Nicotinic receptors modulating somatodendritic and terminal dopamine release differ pharmacologically

Reuben, Melanie; Boye, Sandra; Clarke, Paul B.S

doi:10.1016/s0014-2999(00)00004-2

Cited by 33Nicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology ResearchSmoking Behavior and Cessation

Nicotinic receptors modulating somatodendritic and terminal dopamine release differ pharmacologically

Reuben, Melanie, Boye, Sandra, Clarke, Paul B.S·2000·European Journal of Pharmacology

DOI 10.1016/s0014-2999(00)00004-2

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Abstract

Ascending dopaminergic and noradrenergic neurons possess somatodendritic and terminal nicotinic cholinoceptors in the rat. Each neuronal population expresses mRNA for several types of nicotinic cholinoceptor subunit, including alpha6 and beta3. In superfused rat striatal synaptosomes, epibatidine evoked release of [3H]dopamine with similar efficacy to ACh, whereas nicotine and cytisine were weaker (70+/-6% and 58+/-6%, respectively). The four agonists were equi-efficacious in evoking [3H]noradrenaline release from hippocampal synaptosomes. Nicotine-evoked synaptosomal release was tetrodotoxin-insensitive. Somatodendritic nicotinic cholinoceptors on dopaminergic neurons were studied using a dendrosomal [3H]dopamine release assay and also in locomotor activity tests. In both assays, nicotine appeared more efficacious than epibatidine. Furthermore, with repeated nicotine exposure, the acute locomotor stimulant response to nicotine increased, whereas the epibatidine response became undetectable. In conclusion, somatodendritic nicotinic cholinoceptors located on dopaminergic neurons appear to differ pharmacologically from those on striatal dopaminergic terminals and hippocampal noradrenergic terminals.

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Authors: Reuben, M., Boye, S., & Clarke, P. B. S.
Affiliations: McGill University (CA)
Corresponding author: Clarke, Paul B.S
ORCID: Clarke, Paul B.S
Venue: European Journal of Pharmacology
Publisher: Elsevier BV
Published: 2000-03
Volume: 393
Issue: 1-3
Pages: 39-49
ISSN: 0014-2999 (ISSN-L)
DOI: 10.1016/s0014-2999(00)00004-2
OpenAlex: W2041566830
Cited by: 33
References: 59
Citations by year: 2022: 1 · 2021: 1 · 2020: 1
FWCI: 1.45
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Pharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Stiftung VERUM
H. Lundbeck A/S
Fonds de Recherche du Québec - Santé
Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords: nicotinic acetylcholine receptors, dopaminergic terminals, noradrenergic terminals, dopamine release, noradrenaline release, epibatidine, nicotine, cytisine, locomotor activity, synaptosomes, striatum, hippocampus, receptor pharmacology
MeSH terms: Animals, Corpus Striatum, Dopamine, Hippocampus, Male, Mecamylamine, Motor Activity, Neurons, Nicotine, Norepinephrine, Pyridines, Receptors, Nicotinic, Recombinant Proteins, Synaptosomes, Tetrodotoxin, Tritium, Rats, Sprague-Dawley, Nicotinic Agonists, Nicotinic Antagonists, Bridged Bicyclo Compounds, Heterocyclic, Rats

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Nicotinic receptors modulating somatodendritic and terminal dopamine release differ pharmacologically

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