Cited by 227Bone Metabolism and DiseasesProtease and Inhibitor MechanismsBone and Dental Protein Studies

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Proteinases in bone resorption: obvious and less obvious roles

Delaissé, Jean-Marie, Engsig, Michael T, Everts, Vincent, del Carmen Ovejero, Maria, Ferreras, Mercedes, Lund, Leif, Vu, Thiennu H, Werb, Zena, Winding, Bent, Lochter, André, Karsdal, Morten A, Troen, Tine, Kirkegaard, Tove, Lenhard, Thomas, Heegaard, Anne-Marie, Neff, Lynn, Baron, Roland, Foged, Niels T·2000·Clinica Chimica Acta

DOI 10.1016/s0009-8981(99)00230-2

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Abstract

Bone resorption is critical for the development and the maintenance of the skeleton, and improper regulation of bone resorption leads to pathological situations. Proteinases are necessary for this process. In this review, we show that this need of proteinases is not only because they are required for the solubilization of bone matrix, but also because they are key components of the mechanism that determines where and when bone resorption will be initiated. Moreover, there are indications that proteinases may also determine whether resorption will be followed by bone formation. Some of the proteinases involved in these different steps of the resorption processes were recently identified, as for instance cathepsin K, MMP-9 (gelatinase B), and interstitial collagenase. However, there is also increasing evidence showing that the critical proteinase(s) may vary depending on the bone type or on other factors.

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Authors: Delaissé, J.-M., Engsig, M. T., Everts, V., del Carmen Ovejero, M., Ferreras, M., Lund, L., Vu, T. H., Werb, Z., Winding, B., Lochter, A., Karsdal, M. A., Troen, T., Kirkegaard, T., Lenhard, T., Heegaard, A.-M., Neff, L., Baron, R., & Foged, N. T.
Affiliations: Center for Clinical & Basic Research (DK)
Academic Center for Dentistry Amsterdam (NL)
University of Copenhagen (DK)
University of California, San Francisco (US)
Yale University (US)
Corresponding author: Delaissé, Jean-Marie
ORCID: Delaissé, Jean-Marie
Everts, Vincent
Werb, Zena
Karsdal, Morten A
Kirkegaard, Tove
Heegaard, Anne-Marie
Baron, Roland
Foged, Niels T
Venue: Clinica Chimica Acta
Publisher: Elsevier BV
Published: 2000-02
Volume: 291
Issue: 2
Pages: 223-234
ISSN: 0009-8981 (ISSN-L)
DOI: 10.1016/s0009-8981(99)00230-2
OpenAlex: W2100282191
Cited by: 227
References: 89
Citations by year: 2026: 2 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 9 · 2018: 10 · 2017: 5 · 2016: 5 · 2015: 11 · 2014: 8 · 2013: 9 · 2012: 11
FWCI: 2.90
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinica Chimica Acta (publishedVersion)
PubMed (publishedVersion)
UvA-DARE (University of Amsterdam) (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
VU Research Portal (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
Keywords: bone resorption, proteolytic enzymes, cathepsin K, MMP-9, MMP-1, bone formation, bone remodeling
MeSH terms: Bone Diseases, Bone Resorption, Extracellular Matrix, Humans, Endopeptidases

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Proteinases in bone resorption: obvious and less obvious roles

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