Cited by 380Stress Responses and CortisolNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

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The role of corticotropin-releasing factor–norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress

Francis, Darlene D, Caldji, Christian, Champagne, Frances, Plotsky, Paul M, Meaney, Michael J·1999·Biological Psychiatry

DOI 10.1016/s0006-3223(99)00237-1

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Abstract

Naturally occurring variations in maternal care in early postnatal life are associated with the development of individual differences in behavioral and hypothalamic-pituitary-adrenal responses to stress in the rat. These effects appear to be mediated by the influence of maternal licking and grooming on the development of central corticotropin-releasing factor (CRF) systems, which regulate the expression of behavioral, endocrine, and autonomic responses to stress through activation of forebrain noradrenergic systems. These findings provide a neurobiologic basis for the observed relationship between early life events and health in adulthood. In more recent studies, we explored the behavioral transmission of individual differences in stress reactivity, and thus, vulnerability to stress-induced illness, across generations.

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Authors: Francis, D. D., Caldji, C., Champagne, F., Plotsky, P. M., & Meaney, M. J.
Affiliations: Douglas Mental Health University Institute (CA)
Emory University (US)
Corresponding author: Meaney, Michael J
ORCID: Champagne, Frances
Meaney, Michael J
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 1999-11
Volume: 46
Issue: 9
Pages: 1153-1166
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/s0006-3223(99)00237-1
OpenAlex: W2047908047
Cited by: 380
References: 110
Citations by year: 2026: 17 · 2025: 5 · 2024: 2 · 2023: 7 · 2022: 14 · 2021: 6 · 2020: 6 · 2019: 13 · 2018: 7 · 2017: 4 · 2016: 14 · 2015: 9 · 2014: 13 · 2013: 14 · 2012: 15
FWCI: 1.32
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: corticotropin-releasing factor, noradrenergic system, maternal care, early life experience, stress reactivity, hypothalamic-pituitary-adrenal axis, individual differences, intergenerational transmission
MeSH terms: Animals, Corticotropin-Releasing Hormone, Disease Susceptibility, Female, Handling, Psychological, Hypothalamo-Hypophyseal System, Male, Maternal Behavior, Norepinephrine, Pituitary-Adrenal System, Stress, Psychological, Genetic Predisposition to Disease, Rats

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The role of corticotropin-releasing factor–norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress

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