal gyrus, and left inferior frontal gyrus in reaction to trauma scripts. Conclusions We confirmed previous findings of dysfunction of the medial frontal gyrus in PTSD in a new population with low comorbidity rates. Other alterations were found in certain brain structures involved in emotional, memory, linguistic, visuospatial, and motor processing.

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  • Lindauer et al. (2004) observed lower activation in the medial frontal gyrus in response to traumatic versus neutral scripts among police officers with PTSD exposed to trauma compared to those without PTSD.

    “Furthermore, by applying SPECT in their work, Lindauer et al. (2004) observed lower activation in the medial frontal gyrus in response to traumatic versus neutral scripts among police officers with PTSD exposed to trauma, compared to those without PTSD.”

    From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Lindauer et al. (2004)

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Authors
Lindauer, R. J. L., Booij, J., Habraken, J. B. A., Uylings, H. B. M., Olff, M., Carlier, I. V. E., den Heeten, G. J., van Eck-Smit, B. L. F., & Gersons, B. P. R.
Affiliations
  • Amsterdam UMC Location University of Amsterdam (NL)
  • Royal Netherlands Academy of Arts and Sciences (NL)
  • Altrecht GGZ (NL)
Corresponding author
Lindauer, Ramón J.L.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2004-12
Volume
56
Issue
11
Pages
853-861
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2004.08.003
OpenAlex
W2127909094
Cited by
119
References
69
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 8 · 2019: 6 · 2018: 2 · 2017: 8 · 2016: 9 · 2015: 6 · 2014: 11 · 2013: 6 · 2012: 8
FWCI
6.08
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords
post-traumatic stress disorder, script-driven imagery, police officers, cerebral blood flow, medial frontal gyrus, cuneus, trauma exposure, PTSD comorbidity, emotional processing, memory processes
MeSH terms
Adult, Brain, Brain Mapping, Cerebrovascular Circulation, Demography, Female, Humans, Male, Middle Aged, Regional Blood Flow, Stress Disorders, Post-Traumatic, Verbal Behavior, Tomography, Emission-Computed, Single-Photon, Case-Control Studies, Police, Imagery, Psychotherapy

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