The DOI matches its Crossref record; 107 of the 110 references it cites were found in a registry or an index.
The role of corticotropin-releasing factor–norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress
Abstract
Naturally occurring variations in maternal care in early postnatal life are associated with the development of individual differences in behavioral and hypothalamic-pituitary-adrenal responses to stress in the rat. These effects appear to be mediated by the influence of maternal licking and grooming on the development of central corticotropin-releasing factor (CRF) systems, which regulate the expression of behavioral, endocrine, and autonomic responses to stress through activation of forebrain noradrenergic systems. These findings provide a neurobiologic basis for the observed relationship between early life events and health in adulthood. In more recent studies, we explored the behavioral transmission of individual differences in stress reactivity, and thus, vulnerability to stress-induced illness, across generations.
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“The relationship between the quality of the early social environment and health in adulthood appears to be, in part, mediated by the development of individual differences in neural systems that underlie the expression of behavioral and endocrine responses to stress.26-30”
From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [28]
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Cites
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Cited by
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Metadata
- Authors
- Francis, D. D., Caldji, C., Champagne, F., Plotsky, P. M., & Meaney, M. J.
- Affiliations
- Douglas Mental Health University Institute (CA)
- Emory University (US)
- Corresponding author
- Meaney, Michael J
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 46
- Issue
- 9
- Pages
- 1153-1166
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2047908047
- Cited by
- 380
- References
- 110
- Citations by year
- 2026: 17 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 14 · 2021: 6 · 2020: 6 · 2019: 13 · 2018: 7 · 2017: 4 · 2016: 14 · 2015: 9 · 2014: 13 · 2013: 14 · 2012: 15
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- corticotropin-releasing factor, noradrenergic system, maternal care, early life experience, stress reactivity, hypothalamic-pituitary-adrenal axis, individual differences, intergenerational transmission
- MeSH terms
- Animals, Corticotropin-Releasing Hormone, Disease Susceptibility, Female, Handling, Psychological, Hypothalamo-Hypophyseal System, Male, Maternal Behavior, Norepinephrine, Pituitary-Adrenal System, Stress, Psychological, Genetic Predisposition to Disease, Rats
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