Cited by 298Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Neurotransmitter interactions in schizophrenia–therapeutic implications

Carlsson, Arvid, Waters, Nicholas, Carlsson, Maria L·1999·Biological Psychiatry

Abstract

The search for new and improved antipsychotic agents has escalated during the past five years. The era of searching for non-toxic copies of clozapine has been followed by several different lines of research, some of which pursue the traditional dopamine track, although at a higher level of sophistication, whereas others focus on other neurotransmitters, such as serotonin and glutamate. Emerging knowledge about the interactions between different neurotransmitters in complex neurocircuits opens up possibilities for achieving antipsychotic activity by interfering with many different neurotransmitters. Most intriguing is the finding in animal experimental models, indicating that it should be possible to alleviate psychotic conditions by stabilizing rather than paralyzing neurocircuits, thus avoiding the risk of motor and mental side effects of the currently used drugs. Among these new classes dopaminergic stabilizers and 5-HT2A receptor antagonists seem to offer most promise at present. In a longer perspective, drugs interfering with glutamate function via different mechanisms may also turn out to be useful, especially in the control of negative symptoms.

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Registry

Crossref · 10.1016/s0006-3223(99)00117-1

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  • Glutamatergic frontal neurons influence dopaminergic neurotransmission in the VS via GABAergic neurons.

    “with studies reporting an influence of glutamatergic frontal neurons on dopaminergic neurotransmission in the VS via GABAergic neurons (Carlsson et al. 1999)”

    From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Carlsson et al. 1999

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Authors
Carlsson, A., Waters, N., & Carlsson, M. L.
Affiliations
University of Gothenburg (SE)
Corresponding author
Carlsson, Arvid
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1999-11
Volume
46
Issue
10
Pages
1388-1395
ISSN
0006-3223 (ISSN-L)
OpenAlex
W1978196348
Cited by
298
References
28
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 9 · 2017: 7 · 2016: 14 · 2015: 11 · 2014: 13 · 2013: 16 · 2012: 17
FWCI
1.51
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
schizophrenia, neurotransmitter interactions, antipsychotic drugs, dopamine, serotonin, glutamate, 5-HT2A receptor antagonist, negative symptoms, neural circuits, clozapine
MeSH terms
Animals, Disease Models, Animal, Dopamine, Humans, Interneurons, Schizophrenia, Serotonin, Thalamus, Antipsychotic Agents, Receptors, N-Methyl-D-Aspartate, Dizocilpine Maleate, Receptors, GABA, Neuroprotective Agents, Glutamic Acid

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