The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Neural abnormalities during cognitive generation of affect in Treatment-Resistant depression
Abstract
Background Dysfunctions in brain regions known to be involved in affect and mood states are thought to be implicated in depression and may have a role in determining the type and symptoms of this illness.Methods Functional magnetic resonance imaging was used to elucidate neural correlates of cognitive generation of affect, using a previously published paradigm of evoking affect with picture-caption pairs, in patients with unipolar, treatment-resistant depression.Results Compared with control participants, patients showed relatively decreased response in the anterior cingulate (rostral; right) with both negative and positive picture-caption pairs and in the medial frontal gyrus and hippocampus (all left) with positive picture-caption pairs. They demonstrated increased response in the inferior (right) and middle temporal gyri (left) with negative picture-caption pairs, and in the parahippocampal gyrus (right), inferior frontal gyrus (left), subgenual cingulate (right), striatum (right), and brain stem (left) with positive picture-caption pairs.Conclusions Reduced medial/middle prefrontal and hippocampal activity may account for positive affect disturbances and temporal lobe hyperactivity for negative affect disturbances in treatment-resistant depression. The results also corroborate previous observations from resting positron emission tomography studies and further elucidate the association between hypoactive rostral cingulate and nonresponsiveness to treatment in depression.
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“Functional neuroimaging studies in MDD have consistently indicated hypoactivation in reward-processing regions, including the dorsal and ventral striatum [210-214] and a host of other reward structures, including the medial prefrontal cortex [215,216], the pregenual and subgenual anterior cingulate, and the medial frontal gyrus [217,218].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [215]
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The integration of negative affect, pain and cognitive control in the cingulate cortex
Shackman, A. J., Salomons, T. V., Slagter, H. A., Fox, A. S., Winter, J. J., & Davidson, R. J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2994 · Cited by 2,082
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Anand, A., Li, Y., Wang, Y., Wu, J., Gao, S., Bukhari, L., Mathews, V. P., Kalnin, A., & Lowe, M. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.021 · Cited by 787
Metadata
- Authors
- Kumari, V., Mitterschiffthaler, M. T., Teasdale, J. D., Malhi, G. S., Brown, R. G., Giampietro, V., Brammer, M. J., Poon, L., Simmons, A., Williams, S. C. R., Checkley, S. A., & Sharma, T.
- Affiliations
- King's College London (GB)
- MRC Cognition and Brain Sciences Unit (GB)
- UNSW Sydney (AU)
- Corresponding author
- Sharma, Tonmoy
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 54
- Issue
- 8
- Pages
- 777-791
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2048350205
- Cited by
- 166
- References
- 71
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 10 · 2018: 7 · 2017: 4 · 2016: 3 · 2015: 12 · 2014: 3 · 2013: 5 · 2012: 10
- FWCI
- 7.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- treatment-resistant depression, rostral anterior cingulate cortex, medial prefrontal cortex, hippocampus, subgenual cingulate, striatum, parahippocampal gyrus, inferior frontal gyrus, brainstem
- MeSH terms
- Adult, Affect, Antidepressive Agents, Brain, Cognition Disorders, Depressive Disorder, Major, Major Depressive Disorder, Drug Resistance, Female, Humans, Magnetic Resonance Imaging, Middle Aged
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