Cited by 373Stress Responses and CortisolNeuropeptides and Animal PhysiologyMemory and Neural Mechanisms

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Neural circuits mediating stress

López, Juan F, Akil, Huda, Watson, Stanley J·1999·Biological Psychiatry

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Abstract

Stress has been linked to the pathophysiology and pathogenesis of mood and anxiety disorders. Over the past few years, our understanding of the brain and neuroendocrine circuits that are linked to the stress response have increased dramatically. This article reviews a series of animal and human studies aimed at understanding what are the pathways by which stress is perceived, processed, and transduced into a neuroendocrine response. We focus on the classic stress circuit: the limbic-hypothalamic-pituitary-adrenal (LHPA) axis. These studies indicate that the LHPA stress circuit is a complex system with multiple control mechanisms and that these mechanisms are altered in pathological states, such as chronic stress and depression. These studies also suggest that the interactions between the LHPA and other neurotransmitters, such as serotonin, may provide the neurobiological substrate by which stress may affect mood.

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Authors: López, J. F., Akil, H., & Watson, S. J.
Affiliations: University of Michigan (US)
Corresponding author: López, Juan F
ORCID: Akil, Huda
Watson, Stanley J
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 1999-12
Volume: 46
Issue: 11
Pages: 1461-1471
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/s0006-3223(99)00266-8
OpenAlex: W2092002730
Cited by: 373
References: 107
Citations by year: 2026: 1 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 7 · 2021: 12 · 2020: 6 · 2019: 3 · 2018: 10 · 2017: 7 · 2016: 8 · 2015: 9 · 2014: 14 · 2013: 22 · 2012: 10
FWCI: 1.42
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k21mh001164-05)
National Institute of Mental Health (MH 42251, P01MH042251, MH-01164)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: stress, neuroendocrine stress response, chronic stress, depression, mood disorders, anxiety disorders, serotonin, perceived stress, neural circuits
MeSH terms: Brain, Child, Child Development, Humans, Nerve Net, Stress, Psychological

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