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Cited by 380Stress Responses and CortisolNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

The DOI matches its Crossref record; 107 of the 110 references it cites were found in a registry or an index.

The role of corticotropin-releasing factor–norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress

Francis, Darlene D, Caldji, Christian, Champagne, Frances, Plotsky, Paul M, Meaney, Michael J·1999·Biological Psychiatry
DOI 10.1016/s0006-3223(99)00237-1
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Abstract

Naturally occurring variations in maternal care in early postnatal life are associated with the development of individual differences in behavioral and hypothalamic-pituitary-adrenal responses to stress in the rat. These effects appear to be mediated by the influence of maternal licking and grooming on the development of central corticotropin-releasing factor (CRF) systems, which regulate the expression of behavioral, endocrine, and autonomic responses to stress through activation of forebrain noradrenergic systems. These findings provide a neurobiologic basis for the observed relationship between early life events and health in adulthood. In more recent studies, we explored the behavioral transmission of individual differences in stress reactivity, and thus, vulnerability to stress-induced illness, across generations.

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Crossref · 10.1016/s0006-3223(99)00237-1

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107 of 107 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 14

  1. Barnett, 1967, Rats, Sci Am, 21, 79
  2. Caldji C, Diorio J, Francis DD, Sharma S, Meaney MJ (in press): Maternal care during infancy regulates the expression of GABAergic receptor subunit expression.
  3. Caldji, 1999, Multiple central benzodiazepine/GABAA receptor subunits regulated by maternal behavior in infancy, Soc Neurosci Abstr, 25, 616
  4. Fleming, 1988, Factors influencing maternal responsiveness in humans, Psychoneuroendocrinology, 13, 189, 10.1016/0306-4530(88)90014-5 · DOI
  5. Francis, 1998, Variations in maternal care form the basis for a non-genomic mechanism of inter-generational transmission of individual differences in behavioral and endocrine responses to stress, Soc Neurosci Abs, 24, 452
  6. Gray TS (1990): The organization and possible function of amygdaloid corticotropin-releasing factor pathways. In: De Souza EB, Nemeroff CB, editors. Corticotropin-Releasing Factor: Basic and Clinical Studies of a Neuropeptide. Boca Raton, FL: CRC Press, 53–68.
  7. Liu D, Caldji C, Sharma S, Plotsky PM, Meaney MJ (in press): The effects of early life events on in vivo release of norepinephrine in the paraventricular nucleus of the hypothalamus and hypothalamic–pituitary–adrenal responses during stress. J Neuroendocrinol.
  8. Meaney MJ (in press): Early experience effects on HPA function—a basis for individual differences. In: McEwen BS and Steller E, editors. Handbook of Physiology: Coping with the Environment. New York: Oxford University Press.
  9. Nemeroff, 1996, The corticotropin-releasing factor (CRF) hypothesis of depression, Mol Psychiatry, 1, 336
  10. Owens, 1991, The effects of alprazoplam on corticotropin-releasing factor neurons in the rat brain, J Pharmacol Exp Therap, 258, 349
  11. Pearson, 1997, The effect of postnatal environment on stress-induced changes in hippocampal FOS-like immunoreactivity in adult rats, Soc Neurosci Abst, 23, 1849
  12. Plotsky PM, Meaney MJ (in press): Early environment alters hypothalamic–pituitary–adrenal responses to a wide range of stressful stimuli. Proc Natl Acad Sci USA.
  13. Scarr, 1983, How people make their own environments, Child Dev, 54, 424
  14. Zarrow, 1972, Handling in infancy, Proc Soc Exp Biol Med, 356, 141

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Metadata

Authors
Francis, D. D., Caldji, C., Champagne, F., Plotsky, P. M., & Meaney, M. J.
Affiliations
  • Douglas Mental Health University Institute (CA)
  • Emory University (US)
Corresponding author
Meaney, Michael J
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1999-11
Volume
46
Issue
9
Pages
1153-1166
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(99)00237-1
OpenAlex
W2047908047
Cited by
380
References
110
Citations by year
2026: 17 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 14 · 2021: 6 · 2020: 6 · 2019: 13 · 2018: 7 · 2017: 4 · 2016: 14 · 2015: 9 · 2014: 13 · 2013: 14 · 2012: 15
FWCI
1.32
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
corticotropin-releasing factor, noradrenergic system, maternal care, early life experience, stress reactivity, hypothalamic-pituitary-adrenal axis, individual differences, intergenerational transmission
MeSH terms
Animals, Corticotropin-Releasing Hormone, Disease Susceptibility, Female, Handling, Psychological, Hypothalamo-Hypophyseal System, Male, Maternal Behavior, Norepinephrine, Pituitary-Adrenal System, Stress, Psychological, Genetic Predisposition to Disease, Rats

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