The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Introducing dielectrophoresis as a new force field for field-flow fractionation
Open accessAbstract
We present the principle of cell characterization and separation by dielectrophoretic field-flow fractionation and show preliminary experimental results. The operational device takes the form of a thin chamber in which the bottom wall supports an array of microelectrodes. By applying appropriate AC voltage signals to these electrodes, dielectrophoretic forces are generated to levitate cells suspended in the chamber and to affect their equilibrium heights. A laminar flow profile is established in the chamber so that fluid flows faster with increasing distance from the chamber walls. A cell carried in the flow stream will attain an equilibrium height, and a corresponding velocity, based on the balance of dielectrophoretic, gravitational, and hydrodynamic lift forces it experiences. We describe a theoretical model for this system and show that the cell velocity is a function of the mean fluid velocity, the voltage and frequency of the signals applied to the electrodes, and, most significantly, the cell dielectric properties. The validity of the model is demonstrated with human leukemia (HL-60) cells subjected to a parallel electrode array, and application of the device to separating HL-60 cells from peripheral blood mononuclear cells is shown.
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Cites
Field-Flow Fractionation: Analysis of Macromolecular, Colloidal, and Particulate Materials
Giddings, J. C. (1993) · Science · doi:10.1126/science.8502990 · Cited by 1,141
Separation of human breast cancer cells from blood by differential dielectric affinity.
Becker, F. F., Wang, X. B., Huang, Y., Pethig, R., Vykoukal, J., & Gascoyne, P. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.860 · Cited by 680
Self-citationSeparation of Blood Leucocytes, Granulocytes and Lymphocytes
Bøyum, A. (1974) · Tissue Antigens · doi:10.1111/j.1399-0039.1974.tb00252.x · Cited by 663
Linear and nonlinear electrode polarization and biological materials
Schwan, H. P. (1992) · Annals of Biomedical Engineering · doi:10.1007/bf02368531 · Cited by 233
Wang, X.-B., Huang, Y., Gascoyne, P. R. C., Becker, F. F., Hölzel, R., & Pethig, R. (1994) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(94)90170-8 · Cited by 193
Self-citationDielectrophoretic manipulation of cells with spiral electrodes
Wang, X. B., Huang, Y., Wang, X., Becker, F. F., & Gascoyne, P. R. C. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78834-9 · Cited by 121
Self-citationDifferentiation of viable and non-viable bacterial biofilms using electrorotation
Zhou, X., Markx, G. H., Pethig, R., & Eastwood, I. M. (1995) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(95)00072-j · Cited by 68
Field-flow fractionation of macromolecules
Giddings, J. C. (1989) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)83561-5 · Cited by 32
THE USE OF MONOCLONAL ANTIBODIES IN ALLOGENEIC BONE MARROW TRANSPLANTATION
Fischer, A. (1993) · British Journal of Haematology · doi:10.1111/j.1365-2141.1993.tb04686.x · Cited by 12
Cited by
ELECTRICAL FORCES FOR MICROSCALE CELL MANIPULATION
Voldman, J. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095739 · Cited by 892
Gupta, V., Jafferji, I., Garza, M., Melnikova, V. O., Hasegawa, D. K., Pethig, R., & Davis, D. W. (2012) · Biomicrofluidics · doi:10.1063/1.4731647 · Cited by 383
Yang, J., Huang, Y., Wang, X.-B., Becker, F. F., & Gascoyne, P. R. C. (1999) · Analytical Chemistry · doi:10.1021/ac981250p · Cited by 310
Self-citationMicrofluidic approaches for cancer cell detection, characterization, and separation
Chen, J., Li, J., & Sun, Y. (2012) · Lab on a Chip · doi:10.1039/c2lc21273k · Cited by 301
Isolation of Circulating Tumor Cells by Dielectrophoresis
Gascoyne, P., & Shim, S. (2014) · Cancers · doi:10.3390/cancers6010545 · Cited by 275
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Metadata
- Authors
- Huang, Y., Wang, X. B., Becker, F. F., & Gascoyne, P. R.
- Venue
- Biophysical Journal
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 73
- Issue
- 2
- Pages
- 1118-1129
- ISSN
- 0006-3495 (ISSN-L)
- OpenAlex
- W2002338347
- Cited by
- 302
- References
- 9
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Huang, Y., Wang, X. B., Becker, F. F., & Gascoyne, P. R. (1997). Introducing dielectrophoresis as a new force field for field-flow fractionation. Biophysical Journal. https://doi.org/10.1016/s0006-3495(97)78144-x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
