Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type
Abstract
Cyclic AMP (cAMP) is disrupted in the brain in dementia of the Alzheimer type (DAT). We investigated whether the cAMP reduction is accompanied by an alteration in the cAMP response element binding protein (CREB) downstream in DAT and control hippocampi. Immunoreactivity of pCREB was significantly decreased in DAT, while total CREB level was unchanged. These findings indicate that impaired cAMP signaling may contribute to the pathophysiology of the disease.
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In human AD brains, pCREB immunoreactivity is significantly decreased.
“In human AD brains, pCREB immunoreactivity was significantly decreased (70).”
Reduced level of phosphorylated CREB has been reported in Alzheimer's disease patients and experimental models of Alzheimer's disease.
“Reduced level of phosphorylated CREB has been reported in AD patients and experimental models of AD [60].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [60]
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- Authors
- Yamamoto-Sasaki, M., Ozawa, H., Saito, T., Rösler, M., & Riederer, P.
- Affiliations
- University of Würzburg (DE)
- Sapporo Medical University (JP)
- Corresponding author
- Yamamoto-Sasaki, Megumi
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1999-04
- Volume
- 824
- Issue
- 2
- Pages
- 300-303
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1992476409
- Cited by
- 198
- References
- 14
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 11 · 2019: 7 · 2018: 9 · 2017: 9 · 2016: 10 · 2015: 12 · 2014: 11 · 2013: 12 · 2012: 10
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Forschung und Technologie
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Alzheimer's disease, cyclic AMP response element binding protein, CREB phosphorylation, hippocampus, cAMP signaling, dementia, protein phosphorylation, neurodegeneration
- MeSH terms
- Adult, Aged, Alzheimer Disease, Female, Hippocampus, Humans, Male, Middle Aged, Nerve Tissue Proteins, Phosphorylation, Linear Models, Cyclic AMP Response Element-Binding Protein
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