Subcortical hyperintensities on magnetic resonance imaging: clinical correlates and prognostic significance in patients with severe depression
Abstract
In 39 hospital inpatients with severe primary depressive disorders, we evaluated the relationships between subcortical hyperintensities on magnetic resonance imaging (MRI) and clinical features, neuropsychological impairment and response to standard therapies. Both white matter and gray nuclei lesions were associated with older age and the absence of a family history of affective disorder. White matter hyperintensities were also associated with onset of first affective episode after the age of 50 years and impaired psychomotor speed. Most importantly, the severity of white matter hyperintensities predicted a poorer response to treatment (r = -0.44, p < .01). Negative correlations of the same order were detected in those (n = 20) who received electroconvulsive therapy (r = -0.42, p = .06) and those (n = 19) who received pharmacotherapy alone (r = -.49, p < .05). This study provides preliminary evidence supporting the clinical and prognostic significance of extensive white matter hyperintensities in patients with severe depression.
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Frodl, T., Jäger, M., Born, C., Ritter, S., Kraft, E., Zetzsche, T., Bottlender, R., Leinsinger, G., Reiser, M., Möller, H.-J., et al. (2008) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.04.012 · Cited by 57 · see citing works
Relationship of Age, Age at Onset, and Sex to Depression in Older Adults
Lavretsky, H., Lesser, I. M., Wohl, M., & Miller, B. L. (1998) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-199808000-00007 · Cited by 56 · see citing works
- Authors
- Hickie, I., Scott, E., Mitchell, P., Wilhelm, K., Austin, M.-P., & Bennett, B.
- Affiliations
- UNSW Sydney (AU)
- Corresponding author
- Hickie, Ian
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1995-02
- Volume
- 37
- Issue
- 3
- Pages
- 151-160
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2066096066
- Cited by
- 398
- References
- 57
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 7 · 2013: 17 · 2012: 12
- FWCI
- 12.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- subcortical hyperintensities, white matter hyperintensities, severe depression, treatment response, prognostic factors, electroconvulsive therapy, pharmacotherapy, psychomotor speed, family history of affective disorder
- MeSH terms
- Activities of Daily Living, Adult, Aged, Aged, 80 and over, Antidepressive Agents, Basal Ganglia, Bipolar Disorder, Brain Damage, Chronic, Cerebral Cortex, Depressive Disorder, Electroconvulsive Therapy, Female, Humans, Limbic System, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Patient Admission, Treatment Outcome, Neurocognitive Disorders
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