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Cited by 166Treatment of Major DepressionNeural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.

Neural abnormalities during cognitive generation of affect in Treatment-Resistant depression

Kumari, Veena, Mitterschiffthaler, Martina T, Teasdale, John D, Malhi, Gin S, Brown, Richard G, Giampietro, Vincent, Brammer, Michael J, Poon, Lucia, Simmons, Andrew, Williams, Steven C.R, Checkley, Stuart A, Sharma, Tonmoy·2003·Biological Psychiatry
DOI 10.1016/s0006-3223(02)01785-7
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Abstract

Background Dysfunctions in brain regions known to be involved in affect and mood states are thought to be implicated in depression and may have a role in determining the type and symptoms of this illness.Methods Functional magnetic resonance imaging was used to elucidate neural correlates of cognitive generation of affect, using a previously published paradigm of evoking affect with picture-caption pairs, in patients with unipolar, treatment-resistant depression.Results Compared with control participants, patients showed relatively decreased response in the anterior cingulate (rostral; right) with both negative and positive picture-caption pairs and in the medial frontal gyrus and hippocampus (all left) with positive picture-caption pairs. They demonstrated increased response in the inferior (right) and middle temporal gyri (left) with negative picture-caption pairs, and in the parahippocampal gyrus (right), inferior frontal gyrus (left), subgenual cingulate (right), striatum (right), and brain stem (left) with positive picture-caption pairs.Conclusions Reduced medial/middle prefrontal and hippocampal activity may account for positive affect disturbances and temporal lobe hyperactivity for negative affect disturbances in treatment-resistant depression. The results also corroborate previous observations from resting positron emission tomography studies and further elucidate the association between hypoactive rostral cingulate and nonresponsiveness to treatment in depression.

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Citations

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Research works printed but not linked: 2

  1. Andreasen, 1995, Remembering the past, Am J Psychiatry, 275, 1576
  2. Brammer, 1997, Generic brain activation mapping in fMRI, Magn Res Imaging, 15, 736

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Metadata

Authors
Kumari, V., Mitterschiffthaler, M. T., Teasdale, J. D., Malhi, G. S., Brown, R. G., Giampietro, V., Brammer, M. J., Poon, L., Simmons, A., Williams, S. C. R., Checkley, S. A., & Sharma, T.
Affiliations
  • King's College London (GB)
  • MRC Cognition and Brain Sciences Unit (GB)
  • UNSW Sydney (AU)
Corresponding author
Sharma, Tonmoy
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2003-10
Volume
54
Issue
8
Pages
777-791
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(02)01785-7
OpenAlex
W2048350205
Cited by
166
References
71
Citations by year
2025: 5 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 10 · 2018: 7 · 2017: 4 · 2016: 3 · 2015: 12 · 2014: 3 · 2013: 5 · 2012: 10
FWCI
7.50
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
treatment-resistant depression, rostral anterior cingulate cortex, medial prefrontal cortex, hippocampus, subgenual cingulate, striatum, parahippocampal gyrus, inferior frontal gyrus, brainstem
MeSH terms
Adult, Affect, Antidepressive Agents, Brain, Cognition Disorders, Depressive Disorder, Major, Major Depressive Disorder, Drug Resistance, Female, Humans, Magnetic Resonance Imaging, Middle Aged

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