The DOI matches its Crossref record; 86 of the 89 references it cites were found in a registry or an index.
Proteinases in bone resorption: obvious and less obvious roles
Abstract
Bone resorption is critical for the development and the maintenance of the skeleton, and improper regulation of bone resorption leads to pathological situations. Proteinases are necessary for this process. In this review, we show that this need of proteinases is not only because they are required for the solubilization of bone matrix, but also because they are key components of the mechanism that determines where and when bone resorption will be initiated. Moreover, there are indications that proteinases may also determine whether resorption will be followed by bone formation. Some of the proteinases involved in these different steps of the resorption processes were recently identified, as for instance cathepsin K, MMP-9 (gelatinase B), and interstitial collagenase. However, there is also increasing evidence showing that the critical proteinase(s) may vary depending on the bone type or on other factors.
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“The ruffled border membrane allows large vesicle transport, the delivery of hydrochloric acid (by vacuolar-type H + ATPase186) and chloride ion channel-7 (CLC-7),187 and the release of several lysosomal proteases, such as cathepsin K, TRAP, and MMPs.188”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [188]
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The matrix corroded: podosomes and invadopodia in extracellular matrix degradation
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Self-citationBone remodeling: an operational process ensuring survival and bone mechanical competence
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Metadata
- Authors
- Delaissé, J.-M., Engsig, M. T., Everts, V., del Carmen Ovejero, M., Ferreras, M., Lund, L., Vu, T. H., Werb, Z., Winding, B., Lochter, A., Karsdal, M. A., Troen, T., Kirkegaard, T., Lenhard, T., Heegaard, A.-M., Neff, L., Baron, R., & Foged, N. T.
- Affiliations
- Center for Clinical & Basic Research (DK)
- Academic Center for Dentistry Amsterdam (NL)
- University of Copenhagen (DK)
- University of California, San Francisco (US)
- Yale University (US)
- Corresponding author
- Delaissé, Jean-Marie
- ORCID
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 291
- Issue
- 2
- Pages
- 223-234
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W2100282191
- Cited by
- 227
- References
- 89
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 9 · 2018: 10 · 2017: 5 · 2016: 5 · 2015: 11 · 2014: 8 · 2013: 9 · 2012: 11
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- VU Research Portal (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- bone resorption, proteolytic enzymes, cathepsin K, MMP-9, MMP-1, bone formation, bone remodeling
- MeSH terms
- Bone Diseases, Bone Resorption, Extracellular Matrix, Humans, Endopeptidases
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