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Cited by 105Stress Responses and CortisolNeuropeptides and Animal PhysiologyAdrenal Hormones and Disorders

Sensitivity to glucocorticoid-mediated fast-feedback regulation of the hypothalamic–pituitary–adrenal axis is dependent upon stressor specific neurocircuitry

Thrivikraman, K.V, Nemeroff, Charles B, Plotsky, Paul M·2000·Brain Research
DOI 10.1016/s0006-8993(00)02405-7
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Abstract

Unlabelled Fos-protein immunoreactivity (Fos-IR) was used to identify neurocircuits potentially participating in the regulation of hypothalamic-pituitary-adrenal (HPA) axis sensitivity to glucocorticoid-mediated fast-feedback in rats exposed to the physical stressor, hemorrhage, or the psychological stressor, airpuff startle. Marked regional brain differences in the Fos-IR expression were observed in response to these stressors. Specifically, after hemorrhage, nuclear Fos-IR increased in the nucleus of the solitary tract and other brainstem regions known to regulate hemodynamic processes including the supraoptic nucleus, and the magnocellular division of hypothalamic paraventricular nucleus (PVN). In contrast, after airpuff startle Fos-IR increased in the dorsomedial and lateral hypothalamus as well as in the lateral septum. Thus, activation of brainstem neurocircuits predominated after hemorrhage whereas activation of forebrain neurocircuits predominated after airpuff startle. In other regions, the magnitude of stressor-induced Fos-IR expression varied in a region-specific manner. When stressor exposure was preceded by administration of corticosterone to achieve levels within the physiological range after stressors, HPA axis responses were suppressed in response to the airpuff startle but not to either a small or moderate hemorrhage.In conclusion (1) fast-feedback mediated inhibition of HPA axis activity is critically dependent upon stressor modality; (2) this apparent selectivity is reflected by differences in the nature of the neurocircuitry mediating these stressors. It is suggested that determination of the central actions of glucocorticoids in mediating fast-feedback regulation of the HPA axis requires evaluation of the interactions between activated glucocorticoid receptors and intracellular signaling cascades evoked by convergent neuronal input.

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  • Individual stress-system components respond specifically to different challenges, and the physiological stress response profile changes subtly with different stressors.

    “At the same time, the individual components of the SRS respond in specific ways to different types of challenges (section 4), and the physiological profile of the stress response has been shown to change subtly with different types of stressors (e.g., Nair et al., 2007; Pacák and Palkovits, 2001; Thrivikraman et al., 2000).”

    From The Adaptive Calibration Model of stress responsivity (2011) · cites this paper as Thrivikraman et al., 2000

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Authors
Thrivikraman, K. V., Nemeroff, C. B., & Plotsky, P. M.
Affiliations
Emory University (US)
Corresponding author
Thrivikraman, K.V
ORCID
Nemeroff, Charles B
Venue
Brain Research
Publisher
Elsevier BV
Published
2000-07
Volume
870
Issue
1-2
Pages
87-101
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/s0006-8993(00)02405-7
OpenAlex
W2033574728
Cited by
105
References
135
Citations by year
2022: 3 · 2021: 3 · 2020: 1 · 2019: 4 · 2017: 3 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 1 · 2012: 2
FWCI
3.47
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (R01MH042088, MH42088, MH-OD51745)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-33093)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
hypothalamic-pituitary-adrenal axis, glucocorticoid negative feedback, Fos expression, stressor specificity, nucleus tractus solitarius, hypothalamus, lateral septum, corticosterone, glucocorticoid receptor, stress response
MeSH terms
Air Movements, Animals, Consciousness, Feedback, Glucocorticoids, Hemorrhage, Hypothalamo-Hypophyseal System, Male, Neural Pathways, Paraventricular Hypothalamic Nucleus, Pituitary-Adrenal System, Receptors, Glucocorticoid, Reflex, Startle, Stress, Psychological, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Hypovolemia, Rats

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