Cited by 198Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroscience and Neuropharmacology Research

Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type

Yamamoto-Sasaki, Megumi, Ozawa, Hiroki, Saito, Toshikazu, Michael Rösler, Riederer, Peter·1999·Brain Research

Abstract

Cyclic AMP (cAMP) is disrupted in the brain in dementia of the Alzheimer type (DAT). We investigated whether the cAMP reduction is accompanied by an alteration in the cAMP response element binding protein (CREB) downstream in DAT and control hippocampi. Immunoreactivity of pCREB was significantly decreased in DAT, while total CREB level was unchanged. These findings indicate that impaired cAMP signaling may contribute to the pathophysiology of the disease.

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Crossref · 10.1016/s0006-8993(99)01220-2

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14 of 14 references verified0 citation errors · 0 not checkable

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Authors
Yamamoto-Sasaki, M., Ozawa, H., Saito, T., Rösler, M., & Riederer, P.
Affiliations
  • University of Würzburg (DE)
  • Sapporo Medical University (JP)
Corresponding author
Yamamoto-Sasaki, Megumi
Venue
Brain Research
Publisher
Elsevier BV
Published
1999-04
Volume
824
Issue
2
Pages
300-303
ISSN
0006-8993 (ISSN-L)
OpenAlex
W1992476409
Cited by
198
References
14
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 11 · 2019: 7 · 2018: 9 · 2017: 9 · 2016: 10 · 2015: 12 · 2014: 11 · 2013: 12 · 2012: 10
FWCI
3.19
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Bundesministerium für Forschung und Technologie
  • Ministry of Education, Culture, Sports, Science and Technology
  • Ministry of Health, Labour and Welfare
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
Alzheimer's disease, cyclic AMP response element binding protein, CREB phosphorylation, hippocampus, cAMP signaling, dementia, protein phosphorylation, neurodegeneration
MeSH terms
Adult, Aged, Alzheimer Disease, Female, Hippocampus, Humans, Male, Middle Aged, Nerve Tissue Proteins, Phosphorylation, Linear Models, Cyclic AMP Response Element-Binding Protein

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