Dysfunction of ventral striatal reward prediction in schizophrenia
Abstract
Background Negative symptoms may be associated with dysfunction of the brain reward system in schizophrenia. We used functional magnetic resonance imaging (fMRI) to assess the BOLD response in the ventral striatum of unmedicated schizophrenics during presentation of reward-indicating and loss-indicating stimuli.Methods A total of 10 schizophrenic men (7 never medicated, 3 unmedicated for at least 2 years) and 10 age-matched healthy male volunteers participated in an incentive monetary delay task, in which visual cues predicted that a rapid response to a subsequent target stimulus would result either in monetary gain or loss or would have no consequence.Results Compared to healthy controls, unmedicated schizophrenics showed reduced ventral striatal activation during the presentation of reward-indicating cues. Decreased activation of the left ventral striatum was inversely correlated with the severity of negative (and trendwise positive) symptoms.Discussion Reduced activation in one of the central areas of the brain reward system, the ventral striatum, was correlated with the severity of negative symptoms in medication-free schizophrenics. In unmedicated schizophrenic patients, a high striatal dopamine turnover may increase the "noise" in the reward system, thus interfering with the neuronal processing of reward-predicting cues by phasic dopamine release. This, in turn, may contribute to negative symptoms as such as anhedonia, apathy, and loss of drive and motivation.
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A large number of fMRI studies indicate that midbrain and striatal responses to rewarding and to neutral outcomes are altered in patients with psychosis and that these alterations are associated with positive and negative symptoms.
“A large number of fMRI studies indicate that midbrain and striatal responses to rewarding and to neutral outcomes are altered in patients with psychosis (29-42) and that these alterations are associated with positive and negative symptoms.”
From Aberrant Salience, Information Processing, and Dopaminergic Signaling in People at Clinical High Risk for Psychosis (2020) · cites this paper as [32]
There is evidence of inverse relations between negative symptoms and NAc activation during reward anticipation and between lateral PFC activation during reward outcomes in schizophrenia.
“There is also evidence of inverse relations between negative symptoms and NAc activation during reward anticipation [416,420,422] and between lateral PFC activation during reward outcomes [420].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [422]
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- Authors
- Juckel, G., Schlagenhauf, F., Koslowski, M., Wüstenberg, T., Villringer, A., Knutson, B., Wrase, J., & Heinz, A.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- University of Göttingen (DE)
- Stanford University (US)
- Corresponding author
- Heinz, Andreas
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 29
- Issue
- 2
- Pages
- 409-416
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2084331056
- Cited by
- 578
- References
- 54
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 12 · 2023: 17 · 2022: 12 · 2021: 20 · 2020: 22 · 2019: 24 · 2018: 33 · 2017: 33 · 2016: 53 · 2015: 66 · 2014: 46 · 2013: 30 · 2012: 37
- FWCI
- 13.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- GRO (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- schizophrenia, ventral striatum, reward prediction, negative symptoms, brain reward system, dopamine turnover, anhedonia, unmedicated patients, BOLD signal
- MeSH terms
- Adult, Humans, Magnetic Resonance Imaging, Male, Motivation, Psychiatric Status Rating Scales, Reward, Schizophrenia, Schizophrenic Psychology, Neostriatum
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