Remission of major depression under deep brain stimulation of the lateral habenula in a therapy-refractory patient

Deep Brain Stimulation for Treatment-Resistant Depression

Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059 · see citing works

Lateral habenula as a source of negative reward signals in dopamine neurons

Matsumoto, M., & Hikosaka, O. (2007) · Nature · doi:10.1038/nature05860 · Cited by 1,292 · see citing works

Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression

Lozano, A. M., Mayberg, H. S., Giacobbe, P., Hamani, C., Craddock, R. C., & Kennedy, S. H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.034 · Cited by 1,024 · see citing works

Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Treatment-Resistant Depression

Malone, D. A., Dougherty, D. D., Rezai, A. R., Carpenter, L. L., Friehs, G. M., Eskandar, E. N., Rauch, S. L., Rasmussen, S. A., Machado, A. G., Kubu, C. S., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.029 · Cited by 897 · see citing works

Biogenic Amines and Emotion

Schildkraut, J. J., & Kety, S. S. (1967) · Science · doi:10.1126/science.156.3771.21 · Cited by 875 · see citing works

Habenula: crossroad between the basal ganglia and the limbic system

Hikosaka, O., Sesack, S. R., Lecourtier, L., & Shepard, P. D. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3463-08.2008 · Cited by 432 · see citing works

Alleviation of learned helplessness in the dog.

Seligman, M. E. P., Maier, S. F., & Geer, J. H. (1968) · Journal of Abnormal Psychology · doi:10.1037/h0025831 · Cited by 291 · see citing works

Covariation of activity in habenula and dorsal raphe nuclei following tryptophan depletion

Morris, J. S., Smith, K. A., Cowen, P. J., Friston, K. J., & Dolan, R. J. (1999) · NeuroImage · doi:10.1006/nimg.1999.0455 · Cited by 288 · see citing works

Stress models of depression: forming genetically vulnerable strains

Henn, F. A., & Vollmayr, B. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.019 · Cited by 274 · see citing works

The relative metabolic demand of inhibition and excitation

Waldvogel, D., van Gelderen, P., Muellbacher, W., Ziemann, U., Immisch, I., & Hallett, M. (2000) · Nature · doi:10.1038/35023171 · Cited by 271 · see citing works

Deep brain stimulation of the lateral habenula in treatment resistant major depression

Sartorius, A., & Henn, F. A. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2007.03.021 · Cited by 251 · see citing works

Opposite metabolic changes in the habenula and ventral tegmental area of a genetic model of helpless behavior

Shumake, J., Edwards, E., & Gonzalez-Lima, F. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04048-9 · Cited by 232 · see citing works

Evidence for structural abnormalities of the human habenular complex in affective disorders but not in schizophrenia

Ranft, K., Dobrowolny, H., Krell, D., Bielau, H., Bogerts, B., & Bernstein, H.-G. (2010) · Psychological Medicine · doi:10.1017/s0033291709990821 · Cited by 183 · see citing works

The Lateral Habenula:No Longer Neglected

Geisler, S., & Trimble, M. (2008) · CNS Spectrums · doi:10.1017/s1092852900016710 · Cited by 149 · see citing works

The Effects of Tryptophan Depletion on Neural Responses to Emotional Words in Remitted Depression

Roiser, J. P., Levy, J., Fromm, S. J., Nugent, A. C., Talagala, S. L., Hasler, G., Henn, F. A., Sahakian, B. J., & Drevets, W. C. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.05.002 · Cited by 123 · see citing works

GABA and acute psychoses

Meldrum, B. S. (1982) · Psychological Medicine · doi:10.1017/s003329170004321x · Cited by 118 · see citing works

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

Chaudhury, D., Walsh, J. J., Friedman, A. K., Juarez, B., Ku, S. M., Koo, J. W., Ferguson, D., Tsai, H.-C., Pomeranz, L., Christoffel, D. J., et al. (2013) · Nature · doi:10.1038/nature11713 · Cited by 1,156 · see citing works

The neurobiology of anhedonia and other reward-related deficits

Der-Avakian, A., & Markou, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.005 · Cited by 1,130 · see citing works

The habenula: from stress evasion to value-based decision-making

Hikosaka, O. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2866 · Cited by 955 · see citing works

The chronic mild stress (CMS) model of depression: History, evaluation and usage

Willner, P. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.002 · Cited by 959 · see citing works

Probing and regulating dysfunctional circuits using deep brain stimulation

Lozano, A. M., & Lipsman, N. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.020 · Cited by 665 · see citing works

A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge

Warden, M. R., Selimbeyoglu, A., Mirzabekov, J. J., Lo, M., Thompson, K. R., Kim, S.-Y., Adhikari, A., Tye, K. M., Frank, L. M., & Deisseroth, K. (2012) · Nature · doi:10.1038/nature11617 · Cited by 645 · see citing works

Synaptic potentiation onto habenula neurons in the learned helplessness model of depression

Li, B., Piriz, J., Mirrione, M., Chung, C., Proulx, C. D., Schulz, D., Henn, F., & Malinow, R. (2011) · Nature · doi:10.1038/nature09742 · Cited by 634 · see citing works

Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression

Cui, Y., Yang, Y., Ni, Z., Dong, Y., Cai, G., Foncelle, A., Ma, S., Sang, K., Tang, S., Li, Y., et al. (2018) · Nature · doi:10.1038/nature25752 · Cited by 597 · see citing works

A Randomized Sham-Controlled Trial of Deep Brain Stimulation of the Ventral Capsule/Ventral Striatum for Chronic Treatment-Resistant Depression

Dougherty, D. D., Rezai, A. R., Carpenter, L. L., Howland, R. H., Bhati, M. T., O’Reardon, J. P., Eskandar, E. N., Baltuch, G. H., Machado, A. D., Kondziolka, D., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.023 · Cited by 558 · see citing works

The subcallosal cingulate gyrus in the context of major depression

Hamani, C., Mayberg, H., Stone, S., Laxton, A., Haber, S., & Lozano, A. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.034 · Cited by 508 · see citing works

The neurobiology of depression and antidepressant action

Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works

Reward processing by the lateral habenula in normal and depressive behaviors

Proulx, C. D., Hikosaka, O., & Malinow, R. (2014) · Nature Neuroscience · doi:10.1038/nn.3779 · Cited by 461 · see citing works

βCaMKII in Lateral Habenula Mediates Core Symptoms of Depression

Li, K., Zhou, T., Liao, L., Yang, Z., Wong, C., Henn, F., Malinow, R., Yates, J. R., & Hu, H. (2013) · Science · doi:10.1126/science.1240729 · Cited by 411 · see citing works

Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action

Cao, J.-L., Covington, H. E., Friedman, A. K., Wilkinson, M. B., Walsh, J. J., Cooper, D. C., Nestler, E. J., & Han, M.-H. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3177-10.2010 · Cited by 402 · see citing works

Dysfunctional reward processing in depression

Admon, R., & Pizzagalli, D. A. (2015) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2014.12.011 · Cited by 343 · see citing works

GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment

Shabel, S. J., Proulx, C. D., Piriz, J., & Malinow, R. (2014) · Science · doi:10.1126/science.1250469 · Cited by 369 · see citing works

The place of dopamine in the cortico-basal ganglia circuit

Haber, S. N. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.10.008 · Cited by 364 · see citing works

Coil design considerations for deep transcranial magnetic stimulation

Deng, Z.-D., Lisanby, S. H., & Peterchev, A. V. (2014) · Clinical Neurophysiology · doi:10.1016/j.clinph.2013.11.038 · Cited by 308 · see citing works

Lateral habenula in the pathophysiology of depression

Yang, Y., Wang, H., Hu, J., & Hu, H. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.10.024 · Cited by 254 · see citing works

Circuit Mechanisms of Reward, Anhedonia, and Depression

Höflich, A., Michenthaler, P., Kasper, S., & Lanzenberger, R. (2019) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy081 · Cited by 253 · see citing works

Chronic Stress Induces Activity, Synaptic, and Transcriptional Remodeling of the Lateral Habenula Associated with Deficits in Motivated Behaviors

Cerniauskas, I., Winterer, J., de Jong, J. W., Lukacsovich, D., Yang, H., Khan, F., Peck, J. R., Obayashi, S. K., Lilascharoen, V., Lim, B. K., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.005 · Cited by 187 · see citing works

Deep brain stimulation for treatment-resistant depression: systematic review of clinical outcomes

Morishita, T., Fayad, S. M., Higuchi, M.-A., Nestor, K. A., & Foote, K. D. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0282-1 · Cited by 216 · see citing works

PERIL AND PLEASURE: AN RDOC-INSPIRED EXAMINATION OF THREAT RESPONSES AND REWARD PROCESSING IN ANXIETY AND DEPRESSION: Neighborhood Characteristics and Mental Health

Dillon, D. G., Rosso, I. M., Pechtel, P., Killgore, W. D. S., Rauch, S. L., & Pizzagalli, D. A. (2014) · Depression and Anxiety · doi:10.1002/da.22202 · Cited by 209 · see citing works

Optogenetic dissection of medial prefrontal cortex circuitry

Riga, D., Matos, M. R., Glas, A., Smit, A. B., Spijker, S., & Van den Oever, M. C. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00230 · Cited by 208 · see citing works

The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview

Lecca, S., Meye, F. J., & Mameli, M. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12480 · Cited by 196 · see citing works

Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus

Vadnie, C. A., & McClung, C. A. (2017) · Neural Plasticity · doi:10.1155/2017/1504507 · Cited by 199 · see citing works

Deep brain stimulation for depression.

Figee, M., Riva-Posse, P., Choi, K. S., Bederson, L., Mayberg, H. S., & Kopell, B. H. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01270-3 · Cited by 175 · see citing works

Translating the habenula-from rodents to humans

Boulos, L.-J., Darcq, E., & Kieffer, B. L. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.003 · Cited by 164 · see citing works

Opioid system is necessary but not sufficient for antidepressive actions of ketamine in rodents

Klein, M. E., Chandra, J., Sheriff, S., & Malinow, R. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916570117 · Cited by 156 · see citing works

Deep Brain Stimulation of the Human Reward System for Major Depression—Rationale, Outcomes and Outlook

Schlaepfer, T. E., Bewernick, B. H., Kayser, S., Hurlemann, R., & Coenen, V. A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.28 · Cited by 160 · see citing works

The role of the habenula in drug addiction

Velasquez, K. M., Molfese, D. L., & Salas, R. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00174 · Cited by 155 · see citing works

Learned helplessness: unique features and translational value of a cognitive depression model

Vollmayr, B., & Gass, P. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1654-2 · Cited by 155 · see citing works

Hypothalamus-habenula potentiation encodes chronic stress experience and drives depression onset

Zheng, Z., Guo, C., Li, M., Yang, L., Liu, P., Zhang, X., Liu, Y., Guo, X., Cao, S., Dong, Y., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.01.011 · Cited by 142 · see citing works

Pharmacological inhibition of the lateral habenula improves depressive-like behavior in an animal model of treatment resistant depression

Winter, C., Vollmayr, B., Djodari-Irani, A., Klein, J., & Sartorius, A. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.07.034 · Cited by 145 · see citing works

Prediction of SSRI treatment response in major depression based on serotonin transporter interplay between median raphe nucleus and projection areas

Lanzenberger, R., Kranz, G. S., Haeusler, D., Akimova, E., Savli, M., Hahn, A., Mitterhauser, M., Spindelegger, C., Philippe, C., Fink, M., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.07.023 · Cited by 139 · see citing works

Glial Dysfunction in the Mouse Habenula Causes Depressive-Like Behaviors and Sleep Disturbance

Cui, W., Mizukami, H., Yanagisawa, M., Aida, T., Nomura, M., Isomura, Y., Takayanagi, R., Ozawa, K., Tanaka, K., & Aizawa, H. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1465-14.2014 · Cited by 139 · see citing works

Topography of descending projections from anterior insular and medial prefrontal regions to the lateral habenula of the epithalamus in the rat

Kim, U., & Lee, T. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08030.x · Cited by 133 · see citing works

A neural pathway controlling motivation to exert effort

Proulx, C. D., Aronson, S., Milivojevic, D., Molina, C., Loi, A., Monk, B., Shabel, S. J., & Malinow, R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1801837115 · Cited by 119 · see citing works

High field FMRI reveals thalamocortical integration of segregated cognitive and emotional processing in mediodorsal and intralaminar thalamic nuclei

Metzger, C. D. (2010) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2010.00138 · Cited by 114 · see citing works

Electrical stimulation alleviates depressive-like behaviors of rats: investigation of brain targets and potential mechanisms

Lim, L. W., Prickaerts, J., Huguet, G., Kadar, E., Hartung, H., Sharp, T., & Temel, Y. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.24 · Cited by 116 · see citing works

Dosing of electrical parameters in Deep Brain Stimulation (DBS) for intractable depression: a review of clinical studies

Ramasubbu, R., Lang, S., & Kiss, Z. H. T. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00302 · Cited by 111 · see citing works

Anhedonia in depression symptomatology: appetite dysregulation and defective brain reward processing

Coccurello, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112041 · Cited by 106 · see citing works

Does the kappa opioid receptor system contribute to pain aversion?

Cahill, C. M., Taylor, A. M. W., Cook, C., Ong, E., Morón, J. A., & Evans, C. J. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00253 · Cited by 105 · see citing works

Synaptic Mechanisms Regulating Mood State Transitions in Depression

Parekh, P. K., Johnson, S. B., & Liston, C. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110920-040422 · Cited by 101 · see citing works

A systematic review and meta-analysis of deep brain stimulation in treatment-resistant depression

Zhou, C., Zhang, H., Qin, Y., Tian, T., Xu, B., Chen, J., Zhou, X., Zeng, L., Fang, L., Qi, X., et al. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.11.012 · Cited by 100 · see citing works

Somatic therapies for treatment-resistant depression: ECT, TMS, VNS, DBS

Cusin, C., & Dougherty, D. D. (2012) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-2-14 · Cited by 98 · see citing works

Progress in understanding mood disorders: optogenetic dissection of neural circuits

Lammel, S., Tye, K. M., & Warden, M. R. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12049 · Cited by 98 · see citing works

Involvement of Infralimbic Prefrontal Cortex but not Lateral Habenula in Dopamine Attenuation After Chronic Mild Stress

Moreines, J. L., Owrutsky, Z. L., & Grace, A. A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.249 · Cited by 93 · see citing works

Deep transcranial magnetic stimulation (dTMS)—Beyond depression

Tendler, A., Barnea Ygael, N., Roth, Y., & Zangen, A. (2016) · Expert Review of Medical Devices · doi:10.1080/17434440.2016.1233812 · Cited by 93 · see citing works

A glutamatergic projection from the lateral hypothalamus targets VTA-projecting neurons in the lateral habenula of the rat

Poller, W. C., Madai, V. I., Bernard, R., Laube, G., & Veh, R. W. (2013) · Brain Research · doi:10.1016/j.brainres.2013.01.029 · Cited by 77 · see citing works

Limbic versus cognitive target for deep brain stimulation in treatment-resistant depression: accumbens more promising than caudate

Millet, B., Jaafari, N., Polosan, M., Baup, N., Giordana, B., Haegelen, C., Chabardes, S., Fontaine, D., Devaux, B., Yelnik, J., et al. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.05.006 · Cited by 77 · see citing works

Deep brain stimulation in the bed nucleus of the stria terminalis and medial forebrain bundle in a patient with major depressive disorder and anorexia nervosa

Blomstedt, P., Naesström, M., & Bodlund, O. (2017) · Clinical Case Reports · doi:10.1002/ccr3.856 · Cited by 77 · see citing works

Impaired reward-related learning signals in remitted unmedicated patients with recurrent depression

Geugies, H., Mocking, R. J. T., Figueroa, C. A., Groot, P. F. C., Marsman, J.-B. C., Servaas, M. N., Steele, J. D., Schene, A. H., & Ruhé, H. G. (2019) · Brain · doi:10.1093/brain/awz167 · Cited by 67 · see citing works

Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula

Wang, M., Li, P., Li, Z., da Silva, B. S., Zheng, W., Xiang, Z., He, Y., Xu, T., Cordeiro, C., Deng, L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37601-x · Cited by 73 · see citing works

A new translational target for deep brain stimulation to treat depression

Kiening, K., & Sartorius, A. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201302947 · Cited by 70 · see citing works

Untitled work

Cook (2014) · doi:10.1016/j.nec.2013.10.002 · Cited by 69 · see citing works

Bilateral Habenula deep brain stimulation for treatment-resistant depression: clinical findings and electrophysiological features

Zhang, C., Zhang, Y., Luo, H., Xu, X., Yuan, T.-F., Li, D., Cai, Y.-Y., Gong, H., Peng, D.-H., Fang, Y.-R., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01818-z · Cited by 63 · see citing works

The antidepressant effect of light therapy from retinal projections.

Li, X., & Li, X. (2018) · Neuroscience Bulletin · doi:10.1007/s12264-018-0210-1 · Cited by 47 · see citing works

Neurostimulation therapies for treatment resistant depression: A focus on vagus nerve stimulation and deep brain stimulation

Rizvi, S. J., Donovan, M., Giacobbe, P., Placenza, F., Rotzinger, S., & Kennedy, S. H. (2011) · International Review of Psychiatry · doi:10.3109/09540261.2011.630993 · Cited by 42 · see citing works

Emerging, reemerging, and forgotten brain areas of the reward circuit: Notes from the 2010 Motivational Neural Networks conference

McGinty, V. B., Hayden, B. Y., Heilbronner, S. R., Dumont, E. C., Graves, S. M., Mirrione, M. M., du Hoffmann, J., Sartor, G. C., España, R. A., Millan, E. Z., et al. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.036 · Cited by 36 · see citing works

Functionally altered neurocircuits in a rat model of treatment-resistant depression show prominent role of the habenula

Gass, N., Cleppien, D., Zheng, L., Schwarz, A. J., Meyer-Lindenberg, A., Vollmayr, B., Weber-Fahr, W., & Sartorius, A. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.12.004 · Cited by 36 · see citing works

Awakening Neuropsychiatric Research Into the Stria Medullaris: Development of a Diffusion-Weighted Imaging Tractography Protocol of This Key Limbic Structure

Roddy, D. W., Roman, E., Rooney, S., Andrews, S., Farrell, C., Doolin, K., Levins, K. J., Tozzi, L., Tierney, P., Barry, D., et al. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00039 · Cited by 16 · see citing works

The medial habenula: still neglected

Viswanath, H., Carter, A. Q., Baldwin, P. R., Molfese, D. L., & Salas, R. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00931 · Cited by 133 · see citing works

[The roles of habenula and related neural circuits in neuropsychiatric diseases].

Wu, Y., Zhang, S., & Chen, Z. (2019) · PubMed Central · doi:10.3785/j.issn.1008-9292.2019.06.12

The molecular mechanisms controlling morphogenesis and wiring of the habenula

Schmidt, E. R. E., & Pasterkamp, R. J. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.08.008 · Cited by 22 · see citing works

Treating electroconvulsive therapy–induced mania with more electroconvulsive therapy: Evidence for electroconvulsive therapy as the ultra-mood stabilizer

Thomas, R. K., White, P. J., & Dursun, S. M. (2018) · SAGE Open Medical Case Reports · doi:10.1177/2050313x18799236 · Cited by 9 · see citing works

[Clinical analysis of safety and effectiveness of electroconvulsive therapy].

Dabrowski, M., & Parnowski, T. (2012) · PubMed · Cited by 5 · see citing works