The DOI matches its Crossref record; 101 of the 107 references it cites were found in a registry or an index.
Neural circuits mediating stress
Abstract
Stress has been linked to the pathophysiology and pathogenesis of mood and anxiety disorders. Over the past few years, our understanding of the brain and neuroendocrine circuits that are linked to the stress response have increased dramatically. This article reviews a series of animal and human studies aimed at understanding what are the pathways by which stress is perceived, processed, and transduced into a neuroendocrine response. We focus on the classic stress circuit: the limbic-hypothalamic-pituitary-adrenal (LHPA) axis. These studies indicate that the LHPA stress circuit is a complex system with multiple control mechanisms and that these mechanisms are altered in pathological states, such as chronic stress and depression. These studies also suggest that the interactions between the LHPA and other neurotransmitters, such as serotonin, may provide the neurobiological substrate by which stress may affect mood.
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“Acute stress activates the hypothalamic-pituitaryadrenal (HPA) axis, leading to release of glucocorticoids such as cortisol (Lopez et al, 1999;Chrousos et al, 2009), and the sympathetic-adrenomedullary system (SAM), leading to secretion of catecholamines (Lopez et al, 1999;Chrousos et al, 2009).”
From Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans (2012) · cites this paper as Lopez et al, 1999
Citations
Cites
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Self-citation
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Sorted by citations
Neurobiology of emotion perception I: the neural basis of normal emotion perception
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00168-9 · Cited by 2,173
Salivary cortisol as a biomarker in stress research
Hellhammer, D. H., Wüst, S., & Kudielka, B. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.026 · Cited by 1,925
The cortisol awakening response (CAR): Facts and future directions
Fries, E., Dettenborn, L., & Kirschbaum, C. (2009) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2008.03.014 · Cited by 1,188
Investigating emotion with music: An fMRI study
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Metadata
- Authors
- López, J. F., Akil, H., & Watson, S. J.
- Affiliations
- University of Michigan (US)
- Corresponding author
- López, Juan F
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 46
- Issue
- 11
- Pages
- 1461-1471
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2092002730
- Cited by
- 373
- References
- 107
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 7 · 2021: 12 · 2020: 6 · 2019: 3 · 2018: 10 · 2017: 7 · 2016: 8 · 2015: 9 · 2014: 14 · 2013: 22 · 2012: 10
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k21mh001164-05)
- National Institute of Mental Health (MH 42251, P01MH042251, MH-01164)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- stress, neuroendocrine stress response, chronic stress, depression, mood disorders, anxiety disorders, serotonin, perceived stress, neural circuits
- MeSH terms
- Brain, Child, Child Development, Humans, Nerve Net, Stress, Psychological
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