Cited by 373Stress Responses and CortisolNeuropeptides and Animal PhysiologyMemory and Neural Mechanisms

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Neural circuits mediating stress

López, Juan F, Akil, Huda, Watson, Stanley J·1999·Biological Psychiatry

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Abstract

Stress has been linked to the pathophysiology and pathogenesis of mood and anxiety disorders. Over the past few years, our understanding of the brain and neuroendocrine circuits that are linked to the stress response have increased dramatically. This article reviews a series of animal and human studies aimed at understanding what are the pathways by which stress is perceived, processed, and transduced into a neuroendocrine response. We focus on the classic stress circuit: the limbic-hypothalamic-pituitary-adrenal (LHPA) axis. These studies indicate that the LHPA stress circuit is a complex system with multiple control mechanisms and that these mechanisms are altered in pathological states, such as chronic stress and depression. These studies also suggest that the interactions between the LHPA and other neurotransmitters, such as serotonin, may provide the neurobiological substrate by which stress may affect mood.

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A Syndrome produced by Diverse Nocuous Agents
Selye, H. (1936) · Nature · doi:10.1038/138032a0 · Cited by 3,967
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580
THE GENERAL ADAPTATION SYNDROME AND THE DISEASES OF ADAPTATION1
Selye, H. (1946) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-6-2-117 · Cited by 2,296
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors
Pazos, Á., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90856-x · Cited by 1,855
Transduction of psychosocial stress into the neurobiology of recurrent affective disorder
(1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.8.999 · Cited by 1,848
Childhood adversity and adult psychiatric disorder in the US National Comorbidity Survey
KESSLER, R. C., DAVIS, C. G., & KENDLER, K. S. (1997) · Psychological Medicine · doi:10.1017/s0033291797005588 · Cited by 1,298
Corticosteroid inhibition of acth secretion
KELLER-WOOD, M. E., & DALLMAN, M. F. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-1 · Cited by 1,219
Pattern and time course of immediate early gene expression in rat brain following acute stress
Cullinan, W. E., Herman, J. P., Battaglia, D. F., Akil, H., & Watson, S. J. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00355-9 · Cited by 1,056
Self-citation
Antidepressants and Hypothalamic-Pituitary-Adrenocortical Regulation
HOLSBOER, F., & Barden, N. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-2-187 · Cited by 860
Fear and the brain: where have we been, and where are we going?
LeDoux, J. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00282-0 · Cited by 782
Regulation of Serotonin1A, Glucocorticoid, and Mineralocorticoid Receptor in Rat and Human Hippocampus: Implications for the Neurobiology of Depression
López, J. F., Chalmers, D. T., Little, K. Y., & Watson, S. J. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00484-8 · Cited by 700
Self-citation
Serotonin receptors in the human brain—III. Autoradiographic mapping of serotonin-1 receptors
Pazos, Á., Probst, A., & Palacios, J. M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90326-5 · Cited by 684
Increased Numbers of Corticotropin-Releasing Hormone Expressing Neurons in the Hypothalamic Paraventricular Nucleus of Depressed Patients
Raadsheer, F. C., Hoogendijk, W. J. G., Stam, F. C., Tilders, F. J. H., & Swaab, D. F. (2008) · Neuroendocrinology · doi:10.1159/000126778 · Cited by 667
Regulation of ACTH Secretion: Variations on a Theme of B
DALLMAN, M. F., AKANA, S. F., CASCIO, C. S., DARLINGTON, D. N., JACOBSON, L., & LEVIN, N. (1987) · Proceedings of the 1986 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571143-2.50010-1 · Cited by 655
Textbook of psychopharmacology
Edwards, G. (1975) · Nature · doi:10.1038/258648b0 · Cited by 583
Psychiatric Sequelae of Posttraumatic Stress Disorder in Women
Breslau, N. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830130087016 · Cited by 566
Anatomy of the Serotonergic Systema
Törk, I. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb16870.x · Cited by 557
Stress-restress: Effects on ACTH and fast feedback
Liberzon, I., Krstov, M., & Young, E. A. (1997) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(97)00044-9 · Cited by 556
Reduced Corticotropin Releasing Factor Binding Sites in the Frontal Cortex of Suicide Victims
Nemeroff, C. B. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800300075009 · Cited by 555
Untitled work
(1996) · PubMed · Cited by 547
Are different parts of the extended amygdala involved in fear versus anxiety?
Davis, M. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00288-1 · Cited by 545
Ventral subicular interaction with the hypothalamic paraventricular nucleus: Evidence for a relay in the bed nucleus of the stria terminalis
Cullinan, W. E., Herman, J. P., & Watson, S. J. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903320102 · Cited by 541
Self-citation
Mapping of Glucocorticoid Receptor Immunoreactive Neurons in the Rat Tel- and Diencephalon Using a Monoclonal Antibody against Rat Liver Glucocorticoid Receptor*
Fuxé, K., Wikström, A., Okret, S., Agnati, L. F., Härfstrand, A., Yu, Z., Granholm, L., Zoli, M., Vale, W., & Gustafsson, J.-Α. (1985) · Endocrinology · doi:10.1210/endo-117-5-1803 · Cited by 507
Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis
Herman, J. P., Schafer, M., Young, E. A., Thompson, R. C., DOUGLASS, J. O., Akil, H., & Watson, S. J. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-09-03072.1989 · Cited by 467
Self-citation
Regulatory Changes in Neuroendocrine Stress-Integrative Circuitry Produced by a Variable Stress Paradigm
Herman, J. P., Adams, D., & Prewitt, C. M. (2008) · Neuroendocrinology · doi:10.1159/000126839 · Cited by 462
Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims
Arango, V., Underwood, M. D., Gubbi, A., & Mann, J. J. (1995) · Brain Research · doi:10.1016/0006-8993(95)00523-s · Cited by 458
Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression
Raadsheer, F. C., van Heerikhuize, J. J., Lucassen, P. J., Hoogendijk, W. J. G., Tilders, F. J. H., & Swaab, D. F. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.9.1372 · Cited by 417
Corticotrophin-releasing factor receptors: from molecular biology to drug design
Chalmers, D. T., Lovenberg, T. W., Grigoriadis, D. E., Behan, D. P., & Souza, E. B. D. (1996) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(96)81594-x · Cited by 398
Childhood Parental Loss and Adult Psychopathology in Women
Kendler, K. S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820020029004 · Cited by 394
The Neurobiology of Depression
Nemeroff, C. B. (1998) · Scientific American · doi:10.1038/scientificamerican0698-42 · Cited by 381
Stressful Life Events and Major Depression: Risk Period, Long-Term Contextual Threat, and Diagnostic Specificity
KENDLER, K. S., KARKOWSKI, L. M., & PRESCOTT, C. A. (1998) · The Journal of Nervous & Mental Disease · doi:10.1097/00005053-199811000-00001 · Cited by 380
Neuronal Circuit Regulation of the Hypothalamo-Pituitary-Adrenocortical Stress Axis
Herman, J. P., Prewitt, C. M.-F., & Cullinan, W. E. (1996) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v10.i3-4.50 · Cited by 357
Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors
Pazos, A., Probst, A., & Palacios, J. M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90327-7 · Cited by 355
What is stress?
Selye, H. (1956) · PubMed · Cited by 341
Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications.
Brady, L. S., Whitfield, H. J., Fox, R. J., Gold, P. W., & Herkenham, M. A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115086 · Cited by 338
Selective serotonin reuptake inhibitors: a review of efficacy and tolerability in depression
Mace, S., & Taylor, D. M. (2000) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.1.5.917 · Cited by 315
In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation
WEBSTER, E. L., Lewis, D. B., Torpy, D. J., Zachman, E. K., Rice, K. C., & Chrousos, G. P. (1996) · Endocrinology · doi:10.1210/endo.137.12.8940412 · Cited by 311
Differential Regulation of Hippocampal Glucocorticoid Receptors mRNA and Fast Feedback: Relevance to Post‐Traumatic Stress Disorder
Liberzon, López, Flagel, Vázquez, & Young (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00288.x · Cited by 308
Loss of Glucocorticoid Fast Feedback in Depression
Young, E. A. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810320017003 · Cited by 299
Amygdaloid CRF Pathways: Role in Autonomic, Neuroendocrine, and Behavioral Responses to Stress
Gray, T. S. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb49922.x · Cited by 288
Serotonin receptor binding in a colony model of chronic social stress
McKittrick, C. R., Blanchard, D. C., Blanchard, R. J., McEwen, B. S., & Sakai, R. R. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00152-s · Cited by 281
A Functional Neuroanatomy of Anxiety and Fear: Implications for the Pathophysiology and Treatment of Anxiety Disorders
Deutch, A. Y., & Charney, D. S. (1996) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v10.i3-4.70 · Cited by 259
Effects of Corticotropin-Releasing Factor on Brain Serotonergic Activity
Price, M. L., Curtis, A., Kirby, L., Valentino, R., & Lucki, I. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00197-8 · Cited by 240
Distinct mechanisms underlie activation of hypothalamic neurosecretory neurons and their medullary catecholaminergic afferents in categorically different stress paradigms.
Li, H.-Y., Ericsson, A. B., & Sawchenko, P. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2359 · Cited by 235
Involvement of the Bed Nucleus of the Stria Terminalis in Tonic Regulation of Paraventricular Hypothalamic CRH and AVP mRNA Expression
Herman, J. P., Cullinan, W. E., & Watson, S. J. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00604.x · Cited by 235
Self-citation
Neuroendocrine and Behavioral Responses and Brain Pattern of c‐fos Induction Associated with Audiogenic Stress
Campeau, S., & Watson, S. J. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.00593.x · Cited by 227
Self-citation
Stress: Neurobiology and neuroendocrinology
Wolf, S. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90218-a · Cited by 222
Chapter 12 Regulation of multiple peptides in CRF parvocellular neurosecretory neurons: implications for the stress response
Swanson, L. W., Sawchenko, P. E., & Lind, R. W. (1986) · Progress in brain research · doi:10.1016/s0079-6123(08)60238-1 · Cited by 220
Brain circuits in panic disorder
Coplan, J. D., & Lydiard, R. B. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00300-x · Cited by 195
Biochemical evidence for glutamate as a transmitter in hippocampal efferents to the basal forebrain and hypothalamus in the rat brain
Walaas, I., & Fonnum, F. (1980) · Neuroscience · doi:10.1016/0306-4522(80)90088-3 · Cited by 190
Serotonergic Stimulation of Pituitary-Adrenocortical Function in Rats
Fuller, R. W. (2008) · Neuroendocrinology · doi:10.1159/000123142 · Cited by 187
Stress: Neurobiology and Neuroendocrinology
Brown, M. R., Koob, G. F., & RIVIER, C. L. (1990) · Medical Entomology and Zoology · Cited by 185
The involvement of serotonin in regulation of pituitary-adrenocortical function.
Rw, F. (1992) · PubMed · Cited by 181
Textbook of Psychopharmacology
(1995) · Nature Medicine · doi:10.1038/nm0895-834 · Cited by 178
Corticotropin-Releasing Hormone
Taylor, A. L., & Fishman, L. M. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807283190405 · Cited by 175
Life events and affective disorder: replications and limitations.
Brown, G. W. (1993) · Psychosomatic Medicine · doi:10.1097/00006842-199305000-00003 · Cited by 175
Frontiers in neuroendocrinology
(1986) · General and Comparative Endocrinology · doi:10.1016/0016-6480(86)90174-7 · Cited by 173
Long-Term Intracerebroventricular Infusion of Corticotropin-Releasing Hormone Alters Neuroendocrine, Neurochemical, Autonomic, Behavioral, and Cytokine Responses to a Systemic Inflammatory Challenge
Linthorst, A. C. E., Flachskamm, C., Hopkins, S. J., Hoadley, M. E., Labeur, M. S., Holsboer, F., & Reul, J. M. H. M. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04448.1997 · Cited by 162
Converging GABA‐ and glutamate‐immunoreactive axons make synaptic contact with identified hypothalamic neurosecretory neurons
Decavel, C., & van den Pol, A. N. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903160109 · Cited by 145
Selective forebrain fiber tract lesions implicate ventral hippocampal structures in tonic regulation of paraventricular nucleus corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA expression
Herman, J. P., Cullinan, W. E., Young, E. A., Akil, H., & Watson, S. J. (1992) · Brain Research · doi:10.1016/0006-8993(92)91680-d · Cited by 144
Self-citation
Topographical distribution of dorsal and median raphe neurons projecting to motor, Sensorimotor, and visual cortical Areas in the rat
Waterhouse, B. D., Mihailoff, G. A., Baack, J. C., & Woodward, D. J. (1986) · Journal of Comparative Neurology · doi:10.1002/cne.902490403 · Cited by 136
Life Events and the Research Diagnostic Criteria Endogenous Subtype
Frank, E. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950070011005 · Cited by 135
Effects of monoamine oxidase A inhibition on barrel formation in the mouse somatosensory cortex: Determination of a sensitive developmental period
Vitalis, T., Cases, O., Callebert, J., Launay, J., Price, D. J., Seif, I., & Gaspar, P. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980406)393:2 · Cited by 131
Increased adrenal weight in victims of violent suicide
Dorovini‐Zis, K., & Zis, A. P. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.9.1214 · Cited by 127
Corticosterone binding to hippocampus: Immediate and delayed influences of the absence of adrenal secretion
McEwen, B. S., Wallach, G., & Magnus, C. (1974) · Brain Research · doi:10.1016/0006-8993(74)90321-7 · Cited by 115
Selective Serotonin Reuptake Inhibitors
Mozayani, M. (2011) · Humana Press eBooks · doi:10.1007/978-1-61779-222-9_6 · Cited by 113
Neurotransmitter modulation of corticotropin releasing factor secretion into the hypophysial-portal circulation
Plotsky, P. M., Otto, S., & Sutton, S. W. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90211-6 · Cited by 111
Postmortem Findings in Suicide Victims. Implications for in Vivo Imaging Studiesa
ARANGO, V., UNDERWOOD, M. D., & MANN, J. J. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb52365.x · Cited by 106
The Hypothalamic-Pituitary-Adrenal System in Depression
Heuser, I. (1998) · Pharmacopsychiatry · doi:10.1055/s-2007-979288 · Cited by 106
Raphe Nuclei and the Serotonergic System
Törk, I., & Hornung, J. (1990) · Elsevier eBooks · doi:10.1016/b978-0-12-547625-6.50035-0 · Cited by 104
Regulation of 5‐HT Receptors and the Hypothalamic‐Pituitary‐Adrenal Axis
López, J. F., Vázquez, D. M., Chalmers, D. T., & Watson, S. J. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb52357.x · Cited by 102
Self-citation
Chronic electroconvulsive shock treatment elicits up-regulation of CRF and AVP mRNA in select populations of neuroendocrine neurons
Herman, J. P., Schäfer, M. K.-H., Sladek, C. D., Day, R. W., Young, E. A., Akil, H., & Watson, S. J. (1989) · Brain Research · doi:10.1016/0006-8993(89)90641-0 · Cited by 100
Self-citation
Localization and Quantification of Pro-Opiomelanocortin mRNA and Glucocorticoid Receptor mRNA in Pituitaries of Suicide Victims
López, J. F., Palkovits, M., Arató, M., Mansour, A., Akil, H., & Watson, S. J. (2008) · Neuroendocrinology · doi:10.1159/000126266 · Cited by 97
Self-citation
Social Factors and Comorbidity of Depressive and Anxiety Disorders
Brown, G. W., Harris, T., & Eales, M. J. (1996) · The British Journal of Psychiatry · doi:10.1192/s0007125000298413 · Cited by 95
Central 5,7‐Dihydroxytryptamine Lesions Decrease Hippocampal Glucocorticoid and Mineralocorticoid Receptor Messenger Ribonucleic Acid Expression
Seckl, J. R., Dickson, K. L., & Fink, G. (1990) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1990.tb00659.x · Cited by 95
Effects of adrenalectomy and type I or type II glucocorticoid receptor activation on 5-HT1A and 5-HT2 receptor binding and 5-HT transporter mRNA expression in rat brain
Kuroda, Y., Watanabe, Y., Albeck, D. S., Hastings, N. B., & McEwen, B. S. (1994) · Brain Research · doi:10.1016/0006-8993(94)91916-x · Cited by 93
Serotonin Receptor Subtypes Involved in the Elevation of Serum Corticosterone Concentration in Rats by Direct- and Indirect-Acting Serotonin Agonists
Fuller, R. W., & Snoddy, H. D. (2008) · Neuroendocrinology · doi:10.1159/000125586 · Cited by 91
Biological therapies for posttraumatic stress disorder: an overview.
Davidson, J. R. T. (1997) · PubMed · Cited by 83
Life events and the 1-year prevalence of major depressive episode, generalized anxiety disorder, and panic disorder in a community sample
Newman, S. C., & Bland, R. C. (1994) · Comprehensive Psychiatry · doi:10.1016/0010-440x(94)90173-2 · Cited by 71
Psychological therapies for post-traumatic stress disorder
Adshead, G. M. J. (2000) · The British Journal of Psychiatry · doi:10.1192/bjp.177.2.144 · Cited by 70
Regulation of corticosteroid receptor gene expression in depression and antidepressant action.
Barden, N. (1999) · PubMed Central · Cited by 66
Pretranslational and Posttranslational Mechanisms for Regulatingβ-Endorphin- Adrenocorticotropin of the Anterior Pituitary Lobe*
Shiomi, H., Watson, S. J., Kelsey, J. E., & Akil, H. (1986) · Endocrinology · doi:10.1210/endo-119-4-1793 · Cited by 63
Self-citation
New developments in the treatment of obsessive-compulsive disorder.
Leonard, H. L. (1997) · PubMed · Cited by 60
Regulation of Hippocampal 5-HT1A Receptor Gene Expression by Dexamethasone
Chalmers, D. T., López, J. F., Vázquez, D. M., Akil, H., & Watson, S. J. (1994) · Neuropsychopharmacology · doi:10.1038/npp.1994.24 · Cited by 56
Self-citation
Distribution of glutamic acid decarboxylase messenger RNA-containing nerve cell populations of the male rat brain.
Ferraguti, F., Zoli, M., Aronsson, M., Agnati, L. F., Goldstein, M., Filer, D., & Fuxé, K. (1990) · PubMed · Cited by 56
Effect of acetylcholine and 5-hydroxytryptamine on the secretion of corticotrophin-releasing factor-41 and arginine vasopressin from the rat hypothalamus in vitro
Hillhouse, E. W., & Milton, N. G. N. (1989) · Journal of Endocrinology · doi:10.1677/joe.0.1220713 · Cited by 54
Colocalization of ionotropic glutamate receptor subunits with NADPH-diaphorase-containing neurons in the rat mesopontine tegmentum
Inglis, W. L., & Semba, K. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960422)368:1 · Cited by 49
Clinical Neuropharmacology of Hypothalamic Releasing Factors
Frohman, L. A. (1972) · New England Journal of Medicine · doi:10.1056/nejm197206292862606 · Cited by 48
The regulation of ACTH secretion.
Pg, S. (1969) · PubMed · Cited by 46
Pharmacotherapy of Panic Disorder: Proposed Guidelines for the Family Physician
Roy‐Byrne, P., Stein, M. B., Bystrisky, A., & Katon, W. J. (1998) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.11.4.282 · Cited by 44
Hypophysiotropic CRF Neurons Display a Sustained Immediate‐Early Gene Response to Chronic Stress but not to Adrenalectomy
Brown, E. R., & Sawchenko, P. E. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.00586.x · Cited by 41
Differential effect of subchronic dexamethasone treatment on serotonin-2 and β-adrenergic receptors in the rat cerebral cortex and hippocampus
Kuroda, Y., Mikuni, M., Nomura, N., & Takahashi, K. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90706-q · Cited by 39
Pharmacotherapy of panic disorder: differential efficacy from a clinical viewpoint.
den Boer, J. A. (1998) · PubMed · Cited by 39
POSSIBLE ROLE OF GAMMA-AMINOBUTYRIC ACID SYNTHESIS IN THE MECHANISM OF DEXAMETHASONE FEEDBACK ACTION
Ács, Z., & Stark, E. (1978) · Journal of Endocrinology · doi:10.1677/joe.0.0770137 · Cited by 34
[Regulation of ACTH secretion].
Ervin, S. (1978) · PubMed · Cited by 30
Pharmacotherapy of Panic Disorder
Judd, F. K., Norman, T. R., & Burrows, G. D. (1990) · International Review of Psychiatry · doi:10.3109/09540269009026609 · Cited by 13
Corticotropin-Releasing Hormone
Amano, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801028-0.00109-4 · Cited by 7
THE HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL (HPA) SYSTEM AND ANTI-DEPRESSIVE DRUG (AD) ACTION
Reul, J. M. H. M., Söder, M., & Holsboer, F. (1992) · Clinical Neuropharmacology · doi:10.1097/00002826-199201001-00303 · Cited by 3
Corticotropin releasing hormone: clinical endocrinology and implications for Cushing's disease and endogenous depression.
Rs, J., & Lopez, J. F. (1985) · PubMed · Cited by 3

Research works printed but not linked: 5

Chalmers, 1993, Molecular aspects of the stress axis and serotonergic function in depression, Clin Neurosci, 1, 122
Davidson, 1997, Biological therapies for post-traumatic stress disorders, J Clin Psychiatry, 58, 29
López, 1994, Effect of imipramine administration and swim stress on the hypothalamic pituitary adrenal axis, Endocrine, 2, 723
Nemeroff, 1996, The corticotropin-releasing factor (CRF) hypothesis of depression, Mol Psychiatry, 1, 336
Szafarczyk, 1980, Serotonin system and circadian rhythms of ACTH and corticosterone in rats, Am J Physiol, 239, E482

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See all 373

Authors: López, J. F., Akil, H., & Watson, S. J.
Affiliations: University of Michigan (US)
Corresponding author: López, Juan F
ORCID: Akil, Huda
Watson, Stanley J
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 1999-12
Volume: 46
Issue: 11
Pages: 1461-1471
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/s0006-3223(99)00266-8
OpenAlex: W2092002730
Cited by: 373
References: 107
Citations by year: 2026: 1 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 7 · 2021: 12 · 2020: 6 · 2019: 3 · 2018: 10 · 2017: 7 · 2016: 8 · 2015: 9 · 2014: 14 · 2013: 22 · 2012: 10
FWCI: 1.42
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k21mh001164-05)
National Institute of Mental Health (MH 42251, P01MH042251, MH-01164)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: stress, neuroendocrine stress response, chronic stress, depression, mood disorders, anxiety disorders, serotonin, perceived stress, neural circuits
MeSH terms: Brain, Child, Child Development, Humans, Nerve Net, Stress, Psychological

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