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Cited by 760

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

The anatomy of mood disorders—review of structural neuroimaging studies

Open access
Soares, Jair C., Mann, J. John·1997·Biological Psychiatry
DOI 10.1016/s0006-3223(96)00006-6
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Abstract

The structural neuroimaging findings in mood disorders were reviewed, to evaluate evidence for a neuroanatomic model of pathophysiology, involving the prefrontal cortex, the basal ganglia, the amygdala-hippocampus complex, thalamus, and connections among these structures. Global atrophy is not consistently found. The best replicated finding is an increased rate of white matter and periventricular hyperintensities. A smaller frontal lobe, cerebellum, caudate, and putamen appear present in unipolar depression. A larger third ventricle, and smaller cerebellum and perhaps temporal lobe appear present in bipolar disorder. These localized structural changes involve regions that may be critical in the pathogenesis of mood disorders. Generalized and localized anatomic alterations may be related to age or vascular disease. The clinical and biological correlates of these changes need to be investigated to allow development of a more complete model of pathophysiology of mood disorders.

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Metadata

Authors
Soares, J. C., & Mann, J. J.
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1997-01
Volume
41
Issue
1
Pages
86-106
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(96)00006-6
OpenAlex
W1988021126
Cited by
760
References
12
FWCI
24.47
Type
journal article
Language
en
Open access
hybrid

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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